STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
cusAPutative cation efflux system protein cusA; Part of a cation efflux system that mediates resistance to copper and silver; Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family. (1047 aa)    
Predicted Functional Partners:
cusC
Probable outer membrane lipoprotein cusC precursor; Forms pores that allow passive diffusion of cations across the outer membrane. Part of a cation efflux system that mediates resistance to copper and silver (By similarity); Belongs to the outer membrane factor (OMF) (TC 1.B.17) family.
 
 0.999
cusB
Putative copper efflux system protein cusB precursor; Part of a cation efflux system that mediates resistance to copper and silver.
 0.999
cusX
Hypothetical protein cusX precursor; Part of a cation efflux system that mediates resistance to copper and silver. Binds one copper per polypeptide (By similarity).
 
 
 0.993
cusS
Sensor kinase cusS; Member of the two-component regulatory system CusS/CusR involved in response to copper and silver. Acts as a copper/silver ion sensor. Activates CusR by phosphorylation.
 
   
 0.931
cusR
Transcriptional Regulatory protein cusR; Member of the two-component regulatory system CusS/CusR involved in response to copper and silver.
 
  
 0.927
yacK
Blue copper oxidase cueO precursor; Copper efflux oxidase; Escherichia coli K-12 ortholog: b0123; Escherichia coli O157:H7 ortholog: z0133.
     
 0.830
acrA
Acriflavine resistance protein A precursor; Escherichia coli K-12 ortholog: b0463; Escherichia coli O157:H7 ortholog: z0578; Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.
  
 
 0.788
ybbI
Transcriptional regulator cueR; Regulates the transcription of the copA and cueO genes. It detects cytoplasmic copper stress and activates transcription in response to increasing copper concentrations (By similarity).
  
  
 0.698
macA
Macrolide-specific efflux protein macA precursor; Escherichia coli K-12 ortholog: b0878; Escherichia coli O157:H7 ortholog: z1115; Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.
  
 
 0.680
ybaR
Copper-transporting P-type ATPase; Escherichia coli K-12 ortholog: b0484; Escherichia coli O157:H7 ortholog: z0604.
     
 0.596
Your Current Organism:
Escherichia coli CFT073
NCBI taxonomy Id: 199310
Other names: E. coli CFT073, Escherichia coli str. CFT073, Escherichia coli strain CFT073
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.