STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
oxcPutative enzyme; Code: EH; COG: COG0028; Belongs to the TPP enzyme family. (564 aa)    
Predicted Functional Partners:
frc
Putative enzyme; Involved in the catabolism of oxalate and in the adapatation to low pH via the induction of the oxalate-dependent acid tolerance response (ATR). Catalyzes the transfer of the CoA moiety from formyl- CoA to oxalate (By similarity); Belongs to the CoA-transferase III family. Frc subfamily.
 
  
 0.992
yfdV
Putative receptor protein; Code: R; COG: COG0679.
 
  
 0.937
yfdX
Conserved hypothetical protein.
   
  
 0.904
ydeP
Putative oxidoreductase, major subunit; Probably involved in acid resistance; Belongs to the prokaryotic molybdopterin-containing oxidoreductase family.
   
  
 0.830
ilvH
Acetolactate synthase III, small subunit; Code: E; COG: COG0440.
 
 
 0.821
ilvN
Acetolactate synthase I, valine sensitive, small subunit; Code: E; COG: COG0440.
  
 
 0.747
arcC
Putative carbamate kinase; Code: E; COG: COG0549.
      
 0.732
yfdE
Putative enzyme; Code: C; COG: COG1804.
 
  
 0.713
ilvC
Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate.
 
  
 0.599
ydeO
Putative ARAC-type regulatory protein; Induces the expression of gadE. Could also regulate the expression of other genes involved in acid resistance (By similarity).
   
  
 0.579
Your Current Organism:
Shigella flexneri
NCBI taxonomy Id: 198214
Other names: S. flexneri 2a str. 301, Shigella flexneri 2a str. 301, Shigella flexneri serotype 2a str. 301
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