node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
argS | hisS | c2291 | c3036 | Arginyl-tRNA synthetase; Escherichia coli K-12 ortholog: b1876; Escherichia coli O157:H7 ortholog: z2929. | Histidyl-tRNA synthetase; Escherichia coli K-12 ortholog: b2514; Escherichia coli O157:H7 ortholog: z3777. | 0.922 |
argS | ileS | c2291 | c0030 | Arginyl-tRNA synthetase; Escherichia coli K-12 ortholog: b1876; Escherichia coli O157:H7 ortholog: z2929. | Isoleucyl-tRNA synthetase; Catalyzes the attachment of isoleucine to tRNA(Ile). As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile). Belongs to the class-I aminoacyl-tRNA synthetase family. IleS type 1 subfamily. | 0.986 |
argS | leuS | c2291 | c0733 | Arginyl-tRNA synthetase; Escherichia coli K-12 ortholog: b1876; Escherichia coli O157:H7 ortholog: z2929. | Leucyl-tRNA synthetase; Escherichia coli K-12 ortholog: b0642; Escherichia coli O157:H7 ortholog: z0789; Belongs to the class-I aminoacyl-tRNA synthetase family. | 0.985 |
argS | metG | c2291 | c2642 | Arginyl-tRNA synthetase; Escherichia coli K-12 ortholog: b1876; Escherichia coli O157:H7 ortholog: z2929. | Methionyl-tRNA synthetase; Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation. | 0.982 |
argS | serS | c2291 | c1030 | Arginyl-tRNA synthetase; Escherichia coli K-12 ortholog: b1876; Escherichia coli O157:H7 ortholog: z2929. | Seryl-tRNA synthetase; Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L- seryl-tRNA(Sec), which will be further converted into selenocysteinyl- tRNA(Sec). | 0.944 |
argS | trpS | c2291 | c4154 | Arginyl-tRNA synthetase; Escherichia coli K-12 ortholog: b1876; Escherichia coli O157:H7 ortholog: z2929. | Tryptophanyl-tRNA synthetase; Catalyzes the attachment of tryptophan to tRNA(Trp). Belongs to the class-I aminoacyl-tRNA synthetase family. | 0.879 |
argS | tyrS | c2291 | c2029 | Arginyl-tRNA synthetase; Escherichia coli K-12 ortholog: b1876; Escherichia coli O157:H7 ortholog: z2929. | Tyrosyl-tRNA synthetase; Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two- step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr); Belongs to the class-I aminoacyl-tRNA synthetase family. TyrS type 1 subfamily. | 0.948 |
argS | valS | c2291 | c5358 | Arginyl-tRNA synthetase; Escherichia coli K-12 ortholog: b1876; Escherichia coli O157:H7 ortholog: z2929. | Valyl-tRNA synthetase; Catalyzes the attachment of valine to tRNA(Val). As ValRS can inadvertently accommodate and process structurally similar amino acids such as threonine, to avoid such errors, it has a 'posttransfer' editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA- dependent manner; Belongs to the class-I aminoacyl-tRNA synthetase family. ValS type 1 subfamily. | 0.940 |
gph | rpe | c4155 | c4156 | Phosphoglycolate phosphatase; Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress. Belongs to the HAD-like hydrolase superfamily. CbbY/CbbZ/Gph/YieH family. | Ribulose-phosphate 3-epimerase; Catalyzes the reversible epimerization of D-ribulose 5- phosphate to D-xylulose 5-phosphate; Belongs to the ribulose-phosphate 3-epimerase family. | 0.864 |
gph | trpS | c4155 | c4154 | Phosphoglycolate phosphatase; Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress. Belongs to the HAD-like hydrolase superfamily. CbbY/CbbZ/Gph/YieH family. | Tryptophanyl-tRNA synthetase; Catalyzes the attachment of tryptophan to tRNA(Trp). Belongs to the class-I aminoacyl-tRNA synthetase family. | 0.847 |
hisS | argS | c3036 | c2291 | Histidyl-tRNA synthetase; Escherichia coli K-12 ortholog: b2514; Escherichia coli O157:H7 ortholog: z3777. | Arginyl-tRNA synthetase; Escherichia coli K-12 ortholog: b1876; Escherichia coli O157:H7 ortholog: z2929. | 0.922 |
hisS | ileS | c3036 | c0030 | Histidyl-tRNA synthetase; Escherichia coli K-12 ortholog: b2514; Escherichia coli O157:H7 ortholog: z3777. | Isoleucyl-tRNA synthetase; Catalyzes the attachment of isoleucine to tRNA(Ile). As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile). Belongs to the class-I aminoacyl-tRNA synthetase family. IleS type 1 subfamily. | 0.915 |
hisS | leuS | c3036 | c0733 | Histidyl-tRNA synthetase; Escherichia coli K-12 ortholog: b2514; Escherichia coli O157:H7 ortholog: z3777. | Leucyl-tRNA synthetase; Escherichia coli K-12 ortholog: b0642; Escherichia coli O157:H7 ortholog: z0789; Belongs to the class-I aminoacyl-tRNA synthetase family. | 0.895 |
hisS | metG | c3036 | c2642 | Histidyl-tRNA synthetase; Escherichia coli K-12 ortholog: b2514; Escherichia coli O157:H7 ortholog: z3777. | Methionyl-tRNA synthetase; Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation. | 0.887 |
hisS | serS | c3036 | c1030 | Histidyl-tRNA synthetase; Escherichia coli K-12 ortholog: b2514; Escherichia coli O157:H7 ortholog: z3777. | Seryl-tRNA synthetase; Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L- seryl-tRNA(Sec), which will be further converted into selenocysteinyl- tRNA(Sec). | 0.878 |
hisS | trpS | c3036 | c4154 | Histidyl-tRNA synthetase; Escherichia coli K-12 ortholog: b2514; Escherichia coli O157:H7 ortholog: z3777. | Tryptophanyl-tRNA synthetase; Catalyzes the attachment of tryptophan to tRNA(Trp). Belongs to the class-I aminoacyl-tRNA synthetase family. | 0.843 |
hisS | tyrS | c3036 | c2029 | Histidyl-tRNA synthetase; Escherichia coli K-12 ortholog: b2514; Escherichia coli O157:H7 ortholog: z3777. | Tyrosyl-tRNA synthetase; Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two- step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr); Belongs to the class-I aminoacyl-tRNA synthetase family. TyrS type 1 subfamily. | 0.873 |
hisS | valS | c3036 | c5358 | Histidyl-tRNA synthetase; Escherichia coli K-12 ortholog: b2514; Escherichia coli O157:H7 ortholog: z3777. | Valyl-tRNA synthetase; Catalyzes the attachment of valine to tRNA(Val). As ValRS can inadvertently accommodate and process structurally similar amino acids such as threonine, to avoid such errors, it has a 'posttransfer' editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA- dependent manner; Belongs to the class-I aminoacyl-tRNA synthetase family. ValS type 1 subfamily. | 0.913 |
ileS | argS | c0030 | c2291 | Isoleucyl-tRNA synthetase; Catalyzes the attachment of isoleucine to tRNA(Ile). As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile). Belongs to the class-I aminoacyl-tRNA synthetase family. IleS type 1 subfamily. | Arginyl-tRNA synthetase; Escherichia coli K-12 ortholog: b1876; Escherichia coli O157:H7 ortholog: z2929. | 0.986 |
ileS | hisS | c0030 | c3036 | Isoleucyl-tRNA synthetase; Catalyzes the attachment of isoleucine to tRNA(Ile). As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile). Belongs to the class-I aminoacyl-tRNA synthetase family. IleS type 1 subfamily. | Histidyl-tRNA synthetase; Escherichia coli K-12 ortholog: b2514; Escherichia coli O157:H7 ortholog: z3777. | 0.915 |