STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
ompAOuter membrane protein A precursor; With TolR probably plays a role in maintaining the position of the peptidoglycan cell wall in the periplasm. Acts as a porin with low permeability that allows slow penetration of small solutes; an internal gate slows down solute passage; Belongs to the outer membrane OOP (TC 1.B.6) superfamily. OmpA family. (347 aa)    
Predicted Functional Partners:
ompF
Outer membrane protein F precursor; Forms pores that allow passive diffusion of small molecules across the membrane.
  
 0.966
htrA
Periplasmic serine protease; Might be efficient in the degradation of transiently denatured and unfolded proteins which accumulate in the periplasm following stress conditions.
    
 
 0.956
yaeT
Unknown protein from 2d-page spots m62/m63/; Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane.
  
 
 
 0.948
secA
Preprotein translocase SecA subunit; Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving both as a receptor for the preprotein-SecB complex and as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane. Belongs to the SecA family.
    
 
 0.925
lepB
Signal peptidase I; Belongs to the peptidase S26 family.
 
  
 0.858
flgE
Flagellar hook protein FlgE.
   
 
 0.857
flgC
Flagellar basal-body rod protein FlgC; Belongs to the flagella basal body rod proteins family.
   
   0.813
flgG
Flagellar basal-body rod protein FlgG; Belongs to the flagella basal body rod proteins family.
   
   0.796
gyrB
DNA gyrase subunit B; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.
     
 0.752
fliE
Flagellar hook-basal body complex protein FliE.
   
   0.746
Your Current Organism:
Buchnera aphidicola Sg
NCBI taxonomy Id: 198804
Other names: B. aphidicola str. Sg (Schizaphis graminum), Buchnera aphidicola str. Sg (Schizaphis graminum)
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