node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
copA | dnaJ | Dda3937_04159 | Dda3937_00384 | Lead, cadmium, zinc and mercury transporting ATPase; Protein involved in ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism, ATP binding, copper-exporting ATPase activity, metal ion binding, hydrolase activity, hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances, catalytic activity, metal ion transmembrane transporter activity, transport, copper ion transport, metal ion transport and metabolic process. | Chaperone Hsp40, co-chaperone with DnaK; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interaction [...] | 0.417 |
copA | zntA | Dda3937_04159 | Dda3937_02650 | Lead, cadmium, zinc and mercury transporting ATPase; Protein involved in ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism, ATP binding, copper-exporting ATPase activity, metal ion binding, hydrolase activity, hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances, catalytic activity, metal ion transmembrane transporter activity, transport, copper ion transport, metal ion transport and metabolic process. | Zinc, cobalt and lead efflux system; Protein involved in ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism, ATP binding, hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides, metal ion binding, metal ion transmembrane transporter activity, hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances, catalytic activity, cation channel activity, ATP synthesis coupled proton transport, xenobiotic metabolic process, metal ion transport, transport, metabolic process and cation transport. | 0.896 |
copA | zntR | Dda3937_04159 | Dda3937_02649 | Lead, cadmium, zinc and mercury transporting ATPase; Protein involved in ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism, ATP binding, copper-exporting ATPase activity, metal ion binding, hydrolase activity, hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances, catalytic activity, metal ion transmembrane transporter activity, transport, copper ion transport, metal ion transport and metabolic process. | Regulatory protein, MerR; Protein involved in transcription activator activity, transcription factor activity, transcription, xenobiotic metabolic process and regulation of transcription, DNA-dependent. | 0.585 |
dnaJ | copA | Dda3937_00384 | Dda3937_04159 | Chaperone Hsp40, co-chaperone with DnaK; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interaction [...] | Lead, cadmium, zinc and mercury transporting ATPase; Protein involved in ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism, ATP binding, copper-exporting ATPase activity, metal ion binding, hydrolase activity, hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances, catalytic activity, metal ion transmembrane transporter activity, transport, copper ion transport, metal ion transport and metabolic process. | 0.417 |
dnaJ | rpoA | Dda3937_00384 | Dda3937_01515 | Chaperone Hsp40, co-chaperone with DnaK; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interaction [...] | DNA-directed RNA polymerase alpha subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. | 0.489 |
dnaJ | rpoB | Dda3937_00384 | Dda3937_00220 | Chaperone Hsp40, co-chaperone with DnaK; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interaction [...] | RNA polymerase, beta subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. | 0.488 |
dnaJ | rpoC | Dda3937_00384 | Dda3937_00221 | Chaperone Hsp40, co-chaperone with DnaK; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interaction [...] | RNA polymerase, beta prime subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. | 0.571 |
dnaJ | rpoD | Dda3937_00384 | Dda3937_03534 | Chaperone Hsp40, co-chaperone with DnaK; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interaction [...] | RNA polymerase, sigma 70 (sigma D) factor; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth. | 0.688 |
dnaJ | zntR | Dda3937_00384 | Dda3937_02649 | Chaperone Hsp40, co-chaperone with DnaK; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interaction [...] | Regulatory protein, MerR; Protein involved in transcription activator activity, transcription factor activity, transcription, xenobiotic metabolic process and regulation of transcription, DNA-dependent. | 0.808 |
glnA | zntR | Dda3937_01118 | Dda3937_02649 | Glutamine synthetase; Protein involved in glutamate-ammonia ligase activity, catalytic activity, glutamine biosynthetic process, nitrogen compound metabolic process and nitrogen fixation. | Regulatory protein, MerR; Protein involved in transcription activator activity, transcription factor activity, transcription, xenobiotic metabolic process and regulation of transcription, DNA-dependent. | 0.612 |
rpoA | dnaJ | Dda3937_01515 | Dda3937_00384 | DNA-directed RNA polymerase alpha subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. | Chaperone Hsp40, co-chaperone with DnaK; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interaction [...] | 0.489 |
rpoA | rpoB | Dda3937_01515 | Dda3937_00220 | DNA-directed RNA polymerase alpha subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. | RNA polymerase, beta subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. | 0.998 |
rpoA | rpoC | Dda3937_01515 | Dda3937_00221 | DNA-directed RNA polymerase alpha subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. | RNA polymerase, beta prime subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. | 0.998 |
rpoA | rpoD | Dda3937_01515 | Dda3937_03534 | DNA-directed RNA polymerase alpha subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. | RNA polymerase, sigma 70 (sigma D) factor; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth. | 0.967 |
rpoA | rpoZ | Dda3937_01515 | Dda3937_01128 | DNA-directed RNA polymerase alpha subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. | RNA polymerase, omega subunit; Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits. | 0.997 |
rpoA | yhdN | Dda3937_01515 | Dda3937_01517 | DNA-directed RNA polymerase alpha subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. | Putative cytoplasmic protein; Protein involved in (DEPRECATED) molecular function unknown and (DEPRECATED) biological process unknown. | 0.429 |
rpoA | zntR | Dda3937_01515 | Dda3937_02649 | DNA-directed RNA polymerase alpha subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. | Regulatory protein, MerR; Protein involved in transcription activator activity, transcription factor activity, transcription, xenobiotic metabolic process and regulation of transcription, DNA-dependent. | 0.650 |
rpoB | dnaJ | Dda3937_00220 | Dda3937_00384 | RNA polymerase, beta subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. | Chaperone Hsp40, co-chaperone with DnaK; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interaction [...] | 0.488 |
rpoB | rpoA | Dda3937_00220 | Dda3937_01515 | RNA polymerase, beta subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. | DNA-directed RNA polymerase alpha subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. | 0.998 |
rpoB | rpoC | Dda3937_00220 | Dda3937_00221 | RNA polymerase, beta subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. | RNA polymerase, beta prime subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. | 0.999 |