SFN79559.1 protein (Actinomadura madurae) - STRING interaction network

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second shell of interactors

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

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Neighborhood

Gene Fusion

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Score

SFN79559.1

DNA-binding response regulator, NarL/FixJ family, contains REC and HTH domains. (219 aa)

Predicted Functional Partners:

SFN79588.1

0.872

SFQ39322.1

0.833

SFQ02925.1

0.799

SFN44556.1

0.792

SFO94049.1

0.792

SFQ32454.1

0.783

SFO49860.1

0.775

SFN16122.1

0.773

SFN83413.1

0.766

SFQ17994.1

0.758

Your Current Organism:

Actinomadura madurae

NCBI taxonomy Id: 1993
Other names: A. madurae, ATCC 19425, CCM 136, CCUG 32944, CECT 3043, CIP 105487, DSM 43067, IAM 14277, IFM 0585, IFO 13909, IFO 14623, IMET 9585, JCM 7436, KCTC 9192, NBRC 14623, NCIMB 13469, NCTC 5654, NRRL B-3843, Nocardia madurae, Streptomyces madurae, Streptothrix madurae, VKM Ac-809

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
SFN16122.1	SFN79559.1	SAMN04489713_101471	SAMN04489713_10366	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase.	DNA-binding response regulator, NarL/FixJ family, contains REC and HTH domains.	0.773
SFN16122.1	SFN79588.1	SAMN04489713_101471	SAMN04489713_10367	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase.	Two-component system, NarL family, sensor histidine kinase UhpB.	0.429
SFN16122.1	SFQ39322.1	SAMN04489713_101471	SAMN04489713_13010	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase.	Hypothetical protein.	0.681
SFN44556.1	SFN79559.1	SAMN04489713_10228	SAMN04489713_10366	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase.	DNA-binding response regulator, NarL/FixJ family, contains REC and HTH domains.	0.792
SFN44556.1	SFN79588.1	SAMN04489713_10228	SAMN04489713_10367	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase.	Two-component system, NarL family, sensor histidine kinase UhpB.	0.408
SFN44556.1	SFQ39322.1	SAMN04489713_10228	SAMN04489713_13010	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase.	Hypothetical protein.	0.681
SFN79559.1	SFN16122.1	SAMN04489713_10366	SAMN04489713_101471	DNA-binding response regulator, NarL/FixJ family, contains REC and HTH domains.	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase.	0.773
SFN79559.1	SFN44556.1	SAMN04489713_10366	SAMN04489713_10228	DNA-binding response regulator, NarL/FixJ family, contains REC and HTH domains.	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase.	0.792
SFN79559.1	SFN79588.1	SAMN04489713_10366	SAMN04489713_10367	DNA-binding response regulator, NarL/FixJ family, contains REC and HTH domains.	Two-component system, NarL family, sensor histidine kinase UhpB.	0.872
SFN79559.1	SFN83413.1	SAMN04489713_10366	SAMN04489713_103180	DNA-binding response regulator, NarL/FixJ family, contains REC and HTH domains.	Signal transduction histidine kinase.	0.766
SFN79559.1	SFO49860.1	SAMN04489713_10366	SAMN04489713_106348	DNA-binding response regulator, NarL/FixJ family, contains REC and HTH domains.	Signal transduction histidine kinase.	0.775
SFN79559.1	SFO94049.1	SAMN04489713_10366	SAMN04489713_110306	DNA-binding response regulator, NarL/FixJ family, contains REC and HTH domains.	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase.	0.792
SFN79559.1	SFQ02925.1	SAMN04489713_10366	SAMN04489713_1216	DNA-binding response regulator, NarL/FixJ family, contains REC and HTH domains.	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase.	0.799
SFN79559.1	SFQ17994.1	SAMN04489713_10366	SAMN04489713_123114	DNA-binding response regulator, NarL/FixJ family, contains REC and HTH domains.	Signal transduction histidine kinase.	0.758
SFN79559.1	SFQ32454.1	SAMN04489713_10366	SAMN04489713_12765	DNA-binding response regulator, NarL/FixJ family, contains REC and HTH domains.	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase.	0.783
SFN79559.1	SFQ39322.1	SAMN04489713_10366	SAMN04489713_13010	DNA-binding response regulator, NarL/FixJ family, contains REC and HTH domains.	Hypothetical protein.	0.833
SFN79588.1	SFN16122.1	SAMN04489713_10367	SAMN04489713_101471	Two-component system, NarL family, sensor histidine kinase UhpB.	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase.	0.429
SFN79588.1	SFN44556.1	SAMN04489713_10367	SAMN04489713_10228	Two-component system, NarL family, sensor histidine kinase UhpB.	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase.	0.408
SFN79588.1	SFN79559.1	SAMN04489713_10367	SAMN04489713_10366	Two-component system, NarL family, sensor histidine kinase UhpB.	DNA-binding response regulator, NarL/FixJ family, contains REC and HTH domains.	0.872
SFN79588.1	SFN83413.1	SAMN04489713_10367	SAMN04489713_103180	Two-component system, NarL family, sensor histidine kinase UhpB.	Signal transduction histidine kinase.	0.427

page 1 of 3

Network Stats

number of nodes:

2

number of edges:

1

average node degree:

1

avg. local clustering coefficient:

1

expected number of edges:

1

PPI enrichment p-value:

0.5

your network does not have significantly more
interactions than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0009252

Peptidoglycan biosynthetic process

8 of 34

2.03

4.81

2.24e-12

GO:0008360

Regulation of cell shape

8 of 49

1.88

4.25

3.90e-12

GO:0071555

Cell wall organization

8 of 59

1.79

3.91

8.16e-12

GO:0051301

Cell division

8 of 66

1.75

3.69

1.56e-11

GO:0007049

Cell cycle

7 of 63

1.71

3.15

1.41e-09

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0016881

Acid-amino acid ligase activity

5 of 17

2.13

3.14

3.12e-07

GO:0047480

UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity

2 of 2

2.66

1.28

0.0047

GO:0008766

UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate-D-alanyl-D-alanine ligase activity

2 of 2

2.66

1.28

0.0047

GO:0043168

Anion binding

7 of 794

0.61

0.36

0.0471

GO:0043167

Ion binding

9 of 1444

0.46

0.29

0.0471

Reference Publications (PubMed)

publication

(year) title

count in network

strength

signal

false discovery rate

PMID:25309529

(2014) L,L-diaminopimelate aminotransferase (DapL): a putative target for the development of narrow-spectrum antibacterial compounds.

2 of 4

2.36

1.07

0.0105

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:1162

Cell shape

8 of 15

2.39

6.72

4.58e-15

CL:1164

Cell shape

7 of 10

2.51

6.47

7.15e-14

CL:1157

Mixed, incl. Cell shape, and Cell division site

9 of 33

2.1

5.82

4.58e-15

CL:1166

MurE/MurF, N-terminal, and UDP-glycosyltransferase activity

5 of 5

2.66

4.92

3.97e-10

CL:1638

Lysine biosynthesis

2 of 5

2.26

1.13

0.0079

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

dsy00550

Peptidoglycan biosynthesis

8 of 29

2.1

5.5

6.05e-14

dsy00300

Lysine biosynthesis

5 of 22

2.02

3.27

6.80e-08

dsy01502

Vancomycin resistance

4 of 14

2.12

2.92

9.39e-07

dsy00471

D-Glutamine and D-glutamate metabolism

2 of 3

2.49

1.65

0.00089

dsy01100

Metabolic pathways

10 of 692

0.82

0.85

8.17e-07

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0573

Peptidoglycan synthesis

8 of 19

2.29

6.37

6.93e-15

KW-0961

Cell wall biogenesis/degradation

8 of 23

2.2

6.09

9.12e-15

KW-0132

Cell division

7 of 31

2.02

4.53

1.23e-11

KW-0131

Cell cycle

7 of 31

2.02

4.53

1.23e-11

KW-0436

Ligase

5 of 73

1.5

1.84

9.57e-06

(more ...)

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF02875

Mur ligase family, glutamate ligase domain

5 of 7

2.52

4.14

9.63e-09

PF08245

Mur ligase middle domain

5 of 9

2.41

4.01

1.21e-08

PF01225

Mur ligase family, catalytic domain

4 of 4

2.66

3.56

2.06e-07

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR036615

Mur ligase, C-terminal domain superfamily

5 of 7

2.52

3.95

2.40e-08

IPR004101

Mur ligase, C-terminal

5 of 7

2.52

3.95

2.40e-08

IPR036565

Mur-like, catalytic domain superfamily

5 of 9

2.41

3.87

2.40e-08

IPR013221

Mur ligase, central

5 of 9

2.41

3.87

2.40e-08

IPR000713

Mur ligase, N-terminal catalytic domain

4 of 4

2.66

3.47

3.08e-07

(more ...)

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