STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
SDH13281.1Iron (metal) dependent repressor, DtxR family. (231 aa)    
Predicted Functional Partners:
SDG18134.1
Dihydrofolate synthase / folylpolyglutamate synthase; Belongs to the folylpolyglutamate synthase family.
 
  
  0.876
SDH13261.1
Galactokinase; Belongs to the GHMP kinase family. GalK subfamily.
       0.860
SDG79276.1
D-methionine transport system ATP-binding protein; Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system; Belongs to the ABC transporter superfamily. Methionine importer (TC 3.A.1.24) family.
   
   0.837
SDG97378.1
Zinc/manganese transport system permease protein.
  
 
 0.792
SDG97335.1
Zinc/manganese transport system substrate-binding protein; Belongs to the bacterial solute-binding protein 9 family.
  
 
 0.791
SDH37579.1
Fur family transcriptional regulator, ferric uptake regulator; Belongs to the Fur family.
  
  
 0.787
SDG97352.1
Zinc/manganese transport system ATP-binding protein.
  
 
 0.785
thyA
Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
    
 0.784
gcvP
Glycine dehydrogenase; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family.
    
  0.779
SDH13239.1
UDP-glucose 4-epimerase; Belongs to the NAD(P)-dependent epimerase/dehydratase family.
     
 0.743
Your Current Organism:
Lechevalieria fradiae
NCBI taxonomy Id: 200378
Other names: AS 4.3506, CGMCC 4.3506, DSM 45099, JCM 14205, L. fradiae, Lechevalieria fradiae Zhang et al. 2007, strain Z6
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