node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
araH | ycaJ | c2312 | c1029 | High-affinity L-arabinose transport system; Escherichia coli K-12 ortholog: b1899; Escherichia coli O157:H7 ortholog: z2951; Belongs to the binding-protein-dependent transport system permease family. | Hypothetical protein ycaJ; DNA-dependent ATPase that plays important roles in cellular responses to stalled DNA replication processes. | 0.681 |
c4223 | recQ | c4223 | c4744 | Putative conserved protein; Residues 6 to 340 of 699 are 37.53 pct identical to residues 14 to 331 of 610 from MG1655 : b3822. | ATP-dependent DNA helicase recQ; Escherichia coli K-12 ortholog: b3822; Escherichia coli O157:H7 ortholog: z5343. | 0.926 |
c4223 | ycaJ | c4223 | c1029 | Putative conserved protein; Residues 6 to 340 of 699 are 37.53 pct identical to residues 14 to 331 of 610 from MG1655 : b3822. | Hypothetical protein ycaJ; DNA-dependent ATPase that plays important roles in cellular responses to stalled DNA replication processes. | 0.486 |
dinP | recQ | c0379 | c4744 | DNA polymerase IV; Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII (By similarity). | ATP-dependent DNA helicase recQ; Escherichia coli K-12 ortholog: b3822; Escherichia coli O157:H7 ortholog: z5343. | 0.453 |
dinP | ycaJ | c0379 | c1029 | DNA polymerase IV; Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII (By similarity). | Hypothetical protein ycaJ; DNA-dependent ATPase that plays important roles in cellular responses to stalled DNA replication processes. | 0.440 |
ftsK | lolA | c1027 | c1028 | Cell division protein ftsK; Essential cell division protein that coordinates cell division and chromosome segregation. The N-terminus is involved in assembly of the cell-division machinery. The C-terminus functions as a DNA motor that moves dsDNA in an ATP-dependent manner towards the dif recombination site, which is located within the replication terminus region. Translocation stops specifically at Xer-dif sites, where FtsK interacts with the Xer recombinase, allowing activation of chromosome unlinking by recombination. FtsK orienting polar sequences (KOPS) guide the direction of DNA [...] | Outer-membrane lipoproteins carrier protein precursor; Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane) (By similarity). | 0.737 |
ftsK | serS | c1027 | c1030 | Cell division protein ftsK; Essential cell division protein that coordinates cell division and chromosome segregation. The N-terminus is involved in assembly of the cell-division machinery. The C-terminus functions as a DNA motor that moves dsDNA in an ATP-dependent manner towards the dif recombination site, which is located within the replication terminus region. Translocation stops specifically at Xer-dif sites, where FtsK interacts with the Xer recombinase, allowing activation of chromosome unlinking by recombination. FtsK orienting polar sequences (KOPS) guide the direction of DNA [...] | Seryl-tRNA synthetase; Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L- seryl-tRNA(Sec), which will be further converted into selenocysteinyl- tRNA(Sec). | 0.426 |
ftsK | ycaJ | c1027 | c1029 | Cell division protein ftsK; Essential cell division protein that coordinates cell division and chromosome segregation. The N-terminus is involved in assembly of the cell-division machinery. The C-terminus functions as a DNA motor that moves dsDNA in an ATP-dependent manner towards the dif recombination site, which is located within the replication terminus region. Translocation stops specifically at Xer-dif sites, where FtsK interacts with the Xer recombinase, allowing activation of chromosome unlinking by recombination. FtsK orienting polar sequences (KOPS) guide the direction of DNA [...] | Hypothetical protein ycaJ; DNA-dependent ATPase that plays important roles in cellular responses to stalled DNA replication processes. | 0.618 |
lolA | ftsK | c1028 | c1027 | Outer-membrane lipoproteins carrier protein precursor; Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane) (By similarity). | Cell division protein ftsK; Essential cell division protein that coordinates cell division and chromosome segregation. The N-terminus is involved in assembly of the cell-division machinery. The C-terminus functions as a DNA motor that moves dsDNA in an ATP-dependent manner towards the dif recombination site, which is located within the replication terminus region. Translocation stops specifically at Xer-dif sites, where FtsK interacts with the Xer recombinase, allowing activation of chromosome unlinking by recombination. FtsK orienting polar sequences (KOPS) guide the direction of DNA [...] | 0.737 |
lolA | serS | c1028 | c1030 | Outer-membrane lipoproteins carrier protein precursor; Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane) (By similarity). | Seryl-tRNA synthetase; Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L- seryl-tRNA(Sec), which will be further converted into selenocysteinyl- tRNA(Sec). | 0.714 |
lolA | ycaJ | c1028 | c1029 | Outer-membrane lipoproteins carrier protein precursor; Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane) (By similarity). | Hypothetical protein ycaJ; DNA-dependent ATPase that plays important roles in cellular responses to stalled DNA replication processes. | 0.812 |
ogt | ycaJ | c1808 | c1029 | Methylated-DNA--protein-cysteine methyltransferase; Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction: the enzyme is irreversibly inactivated. | Hypothetical protein ycaJ; DNA-dependent ATPase that plays important roles in cellular responses to stalled DNA replication processes. | 0.452 |
recQ | c4223 | c4744 | c4223 | ATP-dependent DNA helicase recQ; Escherichia coli K-12 ortholog: b3822; Escherichia coli O157:H7 ortholog: z5343. | Putative conserved protein; Residues 6 to 340 of 699 are 37.53 pct identical to residues 14 to 331 of 610 from MG1655 : b3822. | 0.926 |
recQ | dinP | c4744 | c0379 | ATP-dependent DNA helicase recQ; Escherichia coli K-12 ortholog: b3822; Escherichia coli O157:H7 ortholog: z5343. | DNA polymerase IV; Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII (By similarity). | 0.453 |
recQ | ycaJ | c4744 | c1029 | ATP-dependent DNA helicase recQ; Escherichia coli K-12 ortholog: b3822; Escherichia coli O157:H7 ortholog: z5343. | Hypothetical protein ycaJ; DNA-dependent ATPase that plays important roles in cellular responses to stalled DNA replication processes. | 0.525 |
rpsD | ycaJ | c4057 | c1029 | 30S ribosomal protein S4; One of two assembly initiator proteins for the 30S subunit, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit. Protein S4 is also a translational repressor protein, it controls the translation of the alpha-operon (which codes for S13, S11, S4, RNA polymerase alpha subunit, and L17) by binding to its mRNA. | Hypothetical protein ycaJ; DNA-dependent ATPase that plays important roles in cellular responses to stalled DNA replication processes. | 0.722 |
serS | ftsK | c1030 | c1027 | Seryl-tRNA synthetase; Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L- seryl-tRNA(Sec), which will be further converted into selenocysteinyl- tRNA(Sec). | Cell division protein ftsK; Essential cell division protein that coordinates cell division and chromosome segregation. The N-terminus is involved in assembly of the cell-division machinery. The C-terminus functions as a DNA motor that moves dsDNA in an ATP-dependent manner towards the dif recombination site, which is located within the replication terminus region. Translocation stops specifically at Xer-dif sites, where FtsK interacts with the Xer recombinase, allowing activation of chromosome unlinking by recombination. FtsK orienting polar sequences (KOPS) guide the direction of DNA [...] | 0.426 |
serS | lolA | c1030 | c1028 | Seryl-tRNA synthetase; Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L- seryl-tRNA(Sec), which will be further converted into selenocysteinyl- tRNA(Sec). | Outer-membrane lipoproteins carrier protein precursor; Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane) (By similarity). | 0.714 |
serS | ycaJ | c1030 | c1029 | Seryl-tRNA synthetase; Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L- seryl-tRNA(Sec), which will be further converted into selenocysteinyl- tRNA(Sec). | Hypothetical protein ycaJ; DNA-dependent ATPase that plays important roles in cellular responses to stalled DNA replication processes. | 0.597 |
ycaJ | araH | c1029 | c2312 | Hypothetical protein ycaJ; DNA-dependent ATPase that plays important roles in cellular responses to stalled DNA replication processes. | High-affinity L-arabinose transport system; Escherichia coli K-12 ortholog: b1899; Escherichia coli O157:H7 ortholog: z2951; Belongs to the binding-protein-dependent transport system permease family. | 0.681 |