STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
fliDFlagellar hook-associated protein 2; Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end. (468 aa)    
Predicted Functional Partners:
fliS
Flagellar protein fliS; Escherichia coli K-12 ortholog: b1925; Escherichia coli O157:H7 ortholog: z3015.
 
 
 0.999
flgK
Flagellar hook-associated protein 1; HAP1; Escherichia coli K-12 ortholog: b1082; Escherichia coli O157:H7 ortholog: z1720.
 
  
 0.997
flgL
Flagellar hook-associated protein 3; HAP3; Escherichia coli K-12 ortholog: b1083; Escherichia coli O157:H7 ortholog: z1721.
 
 
 0.997
fliC
Flagellin; Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella.
 
 
 0.997
fliT
Flagellar protein fliT; Dual-function protein that regulates the transcription of class 2 flagellar operons and that also acts as an export chaperone for the filament-capping protein FliD. As a transcriptional regulator, acts as an anti-FlhDC factor; it directly binds FlhC, thus inhibiting the binding of the FlhC/FlhD complex to class 2 promoters, resulting in decreased expression of class 2 flagellar operons. As a chaperone, effects FliD transition to the membrane by preventing its premature polymerization, and by directing it to the export apparatus.
 
 
 0.994
flgB
Flagellar basal-body rod protein flgB; Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body (By similarity).
 
  
 0.992
flgD
Basal-body rod modification protein flgD; Required for flagellar hook formation. May act as a scaffolding protein.
 
  
 0.990
flgE
Flagellar hook protein flgE; Escherichia coli K-12 ortholog: b1076; Escherichia coli O157:H7 ortholog: z1714.
 
  
 0.990
fliF
Flagellar M-ring protein; The M ring may be actively involved in energy transduction. Belongs to the FliF family.
 
  
 0.987
fliI
Flagellum-specific ATP synthase; Escherichia coli K-12 ortholog: b1941; Escherichia coli O157:H7 ortholog: z3031.
 
  
 0.986
Your Current Organism:
Escherichia coli CFT073
NCBI taxonomy Id: 199310
Other names: E. coli CFT073, Escherichia coli str. CFT073, Escherichia coli strain CFT073
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