node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
aroC | hisB | c2875 | c2549 | Chorismate synthase; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system. | Histidine biosynthesis bifunctional protein hisB; Escherichia coli K-12 ortholog: b2022; Escherichia coli O157:H7 ortholog: z3184; bifunctional; Histidinol-phosphatase; Imidazoleglycerol-phosphate dehydratase; In the C-terminal section; belongs to the imidazoleglycerol-phosphate dehydratase family. | 0.469 |
aroC | hisC | c2875 | c2548 | Chorismate synthase; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system. | Histidinol-phosphate aminotransferase; Escherichia coli K-12 ortholog: b2021; Escherichia coli O157:H7 ortholog: z3183; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. | 0.784 |
aroC | hisD | c2875 | c2547 | Chorismate synthase; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system. | Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. | 0.887 |
aroC | purE | c2875 | c0637 | Chorismate synthase; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system. | Phosphoribosylaminoimidazole carboxylase catalytic subunit; Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR). | 0.833 |
aroC | thrA | c2875 | c0003 | Chorismate synthase; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system. | Bifunctional; Escherichia coli K-12 ortholog: b0002; Escherichia coli O157:H7 ortholog: z0002; bifunctional; Homoserine dehydrogenase I; In the C-terminal section; belongs to the homoserine dehydrogenase family. | 0.888 |
hisA | hisB | c2551 | c2549 | 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase; Escherichia coli K-12 ortholog: b2024; Escherichia coli O157:H7 ortholog: z3186; Belongs to the HisA/HisF family. | Histidine biosynthesis bifunctional protein hisB; Escherichia coli K-12 ortholog: b2022; Escherichia coli O157:H7 ortholog: z3184; bifunctional; Histidinol-phosphatase; Imidazoleglycerol-phosphate dehydratase; In the C-terminal section; belongs to the imidazoleglycerol-phosphate dehydratase family. | 0.999 |
hisA | hisC | c2551 | c2548 | 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase; Escherichia coli K-12 ortholog: b2024; Escherichia coli O157:H7 ortholog: z3186; Belongs to the HisA/HisF family. | Histidinol-phosphate aminotransferase; Escherichia coli K-12 ortholog: b2021; Escherichia coli O157:H7 ortholog: z3183; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. | 0.999 |
hisA | hisD | c2551 | c2547 | 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase; Escherichia coli K-12 ortholog: b2024; Escherichia coli O157:H7 ortholog: z3186; Belongs to the HisA/HisF family. | Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. | 0.997 |
hisA | hisF | c2551 | c2552 | 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase; Escherichia coli K-12 ortholog: b2024; Escherichia coli O157:H7 ortholog: z3186; Belongs to the HisA/HisF family. | Imidazole glycerol phosphate synthase subunit hisF; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. | 0.999 |
hisA | hisG | c2551 | c2546 | 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase; Escherichia coli K-12 ortholog: b2024; Escherichia coli O157:H7 ortholog: z3186; Belongs to the HisA/HisF family. | ATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity). | 0.998 |
hisA | hisH | c2551 | c2550 | 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase; Escherichia coli K-12 ortholog: b2024; Escherichia coli O157:H7 ortholog: z3186; Belongs to the HisA/HisF family. | Imidazole glycerol phosphate synthase subunit hisH; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF (By similarity). | 0.999 |
hisA | hisI | c2551 | c2553 | 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase; Escherichia coli K-12 ortholog: b2024; Escherichia coli O157:H7 ortholog: z3186; Belongs to the HisA/HisF family. | Histidine biosynthesis bifunctional protein hisIE; Escherichia coli K-12 ortholog: b2026; Escherichia coli O157:H7 ortholog: z3188; bifunctional; Phosphoribosyl-AMP cyclohydrolase; Phosphoribosyl-ATP pyrophosphatase; In the C-terminal section; belongs to the PRA-PH family. | 0.999 |
hisA | thrA | c2551 | c0003 | 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase; Escherichia coli K-12 ortholog: b2024; Escherichia coli O157:H7 ortholog: z3186; Belongs to the HisA/HisF family. | Bifunctional; Escherichia coli K-12 ortholog: b0002; Escherichia coli O157:H7 ortholog: z0002; bifunctional; Homoserine dehydrogenase I; In the C-terminal section; belongs to the homoserine dehydrogenase family. | 0.565 |
hisB | aroC | c2549 | c2875 | Histidine biosynthesis bifunctional protein hisB; Escherichia coli K-12 ortholog: b2022; Escherichia coli O157:H7 ortholog: z3184; bifunctional; Histidinol-phosphatase; Imidazoleglycerol-phosphate dehydratase; In the C-terminal section; belongs to the imidazoleglycerol-phosphate dehydratase family. | Chorismate synthase; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system. | 0.469 |
hisB | hisA | c2549 | c2551 | Histidine biosynthesis bifunctional protein hisB; Escherichia coli K-12 ortholog: b2022; Escherichia coli O157:H7 ortholog: z3184; bifunctional; Histidinol-phosphatase; Imidazoleglycerol-phosphate dehydratase; In the C-terminal section; belongs to the imidazoleglycerol-phosphate dehydratase family. | 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase; Escherichia coli K-12 ortholog: b2024; Escherichia coli O157:H7 ortholog: z3186; Belongs to the HisA/HisF family. | 0.999 |
hisB | hisC | c2549 | c2548 | Histidine biosynthesis bifunctional protein hisB; Escherichia coli K-12 ortholog: b2022; Escherichia coli O157:H7 ortholog: z3184; bifunctional; Histidinol-phosphatase; Imidazoleglycerol-phosphate dehydratase; In the C-terminal section; belongs to the imidazoleglycerol-phosphate dehydratase family. | Histidinol-phosphate aminotransferase; Escherichia coli K-12 ortholog: b2021; Escherichia coli O157:H7 ortholog: z3183; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. | 0.999 |
hisB | hisD | c2549 | c2547 | Histidine biosynthesis bifunctional protein hisB; Escherichia coli K-12 ortholog: b2022; Escherichia coli O157:H7 ortholog: z3184; bifunctional; Histidinol-phosphatase; Imidazoleglycerol-phosphate dehydratase; In the C-terminal section; belongs to the imidazoleglycerol-phosphate dehydratase family. | Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. | 0.999 |
hisB | hisF | c2549 | c2552 | Histidine biosynthesis bifunctional protein hisB; Escherichia coli K-12 ortholog: b2022; Escherichia coli O157:H7 ortholog: z3184; bifunctional; Histidinol-phosphatase; Imidazoleglycerol-phosphate dehydratase; In the C-terminal section; belongs to the imidazoleglycerol-phosphate dehydratase family. | Imidazole glycerol phosphate synthase subunit hisF; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. | 0.999 |
hisB | hisG | c2549 | c2546 | Histidine biosynthesis bifunctional protein hisB; Escherichia coli K-12 ortholog: b2022; Escherichia coli O157:H7 ortholog: z3184; bifunctional; Histidinol-phosphatase; Imidazoleglycerol-phosphate dehydratase; In the C-terminal section; belongs to the imidazoleglycerol-phosphate dehydratase family. | ATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity). | 0.999 |
hisB | hisH | c2549 | c2550 | Histidine biosynthesis bifunctional protein hisB; Escherichia coli K-12 ortholog: b2022; Escherichia coli O157:H7 ortholog: z3184; bifunctional; Histidinol-phosphatase; Imidazoleglycerol-phosphate dehydratase; In the C-terminal section; belongs to the imidazoleglycerol-phosphate dehydratase family. | Imidazole glycerol phosphate synthase subunit hisH; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF (By similarity). | 0.999 |