STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
sodASuperoxide dismutase (Mn); Destroys radicals which are normally produced within the cells and which are toxic to biological systems. Belongs to the iron/manganese superoxide dismutase family. (208 aa)    
Predicted Functional Partners:
sodC
Superoxide dismutase [Cu-Zn] precursor; Destroys radicals which are normally produced within the cells and which are toxic to biological systems. Belongs to the Cu-Zn superoxide dismutase family.
   
 
 0.935
katE
Catalase HPII; Serves to protect cells from the toxic effects of hydrogen peroxide.
  
 0.919
ydbK
Probable pyruvate-flavodoxin oxidoreductase; Escherichia coli K-12 ortholog: b1378; Escherichia coli O157:H7 ortholog: z2332.
  
  
 0.916
katG
Peroxidase/catalase HPI; Bifunctional enzyme with both catalase and broad-spectrum peroxidase activity; Belongs to the peroxidase family. Peroxidase/catalase subfamily.
     
 0.911
ahpC
Alkyl hydroperoxide reductase C22 protein; Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides.
  
  
 0.861
soxS
Regulatory protein soxS; Transcriptional activator of the superoxide response regulon of E.coli that includes at least 10 genes such as sodA, nfo, zwf and micF. Binds the DNA sequence 5'-GCACN(7)CAA-3'. It also facilitates the subsequent binding of RNA polymerase to the micF and the nfo promoters (By similarity).
   
  
 0.820
soxR
Redox-sensitive transcriptional activator soxR; Escherichia coli K-12 ortholog: b4063; Escherichia coli O157:H7 ortholog: z5662.
   
  
 0.818
gor
Glutathione reductase; Escherichia coli K-12 ortholog: b3500; Escherichia coli O157:H7 ortholog: z4900.
  
 
 0.755
ahpF
Alkyl hydroperoxide reductase subunit F; Escherichia coli K-12 ortholog: b0606; Escherichia coli O157:H7 ortholog: z0750.
  
  
 0.748
nfo
Endonuclease IV; Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic (AP) sites, generating a 3'-hydroxyl group and a 5'-terminal sugar phosphate.
  
  
 0.724
Your Current Organism:
Escherichia coli CFT073
NCBI taxonomy Id: 199310
Other names: E. coli CFT073, Escherichia coli str. CFT073, Escherichia coli strain CFT073
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