node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
AKS37184.1 | AKS38553.1 | AFK25_01025 | AFK25_08285 | hydroxymethylglutaryl-CoA lyase. | Acetolactate synthase; Belongs to the TPP enzyme family. | 0.568 |
AKS37184.1 | AKS39128.1 | AFK25_01025 | AFK25_11185 | hydroxymethylglutaryl-CoA lyase. | Acetolactate synthase. | 0.641 |
AKS37184.1 | AKS39129.1 | AFK25_01025 | AFK25_11190 | hydroxymethylglutaryl-CoA lyase. | Acetolactate synthase catalytic subunit; Catalyzes the formation of 2-acetolactate from pyruvate; also known as acetolactate synthase large subunit. | 0.479 |
AKS37184.1 | AKS39386.1 | AFK25_01025 | AFK25_12625 | hydroxymethylglutaryl-CoA lyase. | Homoserine dehydrogenase. | 0.880 |
AKS37184.1 | ilvC | AFK25_01025 | AFK25_11180 | hydroxymethylglutaryl-CoA lyase. | Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. | 0.800 |
AKS37184.1 | ilvD | AFK25_01025 | AFK25_08320 | hydroxymethylglutaryl-CoA lyase. | Dihydroxy-acid dehydratase; Belongs to the IlvD/Edd family. | 0.744 |
AKS37184.1 | leuB | AFK25_01025 | AFK25_11170 | hydroxymethylglutaryl-CoA lyase. | 3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. | 0.817 |
AKS37184.1 | leuC | AFK25_01025 | AFK25_11165 | hydroxymethylglutaryl-CoA lyase. | Isopropylmalate isomerase; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. | 0.805 |
AKS37184.1 | leuD | AFK25_01025 | AFK25_11160 | hydroxymethylglutaryl-CoA lyase. | Isopropylmalate isomerase; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 1 subfamily. | 0.804 |
AKS38553.1 | AKS37184.1 | AFK25_08285 | AFK25_01025 | Acetolactate synthase; Belongs to the TPP enzyme family. | hydroxymethylglutaryl-CoA lyase. | 0.568 |
AKS38553.1 | AKS39128.1 | AFK25_08285 | AFK25_11185 | Acetolactate synthase; Belongs to the TPP enzyme family. | Acetolactate synthase. | 0.996 |
AKS38553.1 | AKS39129.1 | AFK25_08285 | AFK25_11190 | Acetolactate synthase; Belongs to the TPP enzyme family. | Acetolactate synthase catalytic subunit; Catalyzes the formation of 2-acetolactate from pyruvate; also known as acetolactate synthase large subunit. | 0.916 |
AKS38553.1 | AKS39386.1 | AFK25_08285 | AFK25_12625 | Acetolactate synthase; Belongs to the TPP enzyme family. | Homoserine dehydrogenase. | 0.990 |
AKS38553.1 | ilvC | AFK25_08285 | AFK25_11180 | Acetolactate synthase; Belongs to the TPP enzyme family. | Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. | 0.991 |
AKS38553.1 | ilvD | AFK25_08285 | AFK25_08320 | Acetolactate synthase; Belongs to the TPP enzyme family. | Dihydroxy-acid dehydratase; Belongs to the IlvD/Edd family. | 0.932 |
AKS38553.1 | leuA | AFK25_08285 | AFK25_11175 | Acetolactate synthase; Belongs to the TPP enzyme family. | 2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily. | 0.941 |
AKS38553.1 | leuB | AFK25_08285 | AFK25_11170 | Acetolactate synthase; Belongs to the TPP enzyme family. | 3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. | 0.976 |
AKS38553.1 | leuC | AFK25_08285 | AFK25_11165 | Acetolactate synthase; Belongs to the TPP enzyme family. | Isopropylmalate isomerase; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. | 0.681 |
AKS38553.1 | leuD | AFK25_08285 | AFK25_11160 | Acetolactate synthase; Belongs to the TPP enzyme family. | Isopropylmalate isomerase; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 1 subfamily. | 0.708 |
AKS39128.1 | AKS37184.1 | AFK25_11185 | AFK25_01025 | Acetolactate synthase. | hydroxymethylglutaryl-CoA lyase. | 0.641 |