STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
caiBCrotonobetainyl-CoA:carnitine CoA-transferase; Catalyzes the reversible transfer of the CoA moiety from gamma-butyrobetainyl-CoA to L-carnitine to generate L-carnitinyl-CoA and gamma-butyrobetaine. Is also able to catalyze the reversible transfer of the CoA moiety from gamma-butyrobetainyl-CoA or L- carnitinyl-CoA to crotonobetaine to generate crotonobetainyl-CoA. Belongs to the CoA-transferase III family. CaiB subfamily. (405 aa)    
Predicted Functional Partners:
caiD
Carnitinyl-CoA dehydratase; Catalyzes the reversible dehydration of L-carnitinyl-CoA to crotonobetainyl-CoA.
 
 
 0.978
caiC
Probable crotonobetaine/carnitine-CoA ligase; Catalyzes the transfer of CoA to carnitine, generating the initial carnitinyl-CoA needed for the CaiB reaction cycle. Also has activity toward crotonobetaine and gamma-butyrobetaine.
 
  
 0.974
caiA
Crotonobetainyl-CoA dehydrogenase; Catalyzes the reduction of crotonobetainyl-CoA to gamma- butyrobetainyl-CoA; Belongs to the acyl-CoA dehydrogenase family.
 
 
 0.973
caiT
Probable carnitine transporter; Catalyzes the exchange of L-carnitine for gamma-butyrobetaine and related betaines.
 
   
 0.924
caiE
Carnitine operon protein caiE; Overproduction of CaiE stimulates the activity of CaiB and CaiD; Belongs to the transferase hexapeptide repeat family.
     
 0.908
ydiO
Hypothetical protein ydiO; Escherichia coli K-12 ortholog: b1695; Escherichia coli O157:H7 ortholog: z2723; Belongs to the acyl-CoA dehydrogenase family.
 
 
 0.733
fixA
FixA protein; Required for anaerobic carnitine reduction. May bring reductant to CaiA.
 
 
 
 0.728
c2464
Putative acyl-coa dehydrogenase; Residues 3 to 335 of 342 are 35.02 pct identical to residues 35 to 368 of 382 from GenPept.129 : >gb|AAD40109.1|AF155831_3 (AF155831) unknown [Bacillus cereus].
 
 
 0.720
leuD
3-isopropylmalate dehydratase small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 1 subfamily.
     
 0.718
thrB
Homoserine kinase; Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate; Belongs to the GHMP kinase family. Homoserine kinase subfamily.
      
 0.709
Your Current Organism:
Escherichia coli CFT073
NCBI taxonomy Id: 199310
Other names: E. coli CFT073, Escherichia coli str. CFT073, Escherichia coli strain CFT073
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