STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ygdDHypothetical protein ygdD; Escherichia coli K-12 ortholog: b2807; Escherichia coli O157:H7 ortholog: z4124. (100 aa)    
Predicted Functional Partners:
ygdE
Hypothetical protein ygdE; Catalyzes the 2'-O-methylation at nucleotide C2498 in 23S rRNA; Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily.
  
  
 0.944
gcvA
Glycine cleavage system transcriptional activator; Regulatory protein for the glycine cleavage system operon (gcv). Mediates activation of gcv by glycine and repression by purines. GcvA is negatively autoregulated. Binds to three sites upstream of the gcv promoter (By similarity); Belongs to the LysR transcriptional regulatory family.
  
    0.929
sbmA
SbmA protein; Escherichia coli K-12 ortholog: b0377; Escherichia coli O157:H7 ortholog: z0473.
      
 0.820
yjiL
Hypothetical protein yjiL; Escherichia coli K-12 ortholog: b4334; Escherichia coli O157:H7 ortholog: z5936.
      
 0.819
ygdK
Hypothetical protein ygdK; Escherichia coli K-12 ortholog: b2811; Escherichia coli O157:H7 ortholog: z4128.
  
    0.634
ycbY
Hypothetical protein ycbY; Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA. Belongs to the methyltransferase superfamily. RlmKL family.
 
   
 0.511
yqjF
Hypothetical protein yqjF; Escherichia coli K-12 ortholog: b3101; Escherichia coli O157:H7 ortholog: z4455.
      
 0.418
yhhL
Hypothetical protein yhhL; Escherichia coli K-12 ortholog: b3466; Escherichia coli O157:H7 ortholog: z4840.
  
   
 0.412
Your Current Organism:
Escherichia coli CFT073
NCBI taxonomy Id: 199310
Other names: E. coli CFT073, Escherichia coli str. CFT073, Escherichia coli strain CFT073
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.