STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
nrdARibonucleoside diphosphate reductase 1, alpha subunit, B1; Code: F; COG: COG0209. (761 aa)    
Predicted Functional Partners:
nrdB
Ribonucleoside-diphosphate reductase 1, beta subunit, B2; Code: F; COG: COG0208.
 
 0.999
nrdF
Ribonucleoside-diphosphate reductase 2, beta chain; Code: F; COG: COG0208.
  
 0.987
yqgE
Conserved hypothetical protein; Code: K; COG: COG1678; Belongs to the UPF0301 (AlgH) family.
  
 0.944
tmk
Thymidylate kinase; Catalyzes the reversible phosphorylation of deoxythymidine monophosphate (dTMP) to deoxythymidine diphosphate (dTDP), using ATP as its preferred phosphoryl donor. Situated at the junction of both de novo and salvage pathways of deoxythymidine triphosphate (dTTP) synthesis, is essential for DNA synthesis and cellular growth (By similarity).
  
 
 0.920
adk
Adenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family.
     
 0.916
ndk
Nucleoside diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family.
     
 0.916
cmk
Cytidylate kinase; Code: F; COG: COG0283.
  
 
 0.915
gmk
Guanylate kinase; Essential for recycling GMP and indirectly, cGMP.
     
 0.910
pykF
Pyruvate kinase I; Code: G; COG: COG0469; Belongs to the pyruvate kinase family.
     
 0.903
pykA
Pyruvate kinase II; Code: G; COG: COG0469; Belongs to the pyruvate kinase family.
     
 0.903
Your Current Organism:
Shigella flexneri
NCBI taxonomy Id: 198214
Other names: S. flexneri 2a str. 301, Shigella flexneri 2a str. 301, Shigella flexneri serotype 2a str. 301
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