node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
fdhF | selA | c5625 | c4412 | Formate dehydrogenase H; Escherichia coli K-12 ortholog: b4079; Escherichia coli O157:H7 ortholog: z5678; Belongs to the prokaryotic molybdopterin-containing oxidoreductase family. | L-seryl-tRNA(Sec) selenium transferase; Converts seryl-tRNA(Sec) to selenocysteinyl-tRNA(Sec) required for selenoprotein biosynthesis; Belongs to the SelA family. | 0.846 |
fdhF | selB | c5625 | c4411 | Formate dehydrogenase H; Escherichia coli K-12 ortholog: b4079; Escherichia coli O157:H7 ortholog: z5678; Belongs to the prokaryotic molybdopterin-containing oxidoreductase family. | Selenocysteine-specific elongation factor; SelB translation factor; Escherichia coli K-12 ortholog: b3590; Escherichia coli O157:H7 ortholog: z5011. | 0.850 |
fdhF | selD | c5625 | c2167 | Formate dehydrogenase H; Escherichia coli K-12 ortholog: b4079; Escherichia coli O157:H7 ortholog: z5678; Belongs to the prokaryotic molybdopterin-containing oxidoreductase family. | Selenide,water dikinase; Synthesizes selenophosphate from selenide and ATP. | 0.833 |
selA | fdhF | c4412 | c5625 | L-seryl-tRNA(Sec) selenium transferase; Converts seryl-tRNA(Sec) to selenocysteinyl-tRNA(Sec) required for selenoprotein biosynthesis; Belongs to the SelA family. | Formate dehydrogenase H; Escherichia coli K-12 ortholog: b4079; Escherichia coli O157:H7 ortholog: z5678; Belongs to the prokaryotic molybdopterin-containing oxidoreductase family. | 0.846 |
selA | selB | c4412 | c4411 | L-seryl-tRNA(Sec) selenium transferase; Converts seryl-tRNA(Sec) to selenocysteinyl-tRNA(Sec) required for selenoprotein biosynthesis; Belongs to the SelA family. | Selenocysteine-specific elongation factor; SelB translation factor; Escherichia coli K-12 ortholog: b3590; Escherichia coli O157:H7 ortholog: z5011. | 0.996 |
selA | selD | c4412 | c2167 | L-seryl-tRNA(Sec) selenium transferase; Converts seryl-tRNA(Sec) to selenocysteinyl-tRNA(Sec) required for selenoprotein biosynthesis; Belongs to the SelA family. | Selenide,water dikinase; Synthesizes selenophosphate from selenide and ATP. | 0.997 |
selA | trxB | c4412 | c1025 | L-seryl-tRNA(Sec) selenium transferase; Converts seryl-tRNA(Sec) to selenocysteinyl-tRNA(Sec) required for selenoprotein biosynthesis; Belongs to the SelA family. | Thioredoxin reductase; Escherichia coli K-12 ortholog: b0888; Escherichia coli O157:H7 ortholog: z1232. | 0.407 |
selA | ybbB | c4412 | c0618 | L-seryl-tRNA(Sec) selenium transferase; Converts seryl-tRNA(Sec) to selenocysteinyl-tRNA(Sec) required for selenoprotein biosynthesis; Belongs to the SelA family. | Hypothetical protein ybbB; Involved in the post-transcriptional modification of the uridine at the wobble position (U34) of tRNA(Lys), tRNA(Glu) and tRNA(Gln). Catalyzes the conversion of 2-thiouridine (S2U-RNA) to 2- selenouridine (Se2U-RNA). Acts in a two-step process involving geranylation of 2-thiouridine (S2U) to S-geranyl-2-thiouridine (geS2U) and subsequent selenation of the latter derivative to 2-selenouridine (Se2U) in the tRNA chain. | 0.752 |
selA | yqeB | c4412 | c3453 | L-seryl-tRNA(Sec) selenium transferase; Converts seryl-tRNA(Sec) to selenocysteinyl-tRNA(Sec) required for selenoprotein biosynthesis; Belongs to the SelA family. | Hypothetical protein yqeB; Escherichia coli K-12 ortholog: b2875; Escherichia coli O157:H7 ortholog: z4214. | 0.611 |
selB | fdhF | c4411 | c5625 | Selenocysteine-specific elongation factor; SelB translation factor; Escherichia coli K-12 ortholog: b3590; Escherichia coli O157:H7 ortholog: z5011. | Formate dehydrogenase H; Escherichia coli K-12 ortholog: b4079; Escherichia coli O157:H7 ortholog: z5678; Belongs to the prokaryotic molybdopterin-containing oxidoreductase family. | 0.850 |
selB | selA | c4411 | c4412 | Selenocysteine-specific elongation factor; SelB translation factor; Escherichia coli K-12 ortholog: b3590; Escherichia coli O157:H7 ortholog: z5011. | L-seryl-tRNA(Sec) selenium transferase; Converts seryl-tRNA(Sec) to selenocysteinyl-tRNA(Sec) required for selenoprotein biosynthesis; Belongs to the SelA family. | 0.996 |
selB | selD | c4411 | c2167 | Selenocysteine-specific elongation factor; SelB translation factor; Escherichia coli K-12 ortholog: b3590; Escherichia coli O157:H7 ortholog: z5011. | Selenide,water dikinase; Synthesizes selenophosphate from selenide and ATP. | 0.975 |
selB | ybbB | c4411 | c0618 | Selenocysteine-specific elongation factor; SelB translation factor; Escherichia coli K-12 ortholog: b3590; Escherichia coli O157:H7 ortholog: z5011. | Hypothetical protein ybbB; Involved in the post-transcriptional modification of the uridine at the wobble position (U34) of tRNA(Lys), tRNA(Glu) and tRNA(Gln). Catalyzes the conversion of 2-thiouridine (S2U-RNA) to 2- selenouridine (Se2U-RNA). Acts in a two-step process involving geranylation of 2-thiouridine (S2U) to S-geranyl-2-thiouridine (geS2U) and subsequent selenation of the latter derivative to 2-selenouridine (Se2U) in the tRNA chain. | 0.835 |
selB | yqeB | c4411 | c3453 | Selenocysteine-specific elongation factor; SelB translation factor; Escherichia coli K-12 ortholog: b3590; Escherichia coli O157:H7 ortholog: z5011. | Hypothetical protein yqeB; Escherichia coli K-12 ortholog: b2875; Escherichia coli O157:H7 ortholog: z4214. | 0.647 |
selD | fdhF | c2167 | c5625 | Selenide,water dikinase; Synthesizes selenophosphate from selenide and ATP. | Formate dehydrogenase H; Escherichia coli K-12 ortholog: b4079; Escherichia coli O157:H7 ortholog: z5678; Belongs to the prokaryotic molybdopterin-containing oxidoreductase family. | 0.833 |
selD | selA | c2167 | c4412 | Selenide,water dikinase; Synthesizes selenophosphate from selenide and ATP. | L-seryl-tRNA(Sec) selenium transferase; Converts seryl-tRNA(Sec) to selenocysteinyl-tRNA(Sec) required for selenoprotein biosynthesis; Belongs to the SelA family. | 0.997 |
selD | selB | c2167 | c4411 | Selenide,water dikinase; Synthesizes selenophosphate from selenide and ATP. | Selenocysteine-specific elongation factor; SelB translation factor; Escherichia coli K-12 ortholog: b3590; Escherichia coli O157:H7 ortholog: z5011. | 0.975 |
selD | sufS | c2167 | c2075 | Selenide,water dikinase; Synthesizes selenophosphate from selenide and ATP. | Selenocysteine lyase; Cysteine desulfurases mobilize the sulfur from L-cysteine to yield L-alanine, an essential step in sulfur metabolism for biosynthesis of a variety of sulfur-containing biomolecules. Component of the suf operon, which is activated and required under specific conditions such as oxidative stress and iron limitation. Acts as a potent selenocysteine lyase in vitro, that mobilizes selenium from L- selenocysteine. Selenocysteine lyase activity is however unsure in vivo. | 0.933 |
selD | topB | c2167 | c2166 | Selenide,water dikinase; Synthesizes selenophosphate from selenide and ATP. | DNA topoisomerase III; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA su [...] | 0.802 |
selD | trxB | c2167 | c1025 | Selenide,water dikinase; Synthesizes selenophosphate from selenide and ATP. | Thioredoxin reductase; Escherichia coli K-12 ortholog: b0888; Escherichia coli O157:H7 ortholog: z1232. | 0.916 |