node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
apt | guaA | SAMN02745193_02531 | SAMN02745193_01922 | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | GMP synthase (glutamine-hydrolyzing); Catalyzes the synthesis of GMP from XMP. | 0.988 |
apt | guaB | SAMN02745193_02531 | SAMN02745193_01817 | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | 0.856 |
apt | pyrG | SAMN02745193_02531 | SAMN02745193_01045 | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | CTP synthase; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates. | 0.515 |
argS | guaA | SAMN02745193_01504 | SAMN02745193_01922 | arginyl-tRNA synthetase. | GMP synthase (glutamine-hydrolyzing); Catalyzes the synthesis of GMP from XMP. | 0.958 |
argS | guaB | SAMN02745193_01504 | SAMN02745193_01817 | arginyl-tRNA synthetase. | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | 0.417 |
argS | pyrG | SAMN02745193_01504 | SAMN02745193_01045 | arginyl-tRNA synthetase. | CTP synthase; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates. | 0.852 |
argS | rplA | SAMN02745193_01504 | SAMN02745193_02292 | arginyl-tRNA synthetase. | Large subunit ribosomal protein L1; Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release. | 0.474 |
argS | tatA | SAMN02745193_01504 | SAMN02745193_01509 | arginyl-tRNA synthetase. | Sec-independent protein translocase protein TatA; Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin- arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system. | 0.443 |
argS | tuf | SAMN02745193_01504 | SAMN02745193_02214 | arginyl-tRNA synthetase. | Translation elongation factor 1A (EF-1A/EF-Tu); This protein promotes the GTP-dependent binding of aminoacyl- tRNA to the A-site of ribosomes during protein biosynthesis. | 0.409 |
guaA | apt | SAMN02745193_01922 | SAMN02745193_02531 | GMP synthase (glutamine-hydrolyzing); Catalyzes the synthesis of GMP from XMP. | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | 0.988 |
guaA | argS | SAMN02745193_01922 | SAMN02745193_01504 | GMP synthase (glutamine-hydrolyzing); Catalyzes the synthesis of GMP from XMP. | arginyl-tRNA synthetase. | 0.958 |
guaA | guaB | SAMN02745193_01922 | SAMN02745193_01817 | GMP synthase (glutamine-hydrolyzing); Catalyzes the synthesis of GMP from XMP. | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | 0.998 |
guaA | map | SAMN02745193_01922 | SAMN02745193_00008 | GMP synthase (glutamine-hydrolyzing); Catalyzes the synthesis of GMP from XMP. | Methionine aminopeptidase, type I; Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). Requires deformylation of the N(alpha)-formylated initiator methionine before it can be hydrolyzed; Belongs to the peptidase M24A family. Methionine aminopeptidase type 1 subfamily. | 0.944 |
guaA | pyrG | SAMN02745193_01922 | SAMN02745193_01045 | GMP synthase (glutamine-hydrolyzing); Catalyzes the synthesis of GMP from XMP. | CTP synthase; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates. | 0.974 |
guaA | rimM | SAMN02745193_01922 | SAMN02745193_01748 | GMP synthase (glutamine-hydrolyzing); Catalyzes the synthesis of GMP from XMP. | 16S rRNA processing protein RimM; An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes; Belongs to the RimM family. | 0.950 |
guaA | rplA | SAMN02745193_01922 | SAMN02745193_02292 | GMP synthase (glutamine-hydrolyzing); Catalyzes the synthesis of GMP from XMP. | Large subunit ribosomal protein L1; Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release. | 0.958 |
guaA | tatA | SAMN02745193_01922 | SAMN02745193_01509 | GMP synthase (glutamine-hydrolyzing); Catalyzes the synthesis of GMP from XMP. | Sec-independent protein translocase protein TatA; Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin- arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system. | 0.944 |
guaA | truB | SAMN02745193_01922 | SAMN02745193_02780 | GMP synthase (glutamine-hydrolyzing); Catalyzes the synthesis of GMP from XMP. | tRNA pseudouridine synthase B; Responsible for synthesis of pseudouridine from uracil-55 in the psi GC loop of transfer RNAs; Belongs to the pseudouridine synthase TruB family. Type 1 subfamily. | 0.947 |
guaA | tuf | SAMN02745193_01922 | SAMN02745193_02214 | GMP synthase (glutamine-hydrolyzing); Catalyzes the synthesis of GMP from XMP. | Translation elongation factor 1A (EF-1A/EF-Tu); This protein promotes the GTP-dependent binding of aminoacyl- tRNA to the A-site of ribosomes during protein biosynthesis. | 0.958 |
guaB | apt | SAMN02745193_01817 | SAMN02745193_02531 | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | 0.856 |