node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
dxs | thiG | Dda3937_01960 | Dda3937_00231 | 1-deoxyxylulose-5-phosphate synthase, thiamine-requiring, FAD-requiring; Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D- xylulose-5-phosphate (DXP); Belongs to the transketolase family. DXPS subfamily. | Thiamin biosynthesis ThiGH complex subunit; Catalyzes the rearrangement of 1-deoxy-D-xylulose 5-phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S. | 0.930 |
dxs | thiI | Dda3937_01960 | Dda3937_01963 | 1-deoxyxylulose-5-phosphate synthase, thiamine-requiring, FAD-requiring; Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D- xylulose-5-phosphate (DXP); Belongs to the transketolase family. DXPS subfamily. | Sulfur transfer protein; Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS. | 0.671 |
moaD | moeB | Dda3937_03764 | Dda3937_03739 | Molybdopterin synthase, small subunit; Protein involved in Mo-molybdopterin cofactor biosynthetic process and sulfur metabolic process. | Molybdopterin synthase sulfurylase; Protein involved in catalytic activity and Mo-molybdopterin cofactor biosynthetic process. | 0.988 |
moaD | thiF | Dda3937_03764 | Dda3937_00233 | Molybdopterin synthase, small subunit; Protein involved in Mo-molybdopterin cofactor biosynthetic process and sulfur metabolic process. | Thiamin (thiazole moiety) biosynthesis protein; Protein involved in catalytic activity and thiamin biosynthetic process. | 0.753 |
moaD | thiG | Dda3937_03764 | Dda3937_00231 | Molybdopterin synthase, small subunit; Protein involved in Mo-molybdopterin cofactor biosynthetic process and sulfur metabolic process. | Thiamin biosynthesis ThiGH complex subunit; Catalyzes the rearrangement of 1-deoxy-D-xylulose 5-phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S. | 0.762 |
moaD | thiI | Dda3937_03764 | Dda3937_01963 | Molybdopterin synthase, small subunit; Protein involved in Mo-molybdopterin cofactor biosynthetic process and sulfur metabolic process. | Sulfur transfer protein; Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS. | 0.420 |
moeB | moaD | Dda3937_03739 | Dda3937_03764 | Molybdopterin synthase sulfurylase; Protein involved in catalytic activity and Mo-molybdopterin cofactor biosynthetic process. | Molybdopterin synthase, small subunit; Protein involved in Mo-molybdopterin cofactor biosynthetic process and sulfur metabolic process. | 0.988 |
moeB | thiC | Dda3937_03739 | Dda3937_00235 | Molybdopterin synthase sulfurylase; Protein involved in catalytic activity and Mo-molybdopterin cofactor biosynthetic process. | Thiamin (pyrimidine moiety) biosynthesis protein; Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction. | 0.677 |
moeB | thiD | Dda3937_03739 | Dda3937_02807 | Molybdopterin synthase sulfurylase; Protein involved in catalytic activity and Mo-molybdopterin cofactor biosynthetic process. | Bifunctional hydroxy-methylpyrimidine kinase/hydroxy-phosphomethylpyrimidine kinase; Protein involved in phosphomethylpyrimidine kinase activity and thiamin biosynthetic process. | 0.660 |
moeB | thiE | Dda3937_03739 | Dda3937_00234 | Molybdopterin synthase sulfurylase; Protein involved in catalytic activity and Mo-molybdopterin cofactor biosynthetic process. | Thiamin phosphate synthase (thiamin phosphate pyrophosphorylase); Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP). Belongs to the thiamine-phosphate synthase family. | 0.689 |
moeB | thiG | Dda3937_03739 | Dda3937_00231 | Molybdopterin synthase sulfurylase; Protein involved in catalytic activity and Mo-molybdopterin cofactor biosynthetic process. | Thiamin biosynthesis ThiGH complex subunit; Catalyzes the rearrangement of 1-deoxy-D-xylulose 5-phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S. | 0.864 |
moeB | thiH | Dda3937_03739 | Dda3937_00230 | Molybdopterin synthase sulfurylase; Protein involved in catalytic activity and Mo-molybdopterin cofactor biosynthetic process. | Thiamin biosynthesis ThiGH complex subunit; Protein involved in catalytic activity, iron-sulfur cluster binding, biotin synthase activity, iron ion binding, 4 iron, 4 sulfur cluster binding, thiamin biosynthetic process, biotin biosynthetic process and metabolic process. | 0.640 |
moeB | thiI | Dda3937_03739 | Dda3937_01963 | Molybdopterin synthase sulfurylase; Protein involved in catalytic activity and Mo-molybdopterin cofactor biosynthetic process. | Sulfur transfer protein; Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS. | 0.480 |
moeB | thiS | Dda3937_03739 | Dda3937_00232 | Molybdopterin synthase sulfurylase; Protein involved in catalytic activity and Mo-molybdopterin cofactor biosynthetic process. | Thiamin biosynthesis protein, sulfur donor; Protein involved in thiamin biosynthetic process and sulfur metabolic process. | 0.855 |
thiC | moeB | Dda3937_00235 | Dda3937_03739 | Thiamin (pyrimidine moiety) biosynthesis protein; Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction. | Molybdopterin synthase sulfurylase; Protein involved in catalytic activity and Mo-molybdopterin cofactor biosynthetic process. | 0.677 |
thiC | thiD | Dda3937_00235 | Dda3937_02807 | Thiamin (pyrimidine moiety) biosynthesis protein; Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction. | Bifunctional hydroxy-methylpyrimidine kinase/hydroxy-phosphomethylpyrimidine kinase; Protein involved in phosphomethylpyrimidine kinase activity and thiamin biosynthetic process. | 0.996 |
thiC | thiE | Dda3937_00235 | Dda3937_00234 | Thiamin (pyrimidine moiety) biosynthesis protein; Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction. | Thiamin phosphate synthase (thiamin phosphate pyrophosphorylase); Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP). Belongs to the thiamine-phosphate synthase family. | 0.994 |
thiC | thiF | Dda3937_00235 | Dda3937_00233 | Thiamin (pyrimidine moiety) biosynthesis protein; Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction. | Thiamin (thiazole moiety) biosynthesis protein; Protein involved in catalytic activity and thiamin biosynthetic process. | 0.983 |
thiC | thiG | Dda3937_00235 | Dda3937_00231 | Thiamin (pyrimidine moiety) biosynthesis protein; Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction. | Thiamin biosynthesis ThiGH complex subunit; Catalyzes the rearrangement of 1-deoxy-D-xylulose 5-phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S. | 0.995 |
thiC | thiH | Dda3937_00235 | Dda3937_00230 | Thiamin (pyrimidine moiety) biosynthesis protein; Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction. | Thiamin biosynthesis ThiGH complex subunit; Protein involved in catalytic activity, iron-sulfur cluster binding, biotin synthase activity, iron ion binding, 4 iron, 4 sulfur cluster binding, thiamin biosynthetic process, biotin biosynthetic process and metabolic process. | 0.987 |