STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
c1205Hypothetical protein; Residues 678 to 908 of 908 are 24.05 pct identical to residues 2464 to 2674 of 3535 from GenPept.129 : >gb|AAG03431.1|AE004443_9 (AE004443) probable hemagglutinin [Pseudomonas aeruginosa]. (908 aa)    
Predicted Functional Partners:
c1206
Hypothetical protein; Residues 8 to 375 of 410 are 24.61 pct identical to residues 1490 to 1839 of 2535 from GenPept.129 : >emb|CAC91295.1| (AJ414152) putative hemolysin [Yersinia pestis].
     0.961
c1207
Hypothetical protein; Residues 13 to 409 of 537 are 50.72 pct identical to residues 1970 to 2381 of 2535 from GenPept.129 : >emb|CAC91295.1| (AJ414152) putative hemolysin [Yersinia pestis].
     0.947
hipB
Protein hipB; Antitoxin component of a type II type II toxin-antitoxin (TA) system. Neutralizes the toxic effect of cognate toxin HipA. Represses the hipBA operon promoter (By similarity).
  
     0.505
hipA
Protein hipA; Toxic component of a type II toxin-antitoxin (TA) system. Phosphorylates Glu-tRNA-ligase (GltX, on 'Ser-239') in vivo. Phosphorylation of GltX prevents it from being charged, leading to an increase in uncharged tRNA(Glu). This induces amino acid starvation and the stringent response via RelA/SpoT and increased ppGpp levels, which inhibits replication, transcription, translation and cell wall synthesis, reducing growth and leading to multidrug resistance and persistence. Low level expression of HipA induces dormancy and depending on the protein level, can be toxic enough t [...]
  
     0.501
c4518
Conserved hypothetical protein; Residues 30 to 145 of 145 are 97.41 pct identical to residues 1 to 116 of 348 from GenPept.129 : >gb|AAG55755.1|AE005312_1 (AE005312) Z1640 gene product [Escherichia coli O157:H7 EDL933].
 
 
 0.480
Your Current Organism:
Escherichia coli CFT073
NCBI taxonomy Id: 199310
Other names: E. coli CFT073, Escherichia coli str. CFT073, Escherichia coli strain CFT073
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.