STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ampDAmpD protein; Escherichia coli K-12 ortholog: b0110; Escherichia coli O157:H7 ortholog: z0120. (183 aa)    
Predicted Functional Partners:
ampE
AmpE protein; Escherichia coli K-12 ortholog: b0111; Escherichia coli O157:H7 ortholog: z0121.
  
  
 0.966
nagZ
Beta-hexosaminidase; Plays a role in peptidoglycan recycling by cleaving the terminal beta-1,4-linked N-acetylglucosamine (GlcNAc) from peptide- linked peptidoglycan fragments, giving rise to free GlcNAc, anhydro-N- acetylmuramic acid and anhydro-N-acetylmuramic acid-linked peptides.
 
  
 0.944
ampG
AmpG protein; Escherichia coli K-12 ortholog: b0433; Escherichia coli O157:H7 ortholog: z0536.
     
 0.907
ldcA
Muramoyltetrapeptide carboxypeptidase; Releases the terminal D-alanine residue from the cytoplasmic tetrapeptide recycling product L-Ala-gamma-D-Glu-meso-Dap-D-Ala. Can also cleave D-Ala from murein derivatives containing the tetrapeptide, i.e. MurNAc-tetrapeptide, UDP-MurNAc-tetrapeptide, GlcNAc-MurNAc- tetrapeptide, and GlcNAc-anhMurNAc-tetrapeptide. Does not act on murein sacculi or cross-linked muropeptides. The tripeptides produced by the LcdA reaction can then be reused as peptidoglycan building blocks; LcdA is thereby involved in murein recycling (By similarity); Belongs to the [...]
     
 0.833
dacB
Penicillin-binding protein 4 precursor; PBP-4; Escherichia coli K-12 ortholog: b3182; Escherichia coli O157:H7 ortholog: z4544; bifunctional; D-alanyl-D-alanine carboxypeptidase; D-alanyl-D-alanine-endopeptidase.
      
 0.818
yjfG
UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl- meso-diaminopimelate ligase; Reutilizes the intact tripeptide L-alanyl-gamma-D-glutamyl- meso-diaminopimelate by linking it to UDP-N-acetylmuramate. Belongs to the MurCDEF family. Mpl subfamily.
  
   
 0.756
ydhH
Hypothetical protein ydhH; Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling; Belongs to the anhydro-N-acetylmuramic acid kinase family.
  
   
 0.697
nadC
Nicotinate-nucleotide pyrophosphorylase (carboxylating); Escherichia coli K-12 ortholog: b0109; Escherichia coli O157:H7 ortholog: z0119; Belongs to the NadC/ModD family.
  
  
 0.631
c2452
Hypothetical protein; Residues 41 to 499 of 504 are 27.77 pct identical to residues 41 to 494 of 498 from GenPept.129 : >dbj|BAB58603.1| (AP003365) hypothetical protein [Staphylococcus aureus subsp. aureus Mu50].
      
 0.622
ampC
Beta-lactamase precursor; Escherichia coli K-12 ortholog: b4150; Escherichia coli O157:H7 ortholog: z5757.
      
 0.622
Your Current Organism:
Escherichia coli CFT073
NCBI taxonomy Id: 199310
Other names: E. coli CFT073, Escherichia coli str. CFT073, Escherichia coli strain CFT073
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