STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
yhhGNickel responsive regulator; Transcriptional repressor of the nikABCDE operon. Is active in the presence of excessive concentrations of intracellular nickel (By similarity). (133 aa)    
Predicted Functional Partners:
nikA
Nickel-binding periplasmic protein precursor; Escherichia coli K-12 ortholog: b3476; Escherichia coli O157:H7 ortholog: z4868.
     
 0.929
nikD
Nickel transport ATP-binding protein nikD; Part of the ABC transporter complex NikABCDE involved in nickel import. Responsible for energy coupling to the transport system. Belongs to the ABC transporter superfamily. Nickel importer (TC 3.A.1.5.3) family.
     
 0.877
nikC
Nickel transport system permease protein nikC; Escherichia coli K-12 ortholog: b3478; Escherichia coli O157:H7 ortholog: z4870.
  
  
 0.867
nikE
Nickel transport ATP-binding protein nikE; Part of the ABC transporter complex NikABCDE involved in nickel import. Responsible for energy coupling to the transport system. Belongs to the ABC transporter superfamily. Nickel importer (TC 3.A.1.5.3) family.
 
   
 0.852
nikB
Nickel transport system permease protein nikB; Escherichia coli K-12 ortholog: b3477; Escherichia coli O157:H7 ortholog: z4869.
     
 0.845
yohM
Hypothetical protein yohM; Efflux system for nickel and cobalt.
  
   
 0.844
yohL
Hypothetical protein yohL; Repressor of rcnA expression. Acts by binding specifically to the rcnA promoter in the absence of nickel and cobalt. In the presence of one of these metals, it has a weaker affinity for rcnA promoter (By similarity); Belongs to the FrmR/RcnR family.
      
 0.831
yhdM
Zn(II)-responsive regulator of zntA; Escherichia coli K-12 ortholog: b3292; Escherichia coli O157:H7 ortholog: z4662.
      
 0.682
birA
BirA bifunctional protein; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio-5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon.
     
 0.578
ybbI
Transcriptional regulator cueR; Regulates the transcription of the copA and cueO genes. It detects cytoplasmic copper stress and activates transcription in response to increasing copper concentrations (By similarity).
      
 0.561
Your Current Organism:
Escherichia coli CFT073
NCBI taxonomy Id: 199310
Other names: E. coli CFT073, Escherichia coli str. CFT073, Escherichia coli strain CFT073
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