node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
barA | evgS | c3349 | c2906 | Sensor protein barA; Member of the two-component regulatory system UvrY/BarA involved in the regulation of carbon metabolism via the CsrA/CsrB regulatory system. Phosphorylates UvrY, probably via a four-step phosphorelay (By similarity). | Sensor protein evgS precursor; Escherichia coli K-12 ortholog: b2370; Escherichia coli O157:H7 ortholog: z3632. | 0.992 |
barA | yhbY | c3349 | c3937 | Sensor protein barA; Member of the two-component regulatory system UvrY/BarA involved in the regulation of carbon metabolism via the CsrA/CsrB regulatory system. Phosphorylates UvrY, probably via a four-step phosphorelay (By similarity). | Hypothetical protein yhbY; Escherichia coli K-12 ortholog: b3180; Escherichia coli O157:H7 ortholog: z4542. | 0.481 |
evgS | barA | c2906 | c3349 | Sensor protein evgS precursor; Escherichia coli K-12 ortholog: b2370; Escherichia coli O157:H7 ortholog: z3632. | Sensor protein barA; Member of the two-component regulatory system UvrY/BarA involved in the regulation of carbon metabolism via the CsrA/CsrB regulatory system. Phosphorylates UvrY, probably via a four-step phosphorelay (By similarity). | 0.992 |
evgS | yhbY | c2906 | c3937 | Sensor protein evgS precursor; Escherichia coli K-12 ortholog: b2370; Escherichia coli O157:H7 ortholog: z3632. | Hypothetical protein yhbY; Escherichia coli K-12 ortholog: b3180; Escherichia coli O157:H7 ortholog: z4542. | 0.430 |
ftsJ | yhbY | c3936 | c3937 | Ribosomal RNA large subunit methyltransferase J; Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit. | Hypothetical protein yhbY; Escherichia coli K-12 ortholog: b3180; Escherichia coli O157:H7 ortholog: z4542. | 0.632 |
infA | yhbY | c1021 | c3937 | Translation initiation factor IF-1; One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre-initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initiation complex. | Hypothetical protein yhbY; Escherichia coli K-12 ortholog: b3180; Escherichia coli O157:H7 ortholog: z4542. | 0.435 |
topA | yhbY | c1741 | c3937 | DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supe [...] | Hypothetical protein yhbY; Escherichia coli K-12 ortholog: b3180; Escherichia coli O157:H7 ortholog: z4542. | 0.456 |
ybcJ | yhbY | c0644 | c3937 | Hypothetical protein ybcJ; Escherichia coli K-12 ortholog: b0528; Escherichia coli O157:H7 ortholog: z0683. | Hypothetical protein yhbY; Escherichia coli K-12 ortholog: b3180; Escherichia coli O157:H7 ortholog: z4542. | 0.434 |
ybeB | ybeN | c0728 | c0730 | Hypothetical protein ybeB; Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation. | Nicotinate-nucleotide adenylyltransferase; Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD). | 0.840 |
ybeB | yhbY | c0728 | c3937 | Hypothetical protein ybeB; Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation. | Hypothetical protein yhbY; Escherichia coli K-12 ortholog: b3180; Escherichia coli O157:H7 ortholog: z4542. | 0.550 |
ybeB | yjgA | c0728 | c5332 | Hypothetical protein ybeB; Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation. | Hypothetical protein yjgA; X96 protein; Escherichia coli K-12 ortholog: b4234; Escherichia coli O157:H7 ortholog: z5844; Belongs to the UPF0307 family. | 0.802 |
ybeN | ybeB | c0730 | c0728 | Nicotinate-nucleotide adenylyltransferase; Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD). | Hypothetical protein ybeB; Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation. | 0.840 |
ybeN | yhbY | c0730 | c3937 | Nicotinate-nucleotide adenylyltransferase; Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD). | Hypothetical protein yhbY; Escherichia coli K-12 ortholog: b3180; Escherichia coli O157:H7 ortholog: z4542. | 0.764 |
yggJ | yhbY | c3532 | c3937 | Hypothetical protein yggJ; Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity); Belongs to the RNA methyltransferase RsmE family. | Hypothetical protein yhbY; Escherichia coli K-12 ortholog: b3180; Escherichia coli O157:H7 ortholog: z4542. | 0.419 |
yhbY | barA | c3937 | c3349 | Hypothetical protein yhbY; Escherichia coli K-12 ortholog: b3180; Escherichia coli O157:H7 ortholog: z4542. | Sensor protein barA; Member of the two-component regulatory system UvrY/BarA involved in the regulation of carbon metabolism via the CsrA/CsrB regulatory system. Phosphorylates UvrY, probably via a four-step phosphorelay (By similarity). | 0.481 |
yhbY | evgS | c3937 | c2906 | Hypothetical protein yhbY; Escherichia coli K-12 ortholog: b3180; Escherichia coli O157:H7 ortholog: z4542. | Sensor protein evgS precursor; Escherichia coli K-12 ortholog: b2370; Escherichia coli O157:H7 ortholog: z3632. | 0.430 |
yhbY | ftsJ | c3937 | c3936 | Hypothetical protein yhbY; Escherichia coli K-12 ortholog: b3180; Escherichia coli O157:H7 ortholog: z4542. | Ribosomal RNA large subunit methyltransferase J; Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit. | 0.632 |
yhbY | infA | c3937 | c1021 | Hypothetical protein yhbY; Escherichia coli K-12 ortholog: b3180; Escherichia coli O157:H7 ortholog: z4542. | Translation initiation factor IF-1; One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre-initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initiation complex. | 0.435 |
yhbY | topA | c3937 | c1741 | Hypothetical protein yhbY; Escherichia coli K-12 ortholog: b3180; Escherichia coli O157:H7 ortholog: z4542. | DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supe [...] | 0.456 |
yhbY | ybcJ | c3937 | c0644 | Hypothetical protein yhbY; Escherichia coli K-12 ortholog: b3180; Escherichia coli O157:H7 ortholog: z4542. | Hypothetical protein ybcJ; Escherichia coli K-12 ortholog: b0528; Escherichia coli O157:H7 ortholog: z0683. | 0.434 |