node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
cysC | cysD | c3317 | c3319 | Adenylylsulfate kinase; Catalyzes the synthesis of activated sulfate. | Sulfate adenylyltransferase subunit 2; Escherichia coli K-12 ortholog: b2752; Escherichia coli O157:H7 ortholog: z4060. | 0.999 |
cysC | cysG | c3317 | c4144 | Adenylylsulfate kinase; Catalyzes the synthesis of activated sulfate. | Siroheme synthase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. | 0.966 |
cysC | cysH | c3317 | c3321 | Adenylylsulfate kinase; Catalyzes the synthesis of activated sulfate. | Phosphoadenosine phosphosulfate reductase; Reduction of activated sulfate into sulfite. | 0.999 |
cysC | cysI | c3317 | c3322 | Adenylylsulfate kinase; Catalyzes the synthesis of activated sulfate. | Sulfite reductase [NADPH] hemoprotein beta-component; Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L-cysteine from sulfate. Belongs to the nitrite and sulfite reductase 4Fe-4S domain family. | 0.984 |
cysC | gltB | c3317 | c3973 | Adenylylsulfate kinase; Catalyzes the synthesis of activated sulfate. | Glutamate synthase [NADPH] large chain precursor; Escherichia coli K-12 ortholog: b3212; Escherichia coli O157:H7 ortholog: z4576. | 0.734 |
cysC | metH | c3317 | c4976 | Adenylylsulfate kinase; Catalyzes the synthesis of activated sulfate. | 5-methyltetrahydrofolate--homocysteine methyltransferase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | 0.410 |
cysD | cysC | c3319 | c3317 | Sulfate adenylyltransferase subunit 2; Escherichia coli K-12 ortholog: b2752; Escherichia coli O157:H7 ortholog: z4060. | Adenylylsulfate kinase; Catalyzes the synthesis of activated sulfate. | 0.999 |
cysD | cysG | c3319 | c4144 | Sulfate adenylyltransferase subunit 2; Escherichia coli K-12 ortholog: b2752; Escherichia coli O157:H7 ortholog: z4060. | Siroheme synthase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. | 0.939 |
cysD | cysH | c3319 | c3321 | Sulfate adenylyltransferase subunit 2; Escherichia coli K-12 ortholog: b2752; Escherichia coli O157:H7 ortholog: z4060. | Phosphoadenosine phosphosulfate reductase; Reduction of activated sulfate into sulfite. | 0.904 |
cysD | cysI | c3319 | c3322 | Sulfate adenylyltransferase subunit 2; Escherichia coli K-12 ortholog: b2752; Escherichia coli O157:H7 ortholog: z4060. | Sulfite reductase [NADPH] hemoprotein beta-component; Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L-cysteine from sulfate. Belongs to the nitrite and sulfite reductase 4Fe-4S domain family. | 0.996 |
cysD | gltB | c3319 | c3973 | Sulfate adenylyltransferase subunit 2; Escherichia coli K-12 ortholog: b2752; Escherichia coli O157:H7 ortholog: z4060. | Glutamate synthase [NADPH] large chain precursor; Escherichia coli K-12 ortholog: b3212; Escherichia coli O157:H7 ortholog: z4576. | 0.689 |
cysG | cysC | c4144 | c3317 | Siroheme synthase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. | Adenylylsulfate kinase; Catalyzes the synthesis of activated sulfate. | 0.966 |
cysG | cysD | c4144 | c3319 | Siroheme synthase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. | Sulfate adenylyltransferase subunit 2; Escherichia coli K-12 ortholog: b2752; Escherichia coli O157:H7 ortholog: z4060. | 0.939 |
cysG | cysH | c4144 | c3321 | Siroheme synthase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. | Phosphoadenosine phosphosulfate reductase; Reduction of activated sulfate into sulfite. | 0.973 |
cysG | cysI | c4144 | c3322 | Siroheme synthase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. | Sulfite reductase [NADPH] hemoprotein beta-component; Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L-cysteine from sulfate. Belongs to the nitrite and sulfite reductase 4Fe-4S domain family. | 0.982 |
cysG | gltB | c4144 | c3973 | Siroheme synthase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. | Glutamate synthase [NADPH] large chain precursor; Escherichia coli K-12 ortholog: b3212; Escherichia coli O157:H7 ortholog: z4576. | 0.955 |
cysG | hemC | c4144 | c4724 | Siroheme synthase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. | Porphobilinogen deaminase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. Belongs to the HMBS family. | 0.996 |
cysG | hemD | c4144 | c4723 | Siroheme synthase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. | Uroporphyrinogen-III synthase; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. | 0.979 |
cysG | hemE | c4144 | c4954 | Siroheme synthase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. | Uroporphyrinogen decarboxylase; Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III. | 0.973 |
cysG | metH | c4144 | c4976 | Siroheme synthase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. | 5-methyltetrahydrofolate--homocysteine methyltransferase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | 0.923 |