node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
SHE51385.1 | SHF01439.1 | SAMN05444320_101287 | SAMN05444320_102258 | NTP pyrophosphatase, house-cleaning of non-canonical NTPs. | Ribonucleoside-diphosphate reductase alpha chain; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. | 0.757 |
SHE51385.1 | dcd | SAMN05444320_101287 | SAMN05444320_101499 | NTP pyrophosphatase, house-cleaning of non-canonical NTPs. | dCTP deaminase; Bifunctional enzyme that catalyzes both the deamination of dCTP to dUTP and the hydrolysis of dUTP to dUMP without releasing the toxic dUTP intermediate. | 0.718 |
SHE51385.1 | ndk | SAMN05444320_101287 | SAMN05444320_103663 | NTP pyrophosphatase, house-cleaning of non-canonical NTPs. | Nucleoside diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family. | 0.719 |
SHF01439.1 | SHE51385.1 | SAMN05444320_102258 | SAMN05444320_101287 | Ribonucleoside-diphosphate reductase alpha chain; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. | NTP pyrophosphatase, house-cleaning of non-canonical NTPs. | 0.757 |
SHF01439.1 | SHF88221.1 | SAMN05444320_102258 | SAMN05444320_105334 | Ribonucleoside-diphosphate reductase alpha chain; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. | MazG-like family protein. | 0.757 |
SHF01439.1 | SHG56208.1 | SAMN05444320_102258 | SAMN05444320_11051 | Ribonucleoside-diphosphate reductase alpha chain; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. | XTP/dITP diphosphohydrolase. | 0.565 |
SHF01439.1 | dcd | SAMN05444320_102258 | SAMN05444320_101499 | Ribonucleoside-diphosphate reductase alpha chain; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. | dCTP deaminase; Bifunctional enzyme that catalyzes both the deamination of dCTP to dUTP and the hydrolysis of dUTP to dUMP without releasing the toxic dUTP intermediate. | 0.822 |
SHF01439.1 | dut | SAMN05444320_102258 | SAMN05444320_103375 | Ribonucleoside-diphosphate reductase alpha chain; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. | Deoxyuridine 5'-triphosphate nucleotidohydrolase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA; Belongs to the dUTPase family. | 0.949 |
SHF01439.1 | ndk | SAMN05444320_102258 | SAMN05444320_103663 | Ribonucleoside-diphosphate reductase alpha chain; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. | Nucleoside diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family. | 0.942 |
SHF01439.1 | pyrG | SAMN05444320_102258 | SAMN05444320_111119 | Ribonucleoside-diphosphate reductase alpha chain; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. | CTP synthase; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates. | 0.851 |
SHF01439.1 | tmk | SAMN05444320_102258 | SAMN05444320_101921 | Ribonucleoside-diphosphate reductase alpha chain; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. | dTMP kinase; Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis; Belongs to the thymidylate kinase family. | 0.907 |
SHF88221.1 | SHF01439.1 | SAMN05444320_105334 | SAMN05444320_102258 | MazG-like family protein. | Ribonucleoside-diphosphate reductase alpha chain; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. | 0.757 |
SHF88221.1 | dcd | SAMN05444320_105334 | SAMN05444320_101499 | MazG-like family protein. | dCTP deaminase; Bifunctional enzyme that catalyzes both the deamination of dCTP to dUTP and the hydrolysis of dUTP to dUMP without releasing the toxic dUTP intermediate. | 0.718 |
SHF88221.1 | ndk | SAMN05444320_105334 | SAMN05444320_103663 | MazG-like family protein. | Nucleoside diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family. | 0.719 |
SHG47510.1 | dcd | SAMN05444320_109135 | SAMN05444320_101499 | dTDP-4-dehydrorhamnose reductase; Catalyzes the reduction of dTDP-6-deoxy-L-lyxo-4-hexulose to yield dTDP-L-rhamnose. | dCTP deaminase; Bifunctional enzyme that catalyzes both the deamination of dCTP to dUTP and the hydrolysis of dUTP to dUMP without releasing the toxic dUTP intermediate. | 0.694 |
SHG56208.1 | SHF01439.1 | SAMN05444320_11051 | SAMN05444320_102258 | XTP/dITP diphosphohydrolase. | Ribonucleoside-diphosphate reductase alpha chain; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. | 0.565 |
SHG56208.1 | dcd | SAMN05444320_11051 | SAMN05444320_101499 | XTP/dITP diphosphohydrolase. | dCTP deaminase; Bifunctional enzyme that catalyzes both the deamination of dCTP to dUTP and the hydrolysis of dUTP to dUMP without releasing the toxic dUTP intermediate. | 0.789 |
SHG56208.1 | dut | SAMN05444320_11051 | SAMN05444320_103375 | XTP/dITP diphosphohydrolase. | Deoxyuridine 5'-triphosphate nucleotidohydrolase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA; Belongs to the dUTPase family. | 0.519 |
SHG56208.1 | pyrG | SAMN05444320_11051 | SAMN05444320_111119 | XTP/dITP diphosphohydrolase. | CTP synthase; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates. | 0.774 |
dcd | SHE51385.1 | SAMN05444320_101499 | SAMN05444320_101287 | dCTP deaminase; Bifunctional enzyme that catalyzes both the deamination of dCTP to dUTP and the hydrolysis of dUTP to dUMP without releasing the toxic dUTP intermediate. | NTP pyrophosphatase, house-cleaning of non-canonical NTPs. | 0.718 |