node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
arsC | coaA | c4301 | c4933 | Arsenate reductase; Escherichia coli K-12 ortholog: b3503; Escherichia coli O157:H7 ortholog: z4905. | Pantothenate kinase; Escherichia coli K-12 ortholog: b3974; Escherichia coli O157:H7 ortholog: z5545. | 0.435 |
birA | coaA | c4932 | c4933 | BirA bifunctional protein; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio-5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon. | Pantothenate kinase; Escherichia coli K-12 ortholog: b3974; Escherichia coli O157:H7 ortholog: z5545. | 0.461 |
birA | dfp | c4932 | c4463 | BirA bifunctional protein; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio-5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon. | DNA/pantothenate metabolism flavoprotein; Catalyzes two sequential steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'- phosphopantothenate to form 4-phosphopantothenoylcysteine. In the second step the latter compound is decarboxylated to form 4'- phosphopantotheine; In the C-terminal section; belongs to the PPC synthetase family. | 0.719 |
birA | kdtB | c4932 | c4458 | BirA bifunctional protein; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio-5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon. | Phosphopantetheine adenylyltransferase; Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate. Belongs to the bacterial CoaD family. | 0.483 |
birA | panC | c4932 | c0164 | BirA bifunctional protein; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio-5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon. | Pantoate--beta-alanine ligase; Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate. Belongs to the pantothenate synthetase family. | 0.760 |
c4934 | coaA | c4934 | c4933 | Hypothetical protein; Residues 1 to 53 of 53 are 96.22 pct identical to residues 1 to 53 of 53 from SwissProt.40 : >sp|P15045|YZRS_ECOLI VERY HYPOTHETICAL 6.2 KD PROTEIN IN RTS 5'REGION. | Pantothenate kinase; Escherichia coli K-12 ortholog: b3974; Escherichia coli O157:H7 ortholog: z5545. | 0.661 |
coaA | arsC | c4933 | c4301 | Pantothenate kinase; Escherichia coli K-12 ortholog: b3974; Escherichia coli O157:H7 ortholog: z5545. | Arsenate reductase; Escherichia coli K-12 ortholog: b3503; Escherichia coli O157:H7 ortholog: z4905. | 0.435 |
coaA | birA | c4933 | c4932 | Pantothenate kinase; Escherichia coli K-12 ortholog: b3974; Escherichia coli O157:H7 ortholog: z5545. | BirA bifunctional protein; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio-5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon. | 0.461 |
coaA | c4934 | c4933 | c4934 | Pantothenate kinase; Escherichia coli K-12 ortholog: b3974; Escherichia coli O157:H7 ortholog: z5545. | Hypothetical protein; Residues 1 to 53 of 53 are 96.22 pct identical to residues 1 to 53 of 53 from SwissProt.40 : >sp|P15045|YZRS_ECOLI VERY HYPOTHETICAL 6.2 KD PROTEIN IN RTS 5'REGION. | 0.661 |
coaA | dfp | c4933 | c4463 | Pantothenate kinase; Escherichia coli K-12 ortholog: b3974; Escherichia coli O157:H7 ortholog: z5545. | DNA/pantothenate metabolism flavoprotein; Catalyzes two sequential steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'- phosphopantothenate to form 4-phosphopantothenoylcysteine. In the second step the latter compound is decarboxylated to form 4'- phosphopantotheine; In the C-terminal section; belongs to the PPC synthetase family. | 0.981 |
coaA | kdtB | c4933 | c4458 | Pantothenate kinase; Escherichia coli K-12 ortholog: b3974; Escherichia coli O157:H7 ortholog: z5545. | Phosphopantetheine adenylyltransferase; Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate. Belongs to the bacterial CoaD family. | 0.982 |
coaA | mazG | c4933 | c3346 | Pantothenate kinase; Escherichia coli K-12 ortholog: b3974; Escherichia coli O157:H7 ortholog: z5545. | MazG protein; Escherichia coli K-12 ortholog: b2781; Escherichia coli O157:H7 ortholog: z4096. | 0.900 |
coaA | panC | c4933 | c0164 | Pantothenate kinase; Escherichia coli K-12 ortholog: b3974; Escherichia coli O157:H7 ortholog: z5545. | Pantoate--beta-alanine ligase; Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate. Belongs to the pantothenate synthetase family. | 0.960 |
coaA | yacE | c4933 | c0123 | Pantothenate kinase; Escherichia coli K-12 ortholog: b3974; Escherichia coli O157:H7 ortholog: z5545. | Dephospho-CoA kinase; Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A; Belongs to the CoaE family. | 0.859 |
coaA | yafK | c4933 | c0374 | Pantothenate kinase; Escherichia coli K-12 ortholog: b3974; Escherichia coli O157:H7 ortholog: z5545. | Hypothetical protein yafK precursor; Escherichia coli K-12 ortholog: b0224; Escherichia coli O157:H7 ortholog: z0282. | 0.467 |
coaA | yajB | c4933 | c0514 | Pantothenate kinase; Escherichia coli K-12 ortholog: b3974; Escherichia coli O157:H7 ortholog: z5545. | Hypothetical protein yajB; Converts holo-ACP to apo-ACP by hydrolytic cleavage of the phosphopantetheine prosthetic group from ACP; Belongs to the AcpH family. | 0.939 |
dfp | birA | c4463 | c4932 | DNA/pantothenate metabolism flavoprotein; Catalyzes two sequential steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'- phosphopantothenate to form 4-phosphopantothenoylcysteine. In the second step the latter compound is decarboxylated to form 4'- phosphopantotheine; In the C-terminal section; belongs to the PPC synthetase family. | BirA bifunctional protein; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio-5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon. | 0.719 |
dfp | coaA | c4463 | c4933 | DNA/pantothenate metabolism flavoprotein; Catalyzes two sequential steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'- phosphopantothenate to form 4-phosphopantothenoylcysteine. In the second step the latter compound is decarboxylated to form 4'- phosphopantotheine; In the C-terminal section; belongs to the PPC synthetase family. | Pantothenate kinase; Escherichia coli K-12 ortholog: b3974; Escherichia coli O157:H7 ortholog: z5545. | 0.981 |
dfp | kdtB | c4463 | c4458 | DNA/pantothenate metabolism flavoprotein; Catalyzes two sequential steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'- phosphopantothenate to form 4-phosphopantothenoylcysteine. In the second step the latter compound is decarboxylated to form 4'- phosphopantotheine; In the C-terminal section; belongs to the PPC synthetase family. | Phosphopantetheine adenylyltransferase; Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate. Belongs to the bacterial CoaD family. | 0.987 |
dfp | mazG | c4463 | c3346 | DNA/pantothenate metabolism flavoprotein; Catalyzes two sequential steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'- phosphopantothenate to form 4-phosphopantothenoylcysteine. In the second step the latter compound is decarboxylated to form 4'- phosphopantotheine; In the C-terminal section; belongs to the PPC synthetase family. | MazG protein; Escherichia coli K-12 ortholog: b2781; Escherichia coli O157:H7 ortholog: z4096. | 0.913 |