STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ligDNA ligase; DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double- stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA. (671 aa)    
Predicted Functional Partners:
yicF
Hypothetical DNA ligase-like protein yicF; Catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. Belongs to the NAD-dependent DNA ligase family. LigB subfamily.
  
  
0.928
leuS
Leucyl-tRNA synthetase; Escherichia coli K-12 ortholog: b0642; Escherichia coli O157:H7 ortholog: z0789; Belongs to the class-I aminoacyl-tRNA synthetase family.
  
 
 
 0.852
c2944
Conserved hypothetical protein; Escherichia coli O157:H7 ortholog: z3676.
       0.802
sun
SUN protein; Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA.
  
  
 0.761
ydbK
Probable pyruvate-flavodoxin oxidoreductase; Escherichia coli K-12 ortholog: b1378; Escherichia coli O157:H7 ortholog: z2332.
   
   0.678
uvrD
DNA helicase II; Escherichia coli K-12 ortholog: b3813; Escherichia coli O157:H7 ortholog: z5330.
 
  
 0.668
rep
ATP-dependent DNA helicase rep; Rep helicase is a single-stranded DNA-dependent ATPase involved in DNA replication; it can initiate unwinding at a nick in the DNA. It binds to the single-stranded DNA and acts in a progressive fashion along the DNA in the 3' to 5' direction.
 
  
 0.630
topA
DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supe [...]
 
 
 
 0.625
cmk
Cytidylate kinase; Escherichia coli K-12 ortholog: b0910; Escherichia coli O157:H7 ortholog: z1256.
 
  
 0.620
zipA
Cell division protein zipA; Essential cell division protein that stabilizes the FtsZ protofilaments by cross-linking them and that serves as a cytoplasmic membrane anchor for the Z ring. Also required for the recruitment to the septal ring of downstream cell division proteins.
       0.600
Your Current Organism:
Escherichia coli CFT073
NCBI taxonomy Id: 199310
Other names: E. coli CFT073, Escherichia coli str. CFT073, Escherichia coli strain CFT073
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