STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
hybBProbable Ni/Fe-hydrogenase 2 B-type cytochrome subunit; Escherichia coli K-12 ortholog: b2995; Escherichia coli O157:H7 ortholog: z4349. (392 aa)    
Predicted Functional Partners:
hybC
Hydrogenase-2 large chain precursor; Escherichia coli K-12 ortholog: b2994; Escherichia coli O157:H7 ortholog: z4348; Belongs to the [NiFe]/[NiFeSe] hydrogenase large subunit family.
 
 
 0.999
hybA
Hydrogenase-2 operon protein hybA precursor; Escherichia coli K-12 ortholog: b2996; Escherichia coli O157:H7 ortholog: z4350.
 0.999
hybO
Hydrogenase-2 small chain precursor; This is one of three E.coli hydrogenases synthesized in response to different physiological conditions. HYD2 is involved in hydrogen uptake.
 
 
 0.999
hybE
Hydrogenase-2 operon protein hybE; Escherichia coli K-12 ortholog: b2992; Escherichia coli O157:H7 ortholog: z4346; Belongs to the HupJ family.
 
  
 0.981
hybD
Hydrogenase 2 maturation protease; Escherichia coli K-12 ortholog: b2993; Escherichia coli O157:H7 ortholog: z4347.
 
  
 0.937
hybF
Probable hydrogenase nickel incorporation protein hybF; Involved in the maturation of [NiFe] hydrogenases. Required for nickel insertion into the metal center of the hydrogenase.
  
  
 0.851
dmsB
Anaerobic dimethyl sulfoxide reductase chain B; DMSO reductase iron-sulfur subunit; Escherichia coli K-12 ortholog: b0895; Escherichia coli O157:H7 ortholog: z1241.
 
 0.803
hyaB
Hydrogenase-1 large chain; Escherichia coli K-12 ortholog: b0973; Escherichia coli O157:H7 ortholog: z1390; Belongs to the [NiFe]/[NiFeSe] hydrogenase large subunit family.
 
  
 0.798
hybG
Hydrogenase-2 operon protein hybG; Involved in the maturation of [NiFe] hydrogenases. Involved in the biosynthesis of the Fe(CN)(2)CO cofactor. HybG delivers iron- bound CO(2) to HypD where reduction to CO probably occurs. In complex with HypD, accepts the cyanide ligand generated by HypF and HypE, and also coordinates the carbon monoxide ligand. Belongs to the HupF/HypC family.
     
 0.794
dmsA
Anaerobic dimethyl sulfoxide reductase chain A precursor; Escherichia coli K-12 ortholog: b0894; Escherichia coli O157:H7 ortholog: z1240; Belongs to the prokaryotic molybdopterin-containing oxidoreductase family.
  
 0.766
Your Current Organism:
Escherichia coli CFT073
NCBI taxonomy Id: 199310
Other names: E. coli CFT073, Escherichia coli str. CFT073, Escherichia coli strain CFT073
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