node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Sde_0346 | Sde_0348 | Sde_0346 | Sde_0348 | Transcriptional regulator, XRE family. | Phosphoenolpyruvate-protein phosphotransferase; Belongs to the PEP-utilizing enzyme family. | 0.576 |
Sde_0346 | lgt | Sde_0346 | Sde_0349 | Transcriptional regulator, XRE family. | Prolipoprotein diacylglyceryl transferase; Catalyzes the transfer of the diacylglyceryl group from phosphatidylglycerol to the sulfhydryl group of the N-terminal cysteine of a prolipoprotein, the first step in the formation of mature lipoproteins; Belongs to the Lgt family. | 0.421 |
Sde_0346 | rppH | Sde_0346 | Sde_0347 | Transcriptional regulator, XRE family. | NUDIX hydrolase; Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage; Belongs to the Nudix hydrolase family. RppH subfamily. | 0.622 |
Sde_0348 | Sde_0346 | Sde_0348 | Sde_0346 | Phosphoenolpyruvate-protein phosphotransferase; Belongs to the PEP-utilizing enzyme family. | Transcriptional regulator, XRE family. | 0.576 |
Sde_0348 | Sde_0351 | Sde_0348 | Sde_0351 | Phosphoenolpyruvate-protein phosphotransferase; Belongs to the PEP-utilizing enzyme family. | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | 0.504 |
Sde_0348 | Sde_0755 | Sde_0348 | Sde_0755 | Phosphoenolpyruvate-protein phosphotransferase; Belongs to the PEP-utilizing enzyme family. | Cyclic nucleotide-binding. | 0.464 |
Sde_0348 | Sde_2016 | Sde_0348 | Sde_2016 | Phosphoenolpyruvate-protein phosphotransferase; Belongs to the PEP-utilizing enzyme family. | sohB peptidase. Serine peptidase. MEROPS family S49. | 0.458 |
Sde_0348 | Sde_3180 | Sde_0348 | Sde_3180 | Phosphoenolpyruvate-protein phosphotransferase; Belongs to the PEP-utilizing enzyme family. | Response regulator receiver sensor signal transduction histidine kinase. | 0.909 |
Sde_0348 | Sde_3182 | Sde_0348 | Sde_3182 | Phosphoenolpyruvate-protein phosphotransferase; Belongs to the PEP-utilizing enzyme family. | Phosphotransferase system, HPr. | 0.974 |
Sde_0348 | Sde_3374 | Sde_0348 | Sde_3374 | Phosphoenolpyruvate-protein phosphotransferase; Belongs to the PEP-utilizing enzyme family. | Two-component sensor kinase CbrA. | 0.457 |
Sde_0348 | lgt | Sde_0348 | Sde_0349 | Phosphoenolpyruvate-protein phosphotransferase; Belongs to the PEP-utilizing enzyme family. | Prolipoprotein diacylglyceryl transferase; Catalyzes the transfer of the diacylglyceryl group from phosphatidylglycerol to the sulfhydryl group of the N-terminal cysteine of a prolipoprotein, the first step in the formation of mature lipoproteins; Belongs to the Lgt family. | 0.544 |
Sde_0348 | rppH | Sde_0348 | Sde_0347 | Phosphoenolpyruvate-protein phosphotransferase; Belongs to the PEP-utilizing enzyme family. | NUDIX hydrolase; Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage; Belongs to the Nudix hydrolase family. RppH subfamily. | 0.846 |
Sde_0348 | thyA | Sde_0348 | Sde_0350 | Phosphoenolpyruvate-protein phosphotransferase; Belongs to the PEP-utilizing enzyme family. | Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. | 0.514 |
Sde_0351 | Sde_0348 | Sde_0351 | Sde_0348 | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | Phosphoenolpyruvate-protein phosphotransferase; Belongs to the PEP-utilizing enzyme family. | 0.504 |
Sde_0351 | lgt | Sde_0351 | Sde_0349 | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | Prolipoprotein diacylglyceryl transferase; Catalyzes the transfer of the diacylglyceryl group from phosphatidylglycerol to the sulfhydryl group of the N-terminal cysteine of a prolipoprotein, the first step in the formation of mature lipoproteins; Belongs to the Lgt family. | 0.772 |
Sde_0351 | rppH | Sde_0351 | Sde_0347 | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | NUDIX hydrolase; Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage; Belongs to the Nudix hydrolase family. RppH subfamily. | 0.506 |
Sde_0351 | thyA | Sde_0351 | Sde_0350 | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. | 0.999 |
Sde_0755 | Sde_0348 | Sde_0755 | Sde_0348 | Cyclic nucleotide-binding. | Phosphoenolpyruvate-protein phosphotransferase; Belongs to the PEP-utilizing enzyme family. | 0.464 |
Sde_0755 | Sde_3180 | Sde_0755 | Sde_3180 | Cyclic nucleotide-binding. | Response regulator receiver sensor signal transduction histidine kinase. | 0.463 |
Sde_0755 | Sde_3182 | Sde_0755 | Sde_3182 | Cyclic nucleotide-binding. | Phosphotransferase system, HPr. | 0.444 |