STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
metLBifunctional aspartokinase/homoserine dehydrogenase; Protein involved in aspartate kinase activity, homoserine dehydrogenase activity, methionine biosynthetic process, homoserine biosynthetic process, amino acid biosynthetic process and aspartate family amino acid biosynthetic process. (811 aa)    
Predicted Functional Partners:
thrB
Homoserine kinase; Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate; Belongs to the GHMP kinase family. Homoserine kinase subfamily.
 
 0.998
asd
Aspartate-semialdehyde dehydrogenase, NAD(P)-binding protein; Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl- 4-phosphate; Belongs to the aspartate-semialdehyde dehydrogenase family.
  
 0.991
thrA
Bifunctional aspartokinase I/homoserine dehydrogenase I; Protein involved in aspartate kinase activity, homoserine dehydrogenase activity, amino acid binding, threonine biosynthetic process, homoserine biosynthetic process, amino acid biosynthetic process, aspartate family amino acid biosynthetic process and metabolic process.
 
0.990
metB
Cystathionine gamma-synthase; Protein involved in catalytic activity, pyridoxal phosphate binding, methionine biosynthetic process and amino acid metabolic process.
  
 
 0.987
thrC
Threonine synthase; Protein involved in catalytic activity, threonine synthase activity, threonine biosynthetic process, metabolic process and amino acid metabolic process.
 
 
 0.979
metA
Homoserine transsuccinylase; Transfers a succinyl group from succinyl-CoA to L-homoserine, forming succinyl-L-homoserine; Belongs to the MetA family.
  
 
 0.966
usg
Protein involved in aspartate-semialdehyde dehydrogenase activity, NADP binding, oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor, NAD binding, protein dimerization activity, amino acid biosynthetic process and amino acid metabolic process.
 
 0.964
metH
homocysteine-N5-methyltetrahydrofolate transmethylase, B12-dependent; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate.
  
 
 0.960
lysC
Aspartokinase III; Protein involved in aspartate kinase activity, amino acid binding, lysine biosynthetic process via diaminopimelate, homoserine biosynthetic process, biosynthetic process, amino acid biosynthetic process and metabolic process; Belongs to the aspartokinase family.
 
0.956
ADM96615.1
Protein involved in O-acetyltransferase activity and methionine biosynthetic process; Belongs to the AB hydrolase superfamily. MetX family.
  
 
 0.948
Your Current Organism:
Dickeya dadantii
NCBI taxonomy Id: 198628
Other names: D. dadantii 3937, Dickeya dadantii 3937, Dickeya dadantii str. 3937, Dickeya dadantii strain 3937, Erwinia chrysanthemi str. 3937, Pectobacterium chrysanthemi str. 3937
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.