SFQ03534.1 protein (Actinomadura madurae) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

SFQ03534.1

Tight adherence protein B. (231 aa)

Predicted Functional Partners:

SFQ03569.1

0.934

SFQ03609.1

0.859

SFN95676.1

0.843

SFQ03504.1

0.824

SFP58831.1

0.790

SFN95824.1

0.765

SFN95753.1

0.721

SFN79943.1

0.721

SFQ12566.1

0.697

SFQ06781.1

0.696

Your Current Organism:

Actinomadura madurae

NCBI taxonomy Id: 1993
Other names: A. madurae, ATCC 19425, CCM 136, CCUG 32944, CECT 3043, CIP 105487, DSM 43067, IAM 14277, IFM 0585, IFO 13909, IFO 14623, IMET 9585, JCM 7436, KCTC 9192, NBRC 14623, NCIMB 13469, NCTC 5654, NRRL B-3843, Nocardia madurae, Streptomyces madurae, Streptothrix madurae, VKM Ac-809

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
SFN79943.1	SFN95676.1	SAMN04489713_10379	SAMN04489713_103545	Pilus assembly protein, ATPase of CpaF family.	Pilus assembly protein CpaE.	0.793
SFN79943.1	SFN95824.1	SAMN04489713_10379	SAMN04489713_103549	Pilus assembly protein, ATPase of CpaF family.	Tight adherence protein C.	0.912
SFN79943.1	SFP58831.1	SAMN04489713_10379	SAMN04489713_115149	Pilus assembly protein, ATPase of CpaF family.	Flp pilus assembly protein CpaB.	0.580
SFN79943.1	SFQ03504.1	SAMN04489713_10379	SAMN04489713_12125	Pilus assembly protein, ATPase of CpaF family.	Type II secretion system (T2SS), protein F.	0.798
SFN79943.1	SFQ03534.1	SAMN04489713_10379	SAMN04489713_12126	Pilus assembly protein, ATPase of CpaF family.	Tight adherence protein B.	0.721
SFN95676.1	SFN79943.1	SAMN04489713_103545	SAMN04489713_10379	Pilus assembly protein CpaE.	Pilus assembly protein, ATPase of CpaF family.	0.793
SFN95676.1	SFN95753.1	SAMN04489713_103545	SAMN04489713_103547	Pilus assembly protein CpaE.	Pilus assembly protein CpaF.	0.976
SFN95676.1	SFN95824.1	SAMN04489713_103545	SAMN04489713_103549	Pilus assembly protein CpaE.	Tight adherence protein C.	0.984
SFN95676.1	SFP58831.1	SAMN04489713_103545	SAMN04489713_115149	Pilus assembly protein CpaE.	Flp pilus assembly protein CpaB.	0.861
SFN95676.1	SFQ03504.1	SAMN04489713_103545	SAMN04489713_12125	Pilus assembly protein CpaE.	Type II secretion system (T2SS), protein F.	0.876
SFN95676.1	SFQ03534.1	SAMN04489713_103545	SAMN04489713_12126	Pilus assembly protein CpaE.	Tight adherence protein B.	0.843
SFN95676.1	SFQ03569.1	SAMN04489713_103545	SAMN04489713_12127	Pilus assembly protein CpaE.	Pilus assembly protein CpaF.	0.861
SFN95753.1	SFN95676.1	SAMN04489713_103547	SAMN04489713_103545	Pilus assembly protein CpaF.	Pilus assembly protein CpaE.	0.976
SFN95753.1	SFN95824.1	SAMN04489713_103547	SAMN04489713_103549	Pilus assembly protein CpaF.	Tight adherence protein C.	0.969
SFN95753.1	SFP58831.1	SAMN04489713_103547	SAMN04489713_115149	Pilus assembly protein CpaF.	Flp pilus assembly protein CpaB.	0.580
SFN95753.1	SFQ03504.1	SAMN04489713_103547	SAMN04489713_12125	Pilus assembly protein CpaF.	Type II secretion system (T2SS), protein F.	0.860
SFN95753.1	SFQ03534.1	SAMN04489713_103547	SAMN04489713_12126	Pilus assembly protein CpaF.	Tight adherence protein B.	0.721
SFN95824.1	SFN79943.1	SAMN04489713_103549	SAMN04489713_10379	Tight adherence protein C.	Pilus assembly protein, ATPase of CpaF family.	0.912
SFN95824.1	SFN95676.1	SAMN04489713_103549	SAMN04489713_103545	Tight adherence protein C.	Pilus assembly protein CpaE.	0.984
SFN95824.1	SFN95753.1	SAMN04489713_103549	SAMN04489713_103547	Tight adherence protein C.	Pilus assembly protein CpaF.	0.969

page 1 of 4

Network Stats

number of nodes:

11

number of edges:

55

average node degree:

10

avg. local clustering coefficient:

1

expected number of edges:

11

PPI enrichment p-value:

< 1.0e-16

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0051050

Positive regulation of transport

3 of 17

1.95

1.09

0.0078

GO:0006468

Protein phosphorylation

5 of 111

1.35

0.96

0.0052

GO:1902660

Negative regulation of glucose mediated signaling pathway

2 of 4

2.4

0.93

0.0200

GO:0000212

Meiotic spindle organization

2 of 5

2.3

0.91

0.0209

GO:0071988

Protein localization to spindle pole body

2 of 7

2.16

0.87

0.0239

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0004707

MAP kinase activity

3 of 3

2.7

2.08

0.00015

GO:0005509

Calcium ion binding

4 of 39

1.71

1.59

0.00033

GO:0004674

Protein serine/threonine kinase activity

5 of 88

1.46

1.43

0.00023

GO:0106310

Protein serine kinase activity

4 of 70

1.46

1.17

0.0017

GO:0043167

Ion binding

11 of 1403

0.6

0.51

0.00019

(more ...)

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0016459

Myosin complex

3 of 7

2.33

1.87

0.00030

GO:0005816

Spindle pole body

5 of 96

1.42

1.36

0.00030

GO:0016460

Myosin II complex

2 of 3

2.53

1.35

0.0034

GO:0044732

Mitotic spindle pole body

4 of 75

1.43

1.13

0.0020

GO:0005856

Cytoskeleton

7 of 283

1.09

1.03

0.00024

(more ...)

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:656

Myosin II complex, and Myosin I complex

3 of 6

2.4

1.78

0.00046

CL:917

Stress-activated MAPK cascade, and Activation of the AP-1 family of transcription factors

3 of 14

2.03

1.4

0.0019

CL:933

Activation of the AP-1 family of transcription factors, and Transcription factor, MADS-box

2 of 6

2.22

1.04

0.0119

CL:2383

Calmodulin-dependent protein kinase activity, and Synaptonemal structure

2 of 6

2.22

1.04

0.0119

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map04070

Phosphatidylinositol signaling system

3 of 29

1.72

1.17

0.0039

map04011

MAPK signaling pathway - yeast

3 of 79

1.28

0.66

0.0327

map04111

Cell cycle - yeast

3 of 99

1.18

0.6

0.0413

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-198753

ERK/MAPK targets

3 of 8

2.28

1.79

0.00041

MAP-450282

MAPK targets/ Nuclear events mediated by MAP kinases

3 of 10

2.18

1.73

0.00048

MAP-881907

Gastrin-CREB signalling pathway via PKC and MAPK

2 of 2

2.7

1.73

0.00069

MAP-198725

Nuclear Events (kinase and transcription factor activation)

3 of 11

2.14

1.72

0.00048

MAP-187037

Signaling by NTRK1 (TRKA)

3 of 12

2.1

1.7

0.00048

(more ...)

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0016459

Myosin complex

3 of 9

2.22

1.56

0.0011

GOCC:0016460

Myosin II complex

2 of 2

2.7

1.11

0.0096

GOCC:0071341

Medial cortical node

2 of 7

2.16

0.93

0.0182

GOCC:0005816

Spindle pole body

3 of 45

1.53

0.84

0.0171

GOCC:0032153

Cell division site

4 of 109

1.27

0.81

0.0108

(more ...)

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0106

Calcium

5 of 24

2.02

3.04

2.68e-07

KW-0723

Serine/threonine-protein kinase

4 of 29

1.84

2.05

3.63e-05

KW-0418

Kinase

6 of 171

1.25

1.36

3.63e-05

KW-0547

Nucleotide-binding

5 of 327

0.89

0.59

0.0111

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR018247

EF-Hand 1, calcium-binding site

5 of 17

2.17

3.06

5.59e-07

IPR002048

EF-hand domain

5 of 19

2.12

3.02

5.59e-07

IPR011992

EF-hand domain pair

5 of 21

2.08

2.98

5.59e-07

IPR008271

Serine/threonine-protein kinase, active site

5 of 60

1.62

1.82

4.22e-05

IPR000719

Protein kinase domain

5 of 77

1.51

1.58

0.00011

(more ...)

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00054

EF-hand, calcium binding motif

5 of 10

2.4

4.09

7.78e-09

SM00220

Serine/Threonine protein kinases, catalytic domain

3 of 34

1.65

1.08

0.0054

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