node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
SCX93898.1 | SCY28936.1 | SAMN05216420_101390 | SAMN05216420_104125 | ATP-dependent protease ClpP, protease subunit. | Curved DNA-binding protein. | 0.497 |
SCX93898.1 | dnaJ | SAMN05216420_101390 | SAMN05216420_10673 | ATP-dependent protease ClpP, protease subunit. | Molecular chaperone DnaJ; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, [...] | 0.535 |
SCX93898.1 | dnaK | SAMN05216420_101390 | SAMN05216420_10674 | ATP-dependent protease ClpP, protease subunit. | Molecular chaperone DnaK; Acts as a chaperone; Belongs to the heat shock protein 70 family. | 0.746 |
SCX93898.1 | groL | SAMN05216420_101390 | SAMN05216420_12121 | ATP-dependent protease ClpP, protease subunit. | Chaperonin GroEL; Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions. | 0.622 |
SCX93898.1 | grpE | SAMN05216420_101390 | SAMN05216420_10675 | ATP-dependent protease ClpP, protease subunit. | Molecular chaperone GrpE; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP [...] | 0.657 |
SCX93898.1 | hrcA | SAMN05216420_101390 | SAMN05216420_103163 | ATP-dependent protease ClpP, protease subunit. | Heat-inducible transcription repressor HrcA; Negative regulator of class I heat shock genes (grpE-dnaK- dnaJ and groELS operons). Prevents heat-shock induction of these operons. | 0.773 |
SCY20321.1 | dnaK | SAMN05216420_103165 | SAMN05216420_10674 | DNA replication and repair protein RecN; May be involved in recombinational repair of damaged DNA. | Molecular chaperone DnaK; Acts as a chaperone; Belongs to the heat shock protein 70 family. | 0.427 |
SCY20321.1 | hemH | SAMN05216420_103165 | SAMN05216420_103162 | DNA replication and repair protein RecN; May be involved in recombinational repair of damaged DNA. | Ferrochelatase; Catalyzes the ferrous insertion into protoporphyrin IX. Belongs to the ferrochelatase family. | 0.484 |
SCY20321.1 | hrcA | SAMN05216420_103165 | SAMN05216420_103163 | DNA replication and repair protein RecN; May be involved in recombinational repair of damaged DNA. | Heat-inducible transcription repressor HrcA; Negative regulator of class I heat shock genes (grpE-dnaK- dnaJ and groELS operons). Prevents heat-shock induction of these operons. | 0.589 |
SCY28936.1 | SCX93898.1 | SAMN05216420_104125 | SAMN05216420_101390 | Curved DNA-binding protein. | ATP-dependent protease ClpP, protease subunit. | 0.497 |
SCY28936.1 | SCY36209.1 | SAMN05216420_104125 | SAMN05216420_10565 | Curved DNA-binding protein. | Transcriptional regulator, MerR family. | 0.892 |
SCY28936.1 | clpP | SAMN05216420_104125 | SAMN05216420_12116 | Curved DNA-binding protein. | ATP-dependent Clp protease proteolytic subunit ClpP; Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family. | 0.497 |
SCY28936.1 | dnaK | SAMN05216420_104125 | SAMN05216420_10674 | Curved DNA-binding protein. | Molecular chaperone DnaK; Acts as a chaperone; Belongs to the heat shock protein 70 family. | 0.999 |
SCY28936.1 | groL | SAMN05216420_104125 | SAMN05216420_12121 | Curved DNA-binding protein. | Chaperonin GroEL; Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions. | 0.837 |
SCY28936.1 | grpE | SAMN05216420_104125 | SAMN05216420_10675 | Curved DNA-binding protein. | Molecular chaperone GrpE; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP [...] | 0.958 |
SCY28936.1 | hrcA | SAMN05216420_104125 | SAMN05216420_103163 | Curved DNA-binding protein. | Heat-inducible transcription repressor HrcA; Negative regulator of class I heat shock genes (grpE-dnaK- dnaJ and groELS operons). Prevents heat-shock induction of these operons. | 0.780 |
SCY36209.1 | SCY28936.1 | SAMN05216420_10565 | SAMN05216420_104125 | Transcriptional regulator, MerR family. | Curved DNA-binding protein. | 0.892 |
SCY36209.1 | dnaJ | SAMN05216420_10565 | SAMN05216420_10673 | Transcriptional regulator, MerR family. | Molecular chaperone DnaJ; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, [...] | 0.892 |
SCY36209.1 | dnaK | SAMN05216420_10565 | SAMN05216420_10674 | Transcriptional regulator, MerR family. | Molecular chaperone DnaK; Acts as a chaperone; Belongs to the heat shock protein 70 family. | 0.577 |
SCY36209.1 | grpE | SAMN05216420_10565 | SAMN05216420_10675 | Transcriptional regulator, MerR family. | Molecular chaperone GrpE; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP [...] | 0.513 |