STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Cthe_1168PFAM: AMMECR1 domain protein; Extradiol ring-cleavage dioxygenase class III protein subunit B; KEGG: tpd:Teth39_0581 hypothetical protein. (462 aa)    
Predicted Functional Partners:
Cthe_1167
KEGG: csc:Csac_1182 radical SAM domain-containing protein; PFAM: Radical SAM domain protein; SMART: Elongator protein 3/MiaB/NifB.
 
    0.962
Cthe_3344
Hypothetical protein.
       0.762
Cthe_1165
PFAM: YbbR family protein; KEGG: cce:Ccel_1202 YbbR family protein.
       0.654
dacA
Protein of unknown function DUF147; Catalyzes the condensation of 2 ATP molecules into cyclic di- AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria.
       0.654
Cthe_1454
KEGG: ctc:CTC02440 hypothetical protein.
 
    0.520
nnrD
Carbohydrate kinase, YjeF related protein; Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S-specific NAD(P)H-hydrate dehydratase to allow t [...]
  
  
 0.510
Cthe_1164
PFAM: FAD-dependent pyridine nucleotide-disulfide oxidoreductase; fumarate reductase/succinate dehydrogenase flavoprotein domain protein; KEGG: cce:Ccel_1203 FAD dependent oxidoreductase.
       0.503
Cthe_0503
2'-5' RNA ligase; Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester; Belongs to the 2H phosphoesterase superfamily. ThpR family.
 
    0.479
hisD
Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine.
  
    0.435
Cthe_3005
KEGG: amt:Amet_4134 peptidoglycan-binding LysM; PFAM: Peptidoglycan-binding lysin domain; SMART: Peptidoglycan-binding LysM.
 
    0.410
Your Current Organism:
Hungateiclostridium thermocellum
NCBI taxonomy Id: 203119
Other names: Clostridium thermocellum ATCC 27405, H. thermocellum ATCC 27405, Hungateiclostridium thermocellum ATCC 27405, Ruminiclostridium thermocellum ATCC 27405
Server load: low (30%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.