SFO57530.1 protein (Actinomadura madurae) - STRING interaction network

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second shell of interactors

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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protein homology

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Score

SFO57530.1

Hypothetical protein; Belongs to the cytochrome P450 family. (396 aa)

Predicted Functional Partners:

SFO58652.1

0.997

SFO58856.1

0.986

SFP82694.1

0.986

SFQ37819.1

0.984

SFN32920.1

0.983

SFP29557.1

0.983

SFQ36534.1

0.983

SFP29197.1

0.980

SFP29233.1

0.980

SFP31220.1

0.980

Your Current Organism:

Actinomadura madurae

NCBI taxonomy Id: 1993
Other names: A. madurae, ATCC 19425, CCM 136, CCUG 32944, CECT 3043, CIP 105487, DSM 43067, IAM 14277, IFM 0585, IFO 13909, IFO 14623, IMET 9585, JCM 7436, KCTC 9192, NBRC 14623, NCIMB 13469, NCTC 5654, NRRL B-3843, Nocardia madurae, Streptomyces madurae, Streptothrix madurae, VKM Ac-809

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
SFN32920.1	SFO57530.1	SAMN04489713_1011180	SAMN04489713_107226	Amino acid adenylation domain-containing protein.	Hypothetical protein; Belongs to the cytochrome P450 family.	0.983
SFN32920.1	SFO58652.1	SAMN04489713_1011180	SAMN04489713_107279	Amino acid adenylation domain-containing protein.	Methyltransferase domain-containing protein.	0.999
SFN32920.1	SFO58856.1	SAMN04489713_1011180	SAMN04489713_107288	Amino acid adenylation domain-containing protein.	Amino acid adenylation domain-containing protein.	0.999
SFN32920.1	SFP29197.1	SAMN04489713_1011180	SAMN04489713_1132	Amino acid adenylation domain-containing protein.	Methyltransferase, FkbM family/amino acid adenylation domain-containing protein.	0.987
SFN32920.1	SFP29233.1	SAMN04489713_1011180	SAMN04489713_1133	Amino acid adenylation domain-containing protein.	Amino acid adenylation domain-containing protein.	0.988
SFN32920.1	SFP29557.1	SAMN04489713_1011180	SAMN04489713_11314	Amino acid adenylation domain-containing protein.	Nonribosomal peptide synthetase DhbF.	0.998
SFN32920.1	SFP31220.1	SAMN04489713_1011180	SAMN04489713_11368	Amino acid adenylation domain-containing protein.	Pyochelin synthetase; Belongs to the ATP-dependent AMP-binding enzyme family.	0.990
SFN32920.1	SFP82694.1	SAMN04489713_1011180	SAMN04489713_1183	Amino acid adenylation domain-containing protein.	Condensation domain-containing protein.	0.999
SFN32920.1	SFQ36534.1	SAMN04489713_1011180	SAMN04489713_12899	Amino acid adenylation domain-containing protein.	Thioesterase domain-containing protein.	0.998
SFN32920.1	SFQ37819.1	SAMN04489713_1011180	SAMN04489713_12922	Amino acid adenylation domain-containing protein.	8-amino-7-oxononanoate synthase.	0.999
SFO57530.1	SFN32920.1	SAMN04489713_107226	SAMN04489713_1011180	Hypothetical protein; Belongs to the cytochrome P450 family.	Amino acid adenylation domain-containing protein.	0.983
SFO57530.1	SFO58652.1	SAMN04489713_107226	SAMN04489713_107279	Hypothetical protein; Belongs to the cytochrome P450 family.	Methyltransferase domain-containing protein.	0.997
SFO57530.1	SFO58856.1	SAMN04489713_107226	SAMN04489713_107288	Hypothetical protein; Belongs to the cytochrome P450 family.	Amino acid adenylation domain-containing protein.	0.986
SFO57530.1	SFP29197.1	SAMN04489713_107226	SAMN04489713_1132	Hypothetical protein; Belongs to the cytochrome P450 family.	Methyltransferase, FkbM family/amino acid adenylation domain-containing protein.	0.980
SFO57530.1	SFP29233.1	SAMN04489713_107226	SAMN04489713_1133	Hypothetical protein; Belongs to the cytochrome P450 family.	Amino acid adenylation domain-containing protein.	0.980
SFO57530.1	SFP29557.1	SAMN04489713_107226	SAMN04489713_11314	Hypothetical protein; Belongs to the cytochrome P450 family.	Nonribosomal peptide synthetase DhbF.	0.983
SFO57530.1	SFP31220.1	SAMN04489713_107226	SAMN04489713_11368	Hypothetical protein; Belongs to the cytochrome P450 family.	Pyochelin synthetase; Belongs to the ATP-dependent AMP-binding enzyme family.	0.980
SFO57530.1	SFP82694.1	SAMN04489713_107226	SAMN04489713_1183	Hypothetical protein; Belongs to the cytochrome P450 family.	Condensation domain-containing protein.	0.986
SFO57530.1	SFQ36534.1	SAMN04489713_107226	SAMN04489713_12899	Hypothetical protein; Belongs to the cytochrome P450 family.	Thioesterase domain-containing protein.	0.983
SFO57530.1	SFQ37819.1	SAMN04489713_107226	SAMN04489713_12922	Hypothetical protein; Belongs to the cytochrome P450 family.	8-amino-7-oxononanoate synthase.	0.984

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Network Stats

number of nodes:

11

number of edges:

27

average node degree:

4.91

avg. local clustering coefficient:

0.78

expected number of edges:

10

PPI enrichment p-value:

1.47e-05

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0009308

Amine metabolic process

4 of 36

2.14

2.1

7.55e-05

GO:0006576

Cellular biogenic amine metabolic process

3 of 23

2.21

1.45

0.0018

GO:0006596

Polyamine biosynthetic process

2 of 6

2.62

1.0

0.0152

GO:0008152

Metabolic process

11 of 5608

0.39

0.28

0.0281

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0016641

Oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor

2 of 8

2.49

0.92

0.0210

GO:0030170

Pyridoxal phosphate binding

3 of 65

1.76

0.85

0.0210

GO:0003824

Catalytic activity

11 of 4910

0.44

0.31

0.0210

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:13872

Glutamine family amino acid metabolic process, and Arginine biosynthesis

4 of 75

1.82

1.65

0.00034

CL:13868

Mixed, incl. Cellular amino acid biosynthetic process, and Alanine, aspartate and glutamate metabolism

5 of 160

1.59

1.57

0.00021

CL:13937

Aminotransferase class-III, and Pyridoxal-dependent decarboxylase conserved domain

2 of 5

2.7

1.27

0.0050

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map00330

Arginine and proline metabolism

6 of 102

1.86

3.24

1.46e-08

map00410

beta-Alanine metabolism

3 of 52

1.86

1.6

0.00051

map00360

Phenylalanine metabolism

3 of 68

1.74

1.45

0.00083

map00270

Cysteine and methionine metabolism

3 of 87

1.63

1.31

0.0014

map00350

Tyrosine metabolism

3 of 134

1.44

1.07

0.0034

(more ...)

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR004838

Aminotransferases, class-I, pyridoxal-phosphate-binding site

2 of 3

2.92

0.97

0.0178

IPR002937

Amine oxidase

2 of 8

2.49

0.93

0.0200

IPR015424

Pyridoxal phosphate-dependent transferase

3 of 54

1.84

0.9

0.0178

IPR015421

Pyridoxal phosphate-dependent transferase, major domain

3 of 54

1.84

0.9

0.0178

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