ENSCPUP00000016910 protein (Calidris pugnax)

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second shell of interactors

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Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

Your Input:

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Gene Fusion

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Coexpression

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Score

ENSCPUP00000016910

annotation not available (349 aa)

Predicted Functional Partners:

WDR33

0.979

CPSF2

0.966

CPSF3

0.966

CSTF2

0.965

LOC106887667

0.964

WDR82

0.962

CSTF3

0.962

SYMPK

0.954

NUDT21

0.949

PCF11

0.935

Your Current Organism:

Calidris pugnax

NCBI taxonomy Id: 198806
Other names: C. pugnax, Machetes pugnax, Pavoncella pugnax, Philomachus pugnax, ruff

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CPSF2	CPSF3	ENSCPUP00000001009	ENSCPUP00000004813	Cleavage and polyadenylation specific factor 2.	Cleavage and polyadenylation specific factor 3.	0.999
CPSF2	CSTF2	ENSCPUP00000001009	ENSCPUP00000008257	Cleavage and polyadenylation specific factor 2.	Cleavage stimulation factor subunit 2.	0.998
CPSF2	CSTF3	ENSCPUP00000001009	ENSCPUP00000025359	Cleavage and polyadenylation specific factor 2.	Cleavage stimulation factor subunit 3.	0.989
CPSF2	ENSCPUP00000016910	ENSCPUP00000001009	ENSCPUP00000016910	Cleavage and polyadenylation specific factor 2.	annotation not available	0.966
CPSF2	LOC106887667	ENSCPUP00000001009	ENSCPUP00000014422	Cleavage and polyadenylation specific factor 2.	RNA polymerase II subunit A C-terminal domain phosphatase SSU72.	0.998
CPSF2	NUDT21	ENSCPUP00000001009	ENSCPUP00000016524	Cleavage and polyadenylation specific factor 2.	Nudix hydrolase 21.	0.971
CPSF2	PCF11	ENSCPUP00000001009	ENSCPUP00000000058	Cleavage and polyadenylation specific factor 2.	PCF11 cleavage and polyadenylation factor subunit.	0.998
CPSF2	SYMPK	ENSCPUP00000001009	ENSCPUP00000023135	Cleavage and polyadenylation specific factor 2.	Symplekin.	0.999
CPSF2	WDR33	ENSCPUP00000001009	ENSCPUP00000028043	Cleavage and polyadenylation specific factor 2.	WD repeat domain 33.	0.999
CPSF2	WDR82	ENSCPUP00000001009	ENSCPUP00000009700	Cleavage and polyadenylation specific factor 2.	WD repeat domain 82.	0.998
CPSF3	CPSF2	ENSCPUP00000004813	ENSCPUP00000001009	Cleavage and polyadenylation specific factor 3.	Cleavage and polyadenylation specific factor 2.	0.999
CPSF3	CSTF2	ENSCPUP00000004813	ENSCPUP00000008257	Cleavage and polyadenylation specific factor 3.	Cleavage stimulation factor subunit 2.	0.998
CPSF3	CSTF3	ENSCPUP00000004813	ENSCPUP00000025359	Cleavage and polyadenylation specific factor 3.	Cleavage stimulation factor subunit 3.	0.992
CPSF3	ENSCPUP00000016910	ENSCPUP00000004813	ENSCPUP00000016910	Cleavage and polyadenylation specific factor 3.	annotation not available	0.966
CPSF3	LOC106887667	ENSCPUP00000004813	ENSCPUP00000014422	Cleavage and polyadenylation specific factor 3.	RNA polymerase II subunit A C-terminal domain phosphatase SSU72.	0.998
CPSF3	NUDT21	ENSCPUP00000004813	ENSCPUP00000016524	Cleavage and polyadenylation specific factor 3.	Nudix hydrolase 21.	0.969
CPSF3	PCF11	ENSCPUP00000004813	ENSCPUP00000000058	Cleavage and polyadenylation specific factor 3.	PCF11 cleavage and polyadenylation factor subunit.	0.998
CPSF3	SYMPK	ENSCPUP00000004813	ENSCPUP00000023135	Cleavage and polyadenylation specific factor 3.	Symplekin.	0.999
CPSF3	WDR33	ENSCPUP00000004813	ENSCPUP00000028043	Cleavage and polyadenylation specific factor 3.	WD repeat domain 33.	0.999
CPSF3	WDR82	ENSCPUP00000004813	ENSCPUP00000009700	Cleavage and polyadenylation specific factor 3.	WD repeat domain 82.	0.998

page 1 of 6

Network Stats

number of nodes:

5

number of edges:

5

average node degree:

2

avg. local clustering coefficient:

0.833

expected number of edges:

4

PPI enrichment p-value:

0.377

your network does not have significantly more
interactions than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0006072

glycerol-3-phosphate metabolic process

5 of 12

2.91

5.03

4.40e-10

GO:0019432

Triglyceride biosynthetic process

4 of 13

2.77

3.76

1.03e-07

GO:0006654

Phosphatidic acid biosynthetic process

4 of 17

2.66

3.55

2.15e-07

GO:0008654

Phospholipid biosynthetic process

7 of 183

1.87

3.48

2.42e-09

GO:0046486

Glycerolipid metabolic process

8 of 318

1.69

3.11

1.24e-09

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0008374

O-acyltransferase activity

8 of 49

2.5

7.29

7.90e-16

GO:0003841

1-acylglycerol-3-phosphate O-acyltransferase activity

5 of 11

2.94

5.55

4.61e-11

GO:0004366

glycerol-3-phosphate O-acyltransferase activity

4 of 5

3.19

4.79

1.85e-09

GO:0102420

sn-1-glycerol-3-phosphate C16:0-DCA-CoA acyl transferase activity

2 of 2

3.29

1.86

0.00044

GO:0003824

Catalytic activity

11 of 5987

0.55

0.46

0.00030

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0009331

glycerol-3-phosphate dehydrogenase complex

2 of 4

2.99

1.24

0.0057

Reference Publications (PubMed)

publication

(year) title

count in network

strength

signal

false discovery rate

PMID:31159297

(2019) Functional Analysis of Genes Involved in Glycerolipids Biosynthesis (GPAT1 and GPAT2) in Pigs.

4 of 14

2.74

2.79

7.12e-06

PMID:38003015

(2023) Role of Different Members of the AGPAT Gene Family in Milk Fat Synthesis in Bubalus bubalis.

4 of 17

2.66

2.77

7.12e-06

PMID:29724161

(2018) Transcriptional profiling of swine mammary gland during the transition from colostrogenesis to lactogenesis using RNA sequencing.

5 of 95

2.01

2.29

1.89e-05

PMID:28455945

(2017) The influence of delipidation on triglyceride and LIPIN1 of porcine embryos derived from parthenogenetic activation.

3 of 6

2.99

2.14

0.00013

PMID:36108237

(2022) Identification of a missense variant in the porcine AGPAT gene family associated with intramuscular fat content through whole-genome sequencing.

3 of 8

2.86

2.03

0.00020

(more ...)

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:10409

Glycerophospholipid metabolism

10 of 31

2.8

11.45

1.04e-23

CL:10458

glycerol-3-phosphate O-acyltransferase activity, and glycerol-3-phosphate catabolic process

6 of 6

3.29

7.99

2.10e-15

CL:10411

Glycerolipid metabolism

3 of 19

2.48

2.17

8.74e-05

CL:10412

Mixed, incl. Acyltransferase C-terminus, and Diacylglycerol diphosphate phosphatase activity

2 of 11

2.55

1.14

0.0084

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

ssc00564

Glycerophospholipid metabolism

11 of 84

2.4

10.09

2.53e-24

ssc00561

Glycerolipid metabolism

7 of 53

2.41

6.33

5.31e-14

ssc01100

Metabolic pathways

8 of 1250

1.09

1.26

2.25e-06

ssc04975

Fat digestion and absorption

2 of 37

2.02

0.97

0.0147

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

SSC-1483166

Synthesis of PA

10 of 38

2.71

11.04

2.18e-23

SSC-1430728

Metabolism

11 of 1426

1.17

1.77

4.08e-11

SSC-75109

Triglyceride biosynthesis

2 of 11

2.55

1.26

0.0050

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0009331

glycerol-3-phosphate dehydrogenase complex

2 of 4

2.99

1.18

0.0073

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0012

Acyltransferase

4 of 73

2.03

2.26

2.30e-05

KW-0594

Phospholipid biosynthesis

2 of 10

2.59

1.34

0.0036

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF07479

NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus

2 of 3

3.11

1.26

0.0054

PF01210

NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus

2 of 3

3.11

1.26

0.0054

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR002123

Phospholipid/glycerol acyltransferase

8 of 14

3.04

9.79

3.12e-19

IPR022284

Glycerol-3-phosphate O-acyltransferase/Dihydroxyacetone phosphate acyltransferase

3 of 4

3.16

2.73

1.11e-05

IPR045520

GPAT/DHAPAT, C-terminal domain

2 of 2

3.29

1.4

0.0030

IPR045252

Lysophosphatidylcholine acyltransferase LPCAT1-like

2 of 4

2.99

1.4

0.0030

IPR041728

GPAT/DHAPAT, acyltransferase domain

2 of 2

3.29

1.4

0.0030

(more ...)

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00563

Phosphate acyltransferases

8 of 19

2.91

9.63

2.83e-19

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