STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
yjdHSensor protein dcuS; Member of the two-component regulatory system DcuR/DcuS. Involved in the C4-dicarboxylate-stimulated regulation of the genes encoding the anaerobic fumarate respiratory system (frdABCD; nuoAN; dcuB; dcuC; sdhCDAB; etc.). Weakly regulates the aerobic C4- dicarboxylate transporter dctA. Activates DcuR by phosphorylation (By similarity). (543 aa)    
Predicted Functional Partners:
yjdG
Transcriptional Regulatory protein dcuR; Member of the two-component regulatory system DcuR/DcuS. Involved in the C4-dicarboxylate-stimulated regulation of the genes encoding the anaerobic fumarate respiratory system (frdABCD; nuoAN; dcuB; dcuC; sdhCDAB; etc.). Weakly regulates the aerobic C4- dicarboxylate transporter dctA (By similarity).
 
 0.999
citB
Transcriptional Regulatory protein dpiA; Member of the two-component regulatory system DpiA/DpiB, which is essential for expression of citrate-specific fermentation genes and genes involved in plasmid inheritance. Could be involved in response to both the presence of citrate and external redox conditions (By similarity).
 
 
 0.934
dcuB
Anaerobic C4-dicarboxylate transporter dcuB; Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane; Belongs to the DcuA/DcuB transporter (TC 2.A.13.1) family.
     
 0.905
dctA
Aerobic C4-dicarboxylate transport protein; Responsible for the aerobic transport of the dicarboxylates fumarate and malate and to a lesser extent succinate, from the periplasm across the inner membrane; Belongs to the dicarboxylate/amino acid:cation symporter (DAACS) (TC 2.A.23) family.
 
  
 0.850
phoQ
Sensor protein phoQ; Member of the two-component regulatory system PhoP/PhoQ involved in virulence, adaptation to low Mg(2+) environments and the control of acid resistance genes. In low periplasmic Mg(2+), PhoQ functions as a membrane-associated protein kinase that undergoes autophosphorylation and subsequently transfers the phosphate to PhoP, resulting in the expression of PhoP-activated genes (PAG) and repression of PhoP-repressed genes (PRG). In high periplasmic Mg(2+), acts as a protein phosphatase that dephosphorylates phospho-PhoP, which results in the repression of PG and may l [...]
      
 0.682
narX
Nitrate/nitrite sensor protein narX; Escherichia coli K-12 ortholog: b1222; Escherichia coli O157:H7 ortholog: z1998.
      
 0.682
c5132
Hypothetical protein.
       0.572
citA
Sensor kinase dpiB; Escherichia coli K-12 ortholog: b0619; Escherichia coli O157:H7 ortholog: z0764.
  
 
 
0.504
yjdJ
Hypothetical protein yjdJ; Escherichia coli K-12 ortholog: b4127; Escherichia coli O157:H7 ortholog: z5729.
  
    0.483
yjdI
Hypothetical protein yjdI; Escherichia coli K-12 ortholog: b4126; Escherichia coli O157:H7 ortholog: z5728.
  
    0.471
Your Current Organism:
Escherichia coli CFT073
NCBI taxonomy Id: 199310
Other names: E. coli CFT073, Escherichia coli str. CFT073, Escherichia coli strain CFT073
Server load: low (14%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.