STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
thiSThiamin biosynthesis protein, sulfur donor; Protein involved in thiamin biosynthetic process and sulfur metabolic process. (66 aa)    
Predicted Functional Partners:
thiF
Thiamin (thiazole moiety) biosynthesis protein; Protein involved in catalytic activity and thiamin biosynthetic process.
 
 0.998
thiG
Thiamin biosynthesis ThiGH complex subunit; Catalyzes the rearrangement of 1-deoxy-D-xylulose 5-phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S.
 
 
 0.996
thiE
Thiamin phosphate synthase (thiamin phosphate pyrophosphorylase); Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP). Belongs to the thiamine-phosphate synthase family.
  
  
 0.968
thiC
Thiamin (pyrimidine moiety) biosynthesis protein; Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction.
  
  
 0.964
thiH
Thiamin biosynthesis ThiGH complex subunit; Protein involved in catalytic activity, iron-sulfur cluster binding, biotin synthase activity, iron ion binding, 4 iron, 4 sulfur cluster binding, thiamin biosynthetic process, biotin biosynthetic process and metabolic process.
 
  
 0.961
moeB
Molybdopterin synthase sulfurylase; Protein involved in catalytic activity and Mo-molybdopterin cofactor biosynthetic process.
  
 
 0.855
thiD
Bifunctional hydroxy-methylpyrimidine kinase/hydroxy-phosphomethylpyrimidine kinase; Protein involved in phosphomethylpyrimidine kinase activity and thiamin biosynthetic process.
  
    0.835
ttcA
Putative tRNA 2-thiocytidine (s(2)C32) synthase; Catalyzes the ATP-dependent 2-thiolation of cytidine in position 32 of tRNA, to form 2-thiocytidine (s(2)C32). The sulfur atoms are provided by the cysteine/cysteine desulfurase (IscS) system.
  
 
 0.666
tilS
tRNA(Ile)-lysidine synthetase; Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine. Belongs to the tRNA(Ile)-lysidine synthase family.
  
 
 0.660
ADM96262.1
Long-chain-fatty-acid--CoA ligase / long-chain acyl-CoA synthetase; Protein involved in (DEPRECATED) molecular function unknown and (DEPRECATED) biological process unknown.
  
    0.605
Your Current Organism:
Dickeya dadantii
NCBI taxonomy Id: 198628
Other names: D. dadantii 3937, Dickeya dadantii 3937, Dickeya dadantii str. 3937, Dickeya dadantii strain 3937, Erwinia chrysanthemi str. 3937, Pectobacterium chrysanthemi str. 3937
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