node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Cthe_0423 | Cthe_0551 | Cthe_0423 | Cthe_0551 | PFAM: iron-containing alcohol dehydrogenase; Aldehyde Dehydrogenase; KEGG: emi:Emin_0755 bifunctional acetaldehyde-CoA/alcohol dehydrogenase; In the C-terminal section; belongs to the iron-containing alcohol dehydrogenase family. | PFAM: AMP-dependent synthetase and ligase; KEGG: AMP-dependent synthetase and ligase. | 0.972 |
Cthe_0423 | Cthe_0856 | Cthe_0423 | Cthe_0856 | PFAM: iron-containing alcohol dehydrogenase; Aldehyde Dehydrogenase; KEGG: emi:Emin_0755 bifunctional acetaldehyde-CoA/alcohol dehydrogenase; In the C-terminal section; belongs to the iron-containing alcohol dehydrogenase family. | TIGRFAM: branched-chain amino acid aminotransferase; KEGG: cce:Ccel_1877 branched-chain amino acid aminotransferase; PFAM: aminotransferase class IV. | 0.460 |
Cthe_0423 | Cthe_2516 | Cthe_0423 | Cthe_2516 | PFAM: iron-containing alcohol dehydrogenase; Aldehyde Dehydrogenase; KEGG: emi:Emin_0755 bifunctional acetaldehyde-CoA/alcohol dehydrogenase; In the C-terminal section; belongs to the iron-containing alcohol dehydrogenase family. | KEGG: cce:Ccel_3437 acetolactate synthase, large subunit, biosynthetic type; TIGRFAM: acetolactate synthase, large subunit, biosynthetic type; PFAM: thiamine pyrophosphate TPP-binding domain-containing protein; thiamine pyrophosphate central domain-containing protein. | 0.548 |
Cthe_0423 | Cthe_3120 | Cthe_0423 | Cthe_3120 | PFAM: iron-containing alcohol dehydrogenase; Aldehyde Dehydrogenase; KEGG: emi:Emin_0755 bifunctional acetaldehyde-CoA/alcohol dehydrogenase; In the C-terminal section; belongs to the iron-containing alcohol dehydrogenase family. | KEGG: cbl:CLK_0631 pyruvate ferredoxin oxidoreductase; TIGRFAM: pyruvate ferredoxin/flavodoxin oxidoreductase; PFAM: pyruvate flavodoxin/ferredoxin oxidoreductase domain protein; Pyruvate/ketoisovalerate oxidoreductase, catalytic domain; Pyruvate-flavodoxin oxidoreductase, EKR domain; thiamine pyrophosphate TPP-binding domain-containing protein. | 0.972 |
Cthe_0423 | ilvD | Cthe_0423 | Cthe_2713 | PFAM: iron-containing alcohol dehydrogenase; Aldehyde Dehydrogenase; KEGG: emi:Emin_0755 bifunctional acetaldehyde-CoA/alcohol dehydrogenase; In the C-terminal section; belongs to the iron-containing alcohol dehydrogenase family. | TIGRFAM: dihydroxy-acid dehydratase; KEGG: cce:Ccel_0302 dihydroxy-acid dehydratase; PFAM: dihydroxy-acid and 6-phosphogluconate dehydratase; Belongs to the IlvD/Edd family. | 0.562 |
Cthe_0423 | leuA | Cthe_0423 | Cthe_1391 | PFAM: iron-containing alcohol dehydrogenase; Aldehyde Dehydrogenase; KEGG: emi:Emin_0755 bifunctional acetaldehyde-CoA/alcohol dehydrogenase; In the C-terminal section; belongs to the iron-containing alcohol dehydrogenase family. | 2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily. | 0.939 |
Cthe_0423 | leuB | Cthe_0423 | Cthe_2209 | PFAM: iron-containing alcohol dehydrogenase; Aldehyde Dehydrogenase; KEGG: emi:Emin_0755 bifunctional acetaldehyde-CoA/alcohol dehydrogenase; In the C-terminal section; belongs to the iron-containing alcohol dehydrogenase family. | 3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. | 0.473 |
Cthe_0551 | Cthe_0423 | Cthe_0551 | Cthe_0423 | PFAM: AMP-dependent synthetase and ligase; KEGG: AMP-dependent synthetase and ligase. | PFAM: iron-containing alcohol dehydrogenase; Aldehyde Dehydrogenase; KEGG: emi:Emin_0755 bifunctional acetaldehyde-CoA/alcohol dehydrogenase; In the C-terminal section; belongs to the iron-containing alcohol dehydrogenase family. | 0.972 |
Cthe_0551 | Cthe_3120 | Cthe_0551 | Cthe_3120 | PFAM: AMP-dependent synthetase and ligase; KEGG: AMP-dependent synthetase and ligase. | KEGG: cbl:CLK_0631 pyruvate ferredoxin oxidoreductase; TIGRFAM: pyruvate ferredoxin/flavodoxin oxidoreductase; PFAM: pyruvate flavodoxin/ferredoxin oxidoreductase domain protein; Pyruvate/ketoisovalerate oxidoreductase, catalytic domain; Pyruvate-flavodoxin oxidoreductase, EKR domain; thiamine pyrophosphate TPP-binding domain-containing protein. | 0.975 |
Cthe_0551 | leuA | Cthe_0551 | Cthe_1391 | PFAM: AMP-dependent synthetase and ligase; KEGG: AMP-dependent synthetase and ligase. | 2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily. | 0.940 |
Cthe_0856 | Cthe_0423 | Cthe_0856 | Cthe_0423 | TIGRFAM: branched-chain amino acid aminotransferase; KEGG: cce:Ccel_1877 branched-chain amino acid aminotransferase; PFAM: aminotransferase class IV. | PFAM: iron-containing alcohol dehydrogenase; Aldehyde Dehydrogenase; KEGG: emi:Emin_0755 bifunctional acetaldehyde-CoA/alcohol dehydrogenase; In the C-terminal section; belongs to the iron-containing alcohol dehydrogenase family. | 0.460 |
Cthe_0856 | Cthe_2516 | Cthe_0856 | Cthe_2516 | TIGRFAM: branched-chain amino acid aminotransferase; KEGG: cce:Ccel_1877 branched-chain amino acid aminotransferase; PFAM: aminotransferase class IV. | KEGG: cce:Ccel_3437 acetolactate synthase, large subunit, biosynthetic type; TIGRFAM: acetolactate synthase, large subunit, biosynthetic type; PFAM: thiamine pyrophosphate TPP-binding domain-containing protein; thiamine pyrophosphate central domain-containing protein. | 0.860 |
Cthe_0856 | Cthe_3120 | Cthe_0856 | Cthe_3120 | TIGRFAM: branched-chain amino acid aminotransferase; KEGG: cce:Ccel_1877 branched-chain amino acid aminotransferase; PFAM: aminotransferase class IV. | KEGG: cbl:CLK_0631 pyruvate ferredoxin oxidoreductase; TIGRFAM: pyruvate ferredoxin/flavodoxin oxidoreductase; PFAM: pyruvate flavodoxin/ferredoxin oxidoreductase domain protein; Pyruvate/ketoisovalerate oxidoreductase, catalytic domain; Pyruvate-flavodoxin oxidoreductase, EKR domain; thiamine pyrophosphate TPP-binding domain-containing protein. | 0.404 |
Cthe_0856 | ilvC | Cthe_0856 | Cthe_2518 | TIGRFAM: branched-chain amino acid aminotransferase; KEGG: cce:Ccel_1877 branched-chain amino acid aminotransferase; PFAM: aminotransferase class IV. | Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. | 0.890 |
Cthe_0856 | ilvD | Cthe_0856 | Cthe_2713 | TIGRFAM: branched-chain amino acid aminotransferase; KEGG: cce:Ccel_1877 branched-chain amino acid aminotransferase; PFAM: aminotransferase class IV. | TIGRFAM: dihydroxy-acid dehydratase; KEGG: cce:Ccel_0302 dihydroxy-acid dehydratase; PFAM: dihydroxy-acid and 6-phosphogluconate dehydratase; Belongs to the IlvD/Edd family. | 0.997 |
Cthe_0856 | leuA | Cthe_0856 | Cthe_1391 | TIGRFAM: branched-chain amino acid aminotransferase; KEGG: cce:Ccel_1877 branched-chain amino acid aminotransferase; PFAM: aminotransferase class IV. | 2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily. | 0.985 |
Cthe_0856 | leuB | Cthe_0856 | Cthe_2209 | TIGRFAM: branched-chain amino acid aminotransferase; KEGG: cce:Ccel_1877 branched-chain amino acid aminotransferase; PFAM: aminotransferase class IV. | 3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. | 0.736 |
Cthe_0856 | leuC | Cthe_0856 | Cthe_2211 | TIGRFAM: branched-chain amino acid aminotransferase; KEGG: cce:Ccel_1877 branched-chain amino acid aminotransferase; PFAM: aminotransferase class IV. | 3-isopropylmalate dehydratase, large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. | 0.672 |
Cthe_0856 | leuD | Cthe_0856 | Cthe_2210 | TIGRFAM: branched-chain amino acid aminotransferase; KEGG: cce:Ccel_1877 branched-chain amino acid aminotransferase; PFAM: aminotransferase class IV. | 3-isopropylmalate dehydratase, small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 2 subfamily. | 0.764 |
Cthe_2516 | Cthe_0423 | Cthe_2516 | Cthe_0423 | KEGG: cce:Ccel_3437 acetolactate synthase, large subunit, biosynthetic type; TIGRFAM: acetolactate synthase, large subunit, biosynthetic type; PFAM: thiamine pyrophosphate TPP-binding domain-containing protein; thiamine pyrophosphate central domain-containing protein. | PFAM: iron-containing alcohol dehydrogenase; Aldehyde Dehydrogenase; KEGG: emi:Emin_0755 bifunctional acetaldehyde-CoA/alcohol dehydrogenase; In the C-terminal section; belongs to the iron-containing alcohol dehydrogenase family. | 0.548 |