SFO12939.1 protein (Actinomadura madurae) - STRING interaction network

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second shell of interactors

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a 3D structure is known or predicted

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Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

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Gene Fusion

Cooccurrence

Coexpression

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[Homology]

Score

SFO12939.1

Regulatory protein, luxR family. (76 aa)

Predicted Functional Partners:

SFN61231.1

0.683

SFO16227.1

0.683

SFO16979.1

0.683

SFO17283.1

0.683

SFO21466.1

0.683

SFP61014.1

0.683

SFQ15325.1

0.683

SFQ32892.1

0.683

SFO16203.1

0.623

SFO34897.1

0.623

Your Current Organism:

Actinomadura madurae

NCBI taxonomy Id: 1993
Other names: A. madurae, ATCC 19425, CCM 136, CCUG 32944, CECT 3043, CIP 105487, DSM 43067, IAM 14277, IFM 0585, IFO 13909, IFO 14623, IMET 9585, JCM 7436, KCTC 9192, NBRC 14623, NCIMB 13469, NCTC 5654, NRRL B-3843, Nocardia madurae, Streptomyces madurae, Streptothrix madurae, VKM Ac-809

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
SFN61231.1	SFO12939.1	SAMN04489713_102580	SAMN04489713_104203	Regulatory protein, luxR family.	Regulatory protein, luxR family.	0.683
SFO12939.1	SFN61231.1	SAMN04489713_104203	SAMN04489713_102580	Regulatory protein, luxR family.	Regulatory protein, luxR family.	0.683
SFO12939.1	SFO16203.1	SAMN04489713_104203	SAMN04489713_104330	Regulatory protein, luxR family.	Regulatory protein, luxR family.	0.623
SFO12939.1	SFO16227.1	SAMN04489713_104203	SAMN04489713_104331	Regulatory protein, luxR family.	AAA ATPase domain-containing protein.	0.683
SFO12939.1	SFO16979.1	SAMN04489713_104203	SAMN04489713_104357	Regulatory protein, luxR family.	Regulatory protein, luxR family.	0.683
SFO12939.1	SFO17283.1	SAMN04489713_104203	SAMN04489713_104370	Regulatory protein, luxR family.	Regulatory protein, luxR family.	0.683
SFO12939.1	SFO21466.1	SAMN04489713_104203	SAMN04489713_104537	Regulatory protein, luxR family.	Regulatory protein, luxR family.	0.683
SFO12939.1	SFO34897.1	SAMN04489713_104203	SAMN04489713_105185	Regulatory protein, luxR family.	AAA ATPase domain-containing protein.	0.623
SFO12939.1	SFP61014.1	SAMN04489713_104203	SAMN04489713_115215	Regulatory protein, luxR family.	Regulatory protein, luxR family.	0.683
SFO12939.1	SFQ15325.1	SAMN04489713_104203	SAMN04489713_12317	Regulatory protein, luxR family.	Regulatory protein, luxR family.	0.683
SFO12939.1	SFQ32892.1	SAMN04489713_104203	SAMN04489713_12784	Regulatory protein, luxR family.	Regulatory protein, luxR family.	0.683
SFO16203.1	SFO12939.1	SAMN04489713_104330	SAMN04489713_104203	Regulatory protein, luxR family.	Regulatory protein, luxR family.	0.623
SFO16203.1	SFO16227.1	SAMN04489713_104330	SAMN04489713_104331	Regulatory protein, luxR family.	AAA ATPase domain-containing protein.	0.617
SFO16227.1	SFO12939.1	SAMN04489713_104331	SAMN04489713_104203	AAA ATPase domain-containing protein.	Regulatory protein, luxR family.	0.683
SFO16227.1	SFO16203.1	SAMN04489713_104331	SAMN04489713_104330	AAA ATPase domain-containing protein.	Regulatory protein, luxR family.	0.617
SFO16979.1	SFO12939.1	SAMN04489713_104357	SAMN04489713_104203	Regulatory protein, luxR family.	Regulatory protein, luxR family.	0.683
SFO17283.1	SFO12939.1	SAMN04489713_104370	SAMN04489713_104203	Regulatory protein, luxR family.	Regulatory protein, luxR family.	0.683
SFO17283.1	SFP61014.1	SAMN04489713_104370	SAMN04489713_115215	Regulatory protein, luxR family.	Regulatory protein, luxR family.	0.402
SFO21466.1	SFO12939.1	SAMN04489713_104537	SAMN04489713_104203	Regulatory protein, luxR family.	Regulatory protein, luxR family.	0.683
SFO34897.1	SFO12939.1	SAMN04489713_105185	SAMN04489713_104203	AAA ATPase domain-containing protein.	Regulatory protein, luxR family.	0.623

page 1 of 2

Network Stats

number of nodes:

11

number of edges:

35

average node degree:

6.36

avg. local clustering coefficient:

0.876

expected number of edges:

12

PPI enrichment p-value:

1.09e-07

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0006457

Protein folding

6 of 16

2.07

3.55

1.75e-08

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0051082

Unfolded protein binding

5 of 8

2.29

3.5

9.88e-08

GO:0005515

Protein binding

6 of 47

1.6

2.2

1.47e-06

GO:0140662

ATP-dependent protein folding chaperone

2 of 4

2.19

0.97

0.0154

GO:1901363

Heterocyclic compound binding

10 of 966

0.51

0.39

0.0046

GO:0097159

Organic cyclic compound binding

10 of 966

0.51

0.39

0.0046

(more ...)

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:404

Unfolded protein binding, and Chaperone binding

6 of 8

2.37

4.73

2.40e-10

CL:400

Mixed, incl. Chaperone, and Unfolded protein binding

7 of 24

1.96

3.98

2.40e-10

CL:83

Gene expression, and Bacterial secretion system

11 of 185

1.27

2.07

1.28e-11

CL:174

Elongation factor Tu domain 2, and Small ribosomal subunit

2 of 6

2.02

0.9

0.0204

CL:118

Structural constituent of ribosome

3 of 34

1.44

0.81

0.0177

(more ...)

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0042603

Capsule

2 of 2

2.49

1.01

0.0142

GOCC:0015934

Large ribosomal subunit

2 of 7

1.95

0.82

0.0282

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0346

Stress response

3 of 11

1.93

1.4

0.0017

KW-0143

Chaperone

3 of 12

1.89

1.38

0.0017

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