GCA_001570385_07662 protein (Microtetraspora glauca)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

GCA_001570385_07662

Unannotated protein. (188 aa)

Predicted Functional Partners:

GCA_001570385_07661

0.952

GCA_001570385_01196

0.812

GCA_001570385_03290

0.786

GCA_001570385_03698

0.786

GCA_001570385_04332

0.783

GCA_001570385_00504

0.629

GCA_001570385_01648

0.546

GCA_001570385_00772

0.492

GCA_001570385_04508

0.491

GCA_001570385_05858

0.480

Your Current Organism:

Microtetraspora glauca

NCBI taxonomy Id: 1996
Other names: ATCC 23057, DSM 43311, IFO 14761, JCM 3300, M. glauca, NBRC 14761, NRRL B-3735, VKM Ac-663

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structured XML interaction data, according to the 'PSI-MI' data standard

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... functional annotations:

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a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 annotation	node2 annotation	score
GCA_001570385_00504	GCA_001570385_07661	Unannotated protein.	Unannotated protein.	0.459
GCA_001570385_00504	GCA_001570385_07662	Unannotated protein.	Unannotated protein.	0.629
GCA_001570385_00772	GCA_001570385_03290	Unannotated protein.	Unannotated protein.	0.999
GCA_001570385_00772	GCA_001570385_07662	Unannotated protein.	Unannotated protein.	0.492
GCA_001570385_01196	GCA_001570385_03290	Unannotated protein.	Unannotated protein.	0.877
GCA_001570385_01196	GCA_001570385_03698	Unannotated protein.	Unannotated protein.	0.880
GCA_001570385_01196	GCA_001570385_04332	Unannotated protein.	Unannotated protein.	0.884
GCA_001570385_01196	GCA_001570385_07662	Unannotated protein.	Unannotated protein.	0.812
GCA_001570385_01648	GCA_001570385_04508	Unannotated protein.	Unannotated protein.	0.548
GCA_001570385_01648	GCA_001570385_07661	Unannotated protein.	Unannotated protein.	0.409
GCA_001570385_01648	GCA_001570385_07662	Unannotated protein.	Unannotated protein.	0.546
GCA_001570385_03290	GCA_001570385_00772	Unannotated protein.	Unannotated protein.	0.999
GCA_001570385_03290	GCA_001570385_01196	Unannotated protein.	Unannotated protein.	0.877
GCA_001570385_03290	GCA_001570385_07662	Unannotated protein.	Unannotated protein.	0.786
GCA_001570385_03698	GCA_001570385_01196	Unannotated protein.	Unannotated protein.	0.880
GCA_001570385_03698	GCA_001570385_07662	Unannotated protein.	Unannotated protein.	0.786
GCA_001570385_04332	GCA_001570385_01196	Unannotated protein.	Unannotated protein.	0.884
GCA_001570385_04332	GCA_001570385_07662	Unannotated protein.	Unannotated protein.	0.783
GCA_001570385_04508	GCA_001570385_01648	Unannotated protein.	Unannotated protein.	0.548
GCA_001570385_04508	GCA_001570385_07661	Unannotated protein.	Unannotated protein.	0.490

page 1 of 2

Network Stats

number of nodes:

11

number of edges:

48

average node degree:

8.73

avg. local clustering coefficient:

0.867

expected number of edges:

13

PPI enrichment p-value:

7.77e-14

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0050853

B cell receptor signaling pathway

4 of 17

2.65

3.3

6.51e-07

GO:0043687

Post-translational protein modification

4 of 28

2.44

2.94

2.34e-06

GO:0035162

Embryonic hemopoiesis

4 of 36

2.33

2.74

4.95e-06

GO:0042113

B cell activation

4 of 71

2.03

2.16

4.12e-05

GO:0007596

Blood coagulation

4 of 74

2.01

2.15

4.17e-05

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0035403

Histone kinase activity (H3-T6 specific)

4 of 4

3.28

4.47

7.57e-09

GO:0050681

Nuclear androgen receptor binding

4 of 16

2.68

3.61

1.74e-07

GO:0004698

Calcium-dependent protein kinase C activity

4 of 23

2.52

3.37

3.78e-07

GO:0030374

Nuclear receptor coactivator activity

4 of 42

2.26

2.89

1.94e-06

GO:0015279

Store-operated calcium channel activity

2 of 12

2.5

1.34

0.0035

(more ...)

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005923

Bicellular tight junction

3 of 110

1.72

0.77

0.0304

GO:0016324

Apical plasma membrane

3 of 190

1.48

0.69

0.0374

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:8304

Mixed, incl. L27 domain, and PB1 domain

5 of 27

2.55

4.12

1.18e-08

CL:34179

Transient receptor ion channel II, and Protein kinase C, alpha/beta/gamma types

3 of 5

3.06

2.85

6.52e-06

CL:8307

Tight junction interactions, and Transmembrane protein 237

3 of 21

2.44

2.07

0.00013

CL:8337

L27 domain

2 of 6

2.8

1.45

0.0023

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map04370

VEGF signaling pathway

4 of 89

1.93

2.2

2.26e-05

map04012

ErbB signaling pathway

4 of 128

1.78

1.95

4.63e-05

map04912

GnRH signaling pathway

4 of 140

1.74

1.92

4.63e-05

map04540

Gap junction

4 of 144

1.72

1.91

4.63e-05

map04916

Melanogenesis

4 of 148

1.71

1.9

4.63e-05

(more ...)

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-114516

Disinhibition of SNARE formation

4 of 7

3.04

4.17

2.23e-08

MAP-5099900

WNT5A-dependent internalization of FZD4

4 of 14

2.74

3.74

1.03e-07

MAP-416993

Trafficking of GluR2-containing AMPA receptors

4 of 27

2.45

3.21

7.04e-07

MAP-399721

Glutamate binding, activation of AMPA receptors and synaptic plasticity

4 of 30

2.41

3.16

7.78e-07

MAP-399719

Trafficking of AMPA receptors

4 of 30

2.41

3.16

7.78e-07

(more ...)

Tissue Expression (TISSUES)

tissue

description

count in network

strength

signal

false discovery rate

BTO:0001489

Whole body

11 of 12264

0.23

0.22

0.0243

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0016324

Apical plasma membrane

3 of 53

2.03

1.23

0.0044

GOCC:0005923

Bicellular tight junction

3 of 58

1.99

1.22

0.0044

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0723

Serine/threonine-protein kinase

3 of 227

1.4

0.66

0.0395

KW-0863

Zinc-finger

5 of 1069

0.95

0.52

0.0395

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR014375

Protein kinase C, alpha/beta/gamma types

3 of 3

3.28

2.68

1.45e-05

IPR020454

Diacylglycerol/phorbol-ester binding

3 of 24

2.38

1.59

0.0011

IPR015132

L27-2

2 of 2

3.28

1.45

0.0025

IPR017892

Protein kinase, C-terminal

3 of 34

2.23

1.44

0.0019

IPR000961

AGC-kinase, C-terminal

3 of 65

1.94

1.18

0.0051

(more ...)

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00133

Extension to Ser/Thr-type protein kinases

4 of 69

2.04

2.2

3.39e-05

SM00109

Protein kinase C conserved region 1 (C1) domains (Cysteine-rich domains)

4 of 82

1.97

2.16

3.39e-05

SM00228

Domain present in PSD-95, Dlg, and ZO-1/2.

5 of 208

1.66

1.89

3.39e-05

SM00239

Protein kinase C conserved region 2 (CalB)

4 of 178

1.63

1.53

0.00033

SM01420

Transient receptor ion channel II

2 of 8

2.68

1.52

0.0017

(more ...)

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