STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
dsbDThiol:disulfide interchange protein dsbD precursor; Required to facilitate the formation of correct disulfide bonds in some periplasmic proteins and for the assembly of the periplasmic c-type cytochromes. Acts by transferring electrons from cytoplasmic thioredoxin to the periplasm. This transfer involves a cascade of disulfide bond formation and reduction steps. Belongs to the thioredoxin family. DsbD subfamily. (565 aa)    
Predicted Functional Partners:
dsbC
Thiol:disulfide interchange protein dsbC precursor; Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process; Belongs to the thioredoxin family. DsbC subfamily.
 
 
 0.998
dsbE
Thiol:disulfide interchange protein dsbE; Cytochrome c biogenesis protein ccmG; Escherichia coli K-12 ortholog: b2195; Escherichia coli O157:H7 ortholog: z3452.
  
 
 0.992
dsbB
Disulfide bond formation protein B; Required for disulfide bond formation in some periplasmic proteins such as PhoA or OmpA. Acts by oxidizing the DsbA protein (By similarity); Belongs to the DsbB family.
   
  
 0.957
cutA
Periplasmic divalent cation tolerance protein cutA; Involved in resistance toward heavy metals. Belongs to the CutA family.
  
  
 0.952
dsbG
Thiol:disulfide interchange protein dsbG precursor; Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process; Belongs to the thioredoxin family. DsbC subfamily.
  
 
 0.951
dsbA
Thiol:disulfide interchange protein dsbA precursor; Required for disulfide bond formation in some periplasmic proteins such as PhoA or OmpA. Acts by transferring its disulfide bond to other proteins and is reduced in the process. DsbA is reoxidized by DsbB. It is required for pilus biogenesis (By similarity). Belongs to the thioredoxin family. DsbA subfamily.
  
 
 0.943
yjdC
Protein yjdC; Escherichia coli K-12 ortholog: b4135; Escherichia coli O157:H7 ortholog: z5740.
     
 0.776
yeaA
Peptide methionine sulfoxide reductase msrB; Escherichia coli K-12 ortholog: b1778; Escherichia coli O157:H7 ortholog: z2817; Belongs to the MsrB Met sulfoxide reductase family.
 
 
 
 0.716
ccmH
Cytochrome c-type biogenesis protein ccmH precursor; Possible subunit of a heme lyase.
      
 0.682
msrA
Peptide methionine sulfoxide reductase msrA; Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity).
   
 
 0.676
Your Current Organism:
Escherichia coli CFT073
NCBI taxonomy Id: 199310
Other names: E. coli CFT073, Escherichia coli str. CFT073, Escherichia coli strain CFT073
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