N4BP2L1 protein (Calidris pugnax) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

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Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

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[Homology]

Score

N4BP2L1

NEDD4 binding protein 2 like 1. (127 aa)

Predicted Functional Partners:

PALB2

0.749

NDUFA5

0.728

NDUFV1

0.727

NDUFA6

0.726

NDUFS6

0.720

GSTO1

0.719

NDUFA2

0.713

NDUFA12

0.711

NDUFS1

0.699

NDUFA8

0.695

Your Current Organism:

Calidris pugnax

NCBI taxonomy Id: 198806
Other names: C. pugnax, Machetes pugnax, Pavoncella pugnax, Philomachus pugnax, ruff

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
GSTO1	N4BP2L1	ENSCPUP00000001175	ENSCPUP00000019214	Glutathione S-transferase omega-1-like.	NEDD4 binding protein 2 like 1.	0.719
GSTO1	NDUFA12	ENSCPUP00000001175	ENSCPUP00000003566	Glutathione S-transferase omega-1-like.	NADH:ubiquinone oxidoreductase subunit A12.	0.980
GSTO1	NDUFA2	ENSCPUP00000001175	ENSCPUP00000016118	Glutathione S-transferase omega-1-like.	NADH:ubiquinone oxidoreductase subunit A2.	0.981
GSTO1	NDUFA5	ENSCPUP00000001175	ENSCPUP00000018381	Glutathione S-transferase omega-1-like.	NADH:ubiquinone oxidoreductase subunit A5.	0.980
GSTO1	NDUFA6	ENSCPUP00000001175	ENSCPUP00000001028	Glutathione S-transferase omega-1-like.	NADH:ubiquinone oxidoreductase subunit A6.	0.982
GSTO1	NDUFA8	ENSCPUP00000001175	ENSCPUP00000023687	Glutathione S-transferase omega-1-like.	NADH:ubiquinone oxidoreductase subunit A8.	0.979
GSTO1	NDUFS1	ENSCPUP00000001175	ENSCPUP00000010521	Glutathione S-transferase omega-1-like.	NADH:ubiquinone oxidoreductase core subunit S1.	0.922
GSTO1	NDUFS6	ENSCPUP00000001175	ENSCPUP00000007896	Glutathione S-transferase omega-1-like.	NADH:ubiquinone oxidoreductase subunit S6.	0.980
GSTO1	NDUFV1	ENSCPUP00000001175	ENSCPUP00000011917	Glutathione S-transferase omega-1-like.	NADH:ubiquinone oxidoreductase core subunit V1.	0.980
GSTO1	PALB2	ENSCPUP00000001175	ENSCPUP00000024576	Glutathione S-transferase omega-1-like.	Partner and localizer of BRCA2.	0.897
N4BP2L1	GSTO1	ENSCPUP00000019214	ENSCPUP00000001175	NEDD4 binding protein 2 like 1.	Glutathione S-transferase omega-1-like.	0.719
N4BP2L1	NDUFA12	ENSCPUP00000019214	ENSCPUP00000003566	NEDD4 binding protein 2 like 1.	NADH:ubiquinone oxidoreductase subunit A12.	0.711
N4BP2L1	NDUFA2	ENSCPUP00000019214	ENSCPUP00000016118	NEDD4 binding protein 2 like 1.	NADH:ubiquinone oxidoreductase subunit A2.	0.713
N4BP2L1	NDUFA5	ENSCPUP00000019214	ENSCPUP00000018381	NEDD4 binding protein 2 like 1.	NADH:ubiquinone oxidoreductase subunit A5.	0.728
N4BP2L1	NDUFA6	ENSCPUP00000019214	ENSCPUP00000001028	NEDD4 binding protein 2 like 1.	NADH:ubiquinone oxidoreductase subunit A6.	0.726
N4BP2L1	NDUFA8	ENSCPUP00000019214	ENSCPUP00000023687	NEDD4 binding protein 2 like 1.	NADH:ubiquinone oxidoreductase subunit A8.	0.695
N4BP2L1	NDUFS1	ENSCPUP00000019214	ENSCPUP00000010521	NEDD4 binding protein 2 like 1.	NADH:ubiquinone oxidoreductase core subunit S1.	0.699
N4BP2L1	NDUFS6	ENSCPUP00000019214	ENSCPUP00000007896	NEDD4 binding protein 2 like 1.	NADH:ubiquinone oxidoreductase subunit S6.	0.720
N4BP2L1	NDUFV1	ENSCPUP00000019214	ENSCPUP00000011917	NEDD4 binding protein 2 like 1.	NADH:ubiquinone oxidoreductase core subunit V1.	0.727
N4BP2L1	PALB2	ENSCPUP00000019214	ENSCPUP00000024576	NEDD4 binding protein 2 like 1.	Partner and localizer of BRCA2.	0.749

page 1 of 6

Network Stats

number of nodes:

11

number of edges:

51

average node degree:

9.27

avg. local clustering coefficient:

0.927

expected number of edges:

15

PPI enrichment p-value:

9.33e-14

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0006265

DNA topological change

3 of 10

1.88

0.94

0.0151

GO:0051276

Chromosome organization

4 of 37

1.44

0.84

0.0151

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0003918

DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity

3 of 4

2.28

1.6

0.00098

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005694

Chromosome

3 of 26

1.47

0.79

0.0206

GO:0043232

Intracellular non-membrane-bounded organelle

4 of 92

1.04

0.61

0.0234

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:386

DNA topoisomerase, type IIA-like domain superfamily, and RecF/RecN/SMC, N-terminal

3 of 6

2.11

1.39

0.0022

CL:111

Translation, and Protein export

6 of 165

0.97

0.71

0.0048

CL:113

Translation, and Protein export

5 of 147

0.94

0.58

0.0185

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0009330

DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) complex

2 of 3

2.23

0.79

0.0349

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0799

Topoisomerase

3 of 6

2.11

1.61

0.00075

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR013760

DNA topoisomerase, type IIA-like domain superfamily

3 of 4

2.28

1.5

0.0015

IPR018522

DNA topoisomerase, type IIA, conserved site

2 of 2

2.41

0.77

0.0393

IPR013759

DNA topoisomerase, type IIA, subunit B, C-terminal

2 of 2

2.41

0.77

0.0393

IPR013506

DNA topoisomerase, type IIA, subunit B, domain 2

2 of 2

2.41

0.77

0.0393

IPR002288

DNA gyrase B subunit, C-terminal

2 of 2

2.41

0.77

0.0393

(more ...)

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00433

TopoisomeraseII

2 of 2

2.41

1.12

0.0086

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