STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
gcvRGlycine cleavage system transcriptional repressor; Gcv operon repressor; Escherichia coli K-12 ortholog: b2479; Escherichia coli O157:H7 ortholog: z3738. (212 aa)    
Predicted Functional Partners:
gcvA
Glycine cleavage system transcriptional activator; Regulatory protein for the glycine cleavage system operon (gcv). Mediates activation of gcv by glycine and repression by purines. GcvA is negatively autoregulated. Binds to three sites upstream of the gcv promoter (By similarity); Belongs to the LysR transcriptional regulatory family.
  
 
 0.992
bcp
Bacterioferritin comigratory protein; Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides and as sensor of hydrogen peroxide-mediated signaling events; Belongs to the peroxiredoxin family. BCP/PrxQ subfamily.
  
    0.841
gcvP
Glycine dehydrogenase (decarboxylating); The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family.
  
  
 0.768
nlpB
Lipoprotein-34 precursor; Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane.
 
    0.722
ybeL
Hypothetical protein ybeL; Escherichia coli K-12 ortholog: b0643; Escherichia coli O157:H7 ortholog: z0790.
  
     0.706
dapA
Dihydrodipicolinate synthase; Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA).
  
    0.630
smg
Protein smg; Escherichia coli K-12 ortholog: b3284; Escherichia coli O157:H7 ortholog: z4655; Belongs to the Smg family.
  
    0.621
ypjD
Hypothetical protein ypjD; Escherichia coli K-12 ortholog: b2611; Escherichia coli O157:H7 ortholog: z3905.
  
    0.564
c1173
Hypothetical protein; Residues 19 to 68 of 68 are 83.99 pct identical to residues 204 to 253 of 287 from GenPept.129 : >gb|AAL22135.1| (AE008850) putative methyltransferase [Salmonella typhimurium LT2].
  
     0.545
yecM
Protein yecM; Escherichia coli K-12 ortholog: b1875; Escherichia coli O157:H7 ortholog: z2928.
  
     0.532
Your Current Organism:
Escherichia coli CFT073
NCBI taxonomy Id: 199310
Other names: E. coli CFT073, Escherichia coli str. CFT073, Escherichia coli strain CFT073
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