GCA_001570385_02905 protein (Microtetraspora glauca)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

GCA_001570385_02905

Unannotated protein. (588 aa)

Predicted Functional Partners:

GCA_001570385_01374

0.687

GCA_001570385_00575

0.678

GCA_001570385_00517

0.653

GCA_001570385_04516

0.627

GCA_001570385_03028

0.626

GCA_001570385_00518

0.620

GCA_001570385_00969

0.619

GCA_001570385_00970

0.619

GCA_001570385_06106

0.619

GCA_001570385_07682

0.619

Your Current Organism:

Microtetraspora glauca

NCBI taxonomy Id: 1996
Other names: ATCC 23057, DSM 43311, IFO 14761, JCM 3300, M. glauca, NBRC 14761, NRRL B-3735, VKM Ac-663

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structured XML interaction data, according to the 'PSI-MI' data standard

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... protein annotations:

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... functional annotations:

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a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 annotation	node2 annotation	score
GCA_001570385_00517	GCA_001570385_00518	Unannotated protein.	Unannotated protein.	0.999
GCA_001570385_00517	GCA_001570385_00969	Unannotated protein.	Unannotated protein.	0.535
GCA_001570385_00517	GCA_001570385_00970	Unannotated protein.	Unannotated protein.	0.535
GCA_001570385_00517	GCA_001570385_01374	Unannotated protein.	Unannotated protein.	0.822
GCA_001570385_00517	GCA_001570385_02905	Unannotated protein.	Unannotated protein.	0.653
GCA_001570385_00517	GCA_001570385_03028	Unannotated protein.	Unannotated protein.	0.551
GCA_001570385_00517	GCA_001570385_06106	Unannotated protein.	Unannotated protein.	0.535
GCA_001570385_00517	GCA_001570385_07682	Unannotated protein.	Unannotated protein.	0.535
GCA_001570385_00518	GCA_001570385_00517	Unannotated protein.	Unannotated protein.	0.999
GCA_001570385_00518	GCA_001570385_00969	Unannotated protein.	Unannotated protein.	0.783
GCA_001570385_00518	GCA_001570385_00970	Unannotated protein.	Unannotated protein.	0.783
GCA_001570385_00518	GCA_001570385_01374	Unannotated protein.	Unannotated protein.	0.818
GCA_001570385_00518	GCA_001570385_02905	Unannotated protein.	Unannotated protein.	0.620
GCA_001570385_00518	GCA_001570385_03028	Unannotated protein.	Unannotated protein.	0.800
GCA_001570385_00518	GCA_001570385_06106	Unannotated protein.	Unannotated protein.	0.783
GCA_001570385_00518	GCA_001570385_07682	Unannotated protein.	Unannotated protein.	0.783
GCA_001570385_00575	GCA_001570385_02905	Unannotated protein.	Unannotated protein.	0.678
GCA_001570385_00969	GCA_001570385_00517	Unannotated protein.	Unannotated protein.	0.535
GCA_001570385_00969	GCA_001570385_00518	Unannotated protein.	Unannotated protein.	0.783
GCA_001570385_00969	GCA_001570385_00970	Unannotated protein.	Unannotated protein.	0.773

page 1 of 3

Network Stats

number of nodes:

11

number of edges:

35

average node degree:

6.36

avg. local clustering coefficient:

0.354

expected number of edges:

14

PPI enrichment p-value:

1.77e-06

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0007189

Adenylate cyclase-activating G protein-coupled receptor signaling pathway

5 of 113

1.9

2.23

1.69e-05

GO:0007186

G protein-coupled receptor signaling pathway

11 of 1117

1.25

1.94

2.11e-10

GO:0007212

Dopamine receptor signaling pathway

3 of 21

2.41

1.82

0.00040

GO:0007191

Adenylate cyclase-activating dopamine receptor signaling pathway

2 of 7

2.71

1.19

0.0069

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0030159

Signaling receptor complex adaptor activity

4 of 39

2.27

2.43

1.89e-05

GO:0031683

G-protein beta/gamma-subunit complex binding

2 of 22

2.21

0.77

0.0387

GO:0044877

Protein-containing complex binding

6 of 1127

0.98

0.64

0.0124

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005834

Heterotrimeric G-protein complex

7 of 33

2.58

6.71

3.94e-14

GO:0005886

Plasma membrane

11 of 4790

0.62

0.55

2.55e-05

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:33829

Mixed, incl. Heterotrimeric G-protein complex, and The phototransduction cascade

6 of 94

2.06

3.47

2.76e-08

CL:33835

Mixed, incl. G beta:gamma signalling through PLC beta, and Dopamine receptor signaling pathway

4 of 32

2.35

2.88

2.59e-06

CL:20896

Latrophilin Cytoplasmic C-terminal region, and GHH signature containing HNH/Endo VII superfamily nuclease toxin

3 of 6

2.95

2.86

6.08e-06

CL:33837

G beta:gamma signalling through PLC beta, and Dopamine receptor signaling pathway

3 of 21

2.41

2.12

0.00010

CL:33839

Adrenaline,noradrenaline inhibits insulin secretion, and G protein-coupled serotonin receptor binding

2 of 11

2.52

1.2

0.0063

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

pcw04728

Dopaminergic synapse

5 of 114

1.9

2.67

1.06e-06

pcw04727

GABAergic synapse

4 of 77

1.97

2.32

1.38e-05

pcw05032

Morphine addiction

4 of 82

1.94

2.3

1.38e-05

pcw04713

Circadian entrainment

4 of 86

1.92

2.28

1.38e-05

pcw04726

Serotonergic synapse

4 of 93

1.89

2.25

1.38e-05

(more ...)

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-373080

Class B/2 (Secretin family receptors)

8 of 61

2.37

6.7

3.91e-15

MAP-8964315

G beta:gamma signalling through BTK

6 of 18

2.78

6.47

4.14e-13

MAP-8964616

G beta:gamma signalling through CDC42

6 of 19

2.76

6.45

4.14e-13

MAP-418217

G beta:gamma signalling through PLC beta

6 of 20

2.73

6.42

4.25e-13

MAP-500657

Presynaptic function of Kainate receptors

6 of 21

2.71

6.39

4.55e-13

(more ...)

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0005834

Heterotrimeric G-protein complex

7 of 17

2.87

7.9

7.88e-16

GOCC:0005886

Plasma membrane

9 of 2573

0.8

0.73

6.85e-05

GOCC:0016020

Membrane

10 of 4798

0.57

0.47

0.00071

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0853

WD repeat

5 of 282

1.5

1.58

0.00010

KW-0807

Transducer

6 of 839

1.11

1.01

0.00045

KW-0677

Repeat

5 of 1247

0.86

0.47

0.0440

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF02354

Latrophilin Cytoplasmic C-terminal region

3 of 3

3.26

2.9

5.77e-06

PF02140

Galactose binding lectin domain

3 of 5

3.03

2.8

8.08e-06

PF16489

GPCR-Autoproteolysis INducing (GAIN) domain

3 of 10

2.73

2.48

2.75e-05

PF00002

7 transmembrane receptor (Secretin family)

3 of 47

2.06

1.47

0.0014

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00284

Olfactomedin-like domains

3 of 13

2.62

2.3

5.59e-05

SM00303

G-protein-coupled receptor proteolytic site domain

3 of 28

2.29

2.0

0.00015

SM00320

WD40 repeats

5 of 276

1.51

1.6

9.37e-05

SM00275

G protein alpha subunit

2 of 16

2.35

1.12

0.0084

SM00008

Domain present in hormone receptors

2 of 19

2.28

1.1

0.0092

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