node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
SDG58000.1 | hisA | SAMN05216553_109176 | SAMN05216553_10714 | D,D-heptose 1,7-bisphosphate phosphatase; Haloacid dehalogenase superfamily, subfamily IA, variant 3 with third motif having DD or ED/haloacid dehalogenase superfamily, subfamily IA, variant 1 with third motif having Dx(3-4)D or Dx(3-4)E. | 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase. | 0.761 |
SDG58000.1 | hisC | SAMN05216553_109176 | SAMN05216553_10724 | D,D-heptose 1,7-bisphosphate phosphatase; Haloacid dehalogenase superfamily, subfamily IA, variant 3 with third motif having DD or ED/haloacid dehalogenase superfamily, subfamily IA, variant 1 with third motif having Dx(3-4)D or Dx(3-4)E. | Histidinol-phosphate aminotransferase; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. | 0.776 |
SDG58000.1 | hisD | SAMN05216553_109176 | SAMN05216553_10725 | D,D-heptose 1,7-bisphosphate phosphatase; Haloacid dehalogenase superfamily, subfamily IA, variant 3 with third motif having DD or ED/haloacid dehalogenase superfamily, subfamily IA, variant 1 with third motif having Dx(3-4)D or Dx(3-4)E. | Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. | 0.912 |
SDG58000.1 | hisE | SAMN05216553_109176 | SAMN05216553_10179 | D,D-heptose 1,7-bisphosphate phosphatase; Haloacid dehalogenase superfamily, subfamily IA, variant 3 with third motif having DD or ED/haloacid dehalogenase superfamily, subfamily IA, variant 1 with third motif having Dx(3-4)D or Dx(3-4)E. | phosphoribosyl-ATP pyrophosphatase. | 0.821 |
SDG58000.1 | hisF | SAMN05216553_109176 | SAMN05216553_10711 | D,D-heptose 1,7-bisphosphate phosphatase; Haloacid dehalogenase superfamily, subfamily IA, variant 3 with third motif having DD or ED/haloacid dehalogenase superfamily, subfamily IA, variant 1 with third motif having Dx(3-4)D or Dx(3-4)E. | Cyclase; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. | 0.918 |
SDG58000.1 | hisG | SAMN05216553_109176 | SAMN05216553_10180 | D,D-heptose 1,7-bisphosphate phosphatase; Haloacid dehalogenase superfamily, subfamily IA, variant 3 with third motif having DD or ED/haloacid dehalogenase superfamily, subfamily IA, variant 1 with third motif having Dx(3-4)D or Dx(3-4)E. | ATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Long subfamily. | 0.765 |
SDG58000.1 | hisH | SAMN05216553_109176 | SAMN05216553_10715 | D,D-heptose 1,7-bisphosphate phosphatase; Haloacid dehalogenase superfamily, subfamily IA, variant 3 with third motif having DD or ED/haloacid dehalogenase superfamily, subfamily IA, variant 1 with third motif having Dx(3-4)D or Dx(3-4)E. | Glutamine amidotransferase; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. | 0.946 |
SDG58000.1 | hisI | SAMN05216553_109176 | SAMN05216553_1079 | D,D-heptose 1,7-bisphosphate phosphatase; Haloacid dehalogenase superfamily, subfamily IA, variant 3 with third motif having DD or ED/haloacid dehalogenase superfamily, subfamily IA, variant 1 with third motif having Dx(3-4)D or Dx(3-4)E. | phosphoribosyl-AMP cyclohydrolase; Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP. | 0.824 |
SDG94459.1 | hisA | SAMN05216553_113239 | SAMN05216553_10714 | Glutamate synthase (NADPH/NADH) large chain. | 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase. | 0.556 |
SDG94459.1 | hisB | SAMN05216553_113239 | SAMN05216553_10723 | Glutamate synthase (NADPH/NADH) large chain. | Imidazoleglycerol-phosphate dehydratase. | 0.670 |
SDG94459.1 | hisD | SAMN05216553_113239 | SAMN05216553_10725 | Glutamate synthase (NADPH/NADH) large chain. | Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. | 0.669 |
SDG94459.1 | hisE | SAMN05216553_113239 | SAMN05216553_10179 | Glutamate synthase (NADPH/NADH) large chain. | phosphoribosyl-ATP pyrophosphatase. | 0.812 |
SDG94459.1 | hisF | SAMN05216553_113239 | SAMN05216553_10711 | Glutamate synthase (NADPH/NADH) large chain. | Cyclase; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. | 0.961 |
SDG94459.1 | hisG | SAMN05216553_113239 | SAMN05216553_10180 | Glutamate synthase (NADPH/NADH) large chain. | ATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Long subfamily. | 0.493 |
SDG94459.1 | hisH | SAMN05216553_113239 | SAMN05216553_10715 | Glutamate synthase (NADPH/NADH) large chain. | Glutamine amidotransferase; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. | 0.928 |
SDG94459.1 | hisI | SAMN05216553_113239 | SAMN05216553_1079 | Glutamate synthase (NADPH/NADH) large chain. | phosphoribosyl-AMP cyclohydrolase; Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP. | 0.830 |
hisA | SDG58000.1 | SAMN05216553_10714 | SAMN05216553_109176 | 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase. | D,D-heptose 1,7-bisphosphate phosphatase; Haloacid dehalogenase superfamily, subfamily IA, variant 3 with third motif having DD or ED/haloacid dehalogenase superfamily, subfamily IA, variant 1 with third motif having Dx(3-4)D or Dx(3-4)E. | 0.761 |
hisA | SDG94459.1 | SAMN05216553_10714 | SAMN05216553_113239 | 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase. | Glutamate synthase (NADPH/NADH) large chain. | 0.556 |
hisA | hisB | SAMN05216553_10714 | SAMN05216553_10723 | 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase. | Imidazoleglycerol-phosphate dehydratase. | 0.998 |
hisA | hisC | SAMN05216553_10714 | SAMN05216553_10724 | 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase. | Histidinol-phosphate aminotransferase; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. | 0.971 |