STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
uvrYPutative 2-component transcriptional regulator; Member of the two-component regulatory system UvrY/BarA involved in the regulation of carbon metabolism via the CsrA/CsrB regulatory system. UvrY activates the transcription of the untranslated csrB RNA and of barA, in an autoregulatory loop. Mediates the effects of CsrA on csrB RNA by BarA-dependent and BarA-independent mechanisms (By similarity). (218 aa)    
Predicted Functional Partners:
barA
Sensor-regulator; Member of the two-component regulatory system UvrY/BarA involved in the regulation of carbon metabolism via the CsrA/CsrB regulatory system. Phosphorylates UvrY, probably via a four-step phosphorelay (By similarity).
 
 0.999
sdiA
Transcriptional regulator of ftsQAZ gene cluster; Code: K; COG: COG2771.
   
 0.919
evgS
Putative sensor for regulator EvgA.
  
 
 0.851
arcB
Histidine protein kinase/phosphatase, aerobic respiration sensor-response protein, sensor for arcA; Member of the two-component regulatory system ArcB/ArcA. Sensor-regulator protein for anaerobic repression of the arc modulon. Activates ArcA via a four-step phosphorelay. ArcB can also dephosphorylate ArcA by a reverse phosphorelay involving His-717 and Asp-576 (By similarity).
 
 
 
 0.788
csrA
Carbon storage regulator; A key translational regulator that binds mRNA to regulate translation initiation and/or mRNA stability. Mediates global changes in gene expression, shifting from rapid growth to stress survival by linking envelope stress, the stringent response and the catabolite repression systems. Usually binds in the 5'-UTR; binding at or near the Shine-Dalgarno sequence prevents ribosome-binding, repressing translation, binding elsewhere in the 5'-UTR can activate translation and/or stabilize the mRNA. Its function is antagonized by small RNA(s).
  
   
 0.768
SF0995
Two-component system, OmpR family, sensor histidine kinase TorS; Code: T; COG: COG0642.
 
 
 
 0.727
uvrC
Excinuclease ABC, subunit C; Code: L; COG: COG0322.
  
  
 0.648
uhpB
Sensor histidine protein kinase, phosphorylates UhpA; Code: T; COG: COG0642.
 
   0.636
yhjB
LuxR family transcriptional regulator; Similar to Shigella flexneri conserved hypothetical protein ref: NP_085397.1 (448 aa). BLAST with identity of 77% in 448 aa. This CDS contains an in-frame stop codon. The sequence has been checked and is believed to be correct.
  
     0.624
csgD
Probable csgAB operon transcriptional regulatory protein; Code: K; COG: COG2771.
  
     0.616
Your Current Organism:
Shigella flexneri
NCBI taxonomy Id: 198214
Other names: S. flexneri 2a str. 301, Shigella flexneri 2a str. 301, Shigella flexneri serotype 2a str. 301
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