node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Sde_1614 | Sde_1615 | Sde_1614 | Sde_1615 | Protein of unknown function DUF195. | Conserved hypothetical protein. | 0.837 |
Sde_1614 | murI | Sde_1614 | Sde_1613 | Protein of unknown function DUF195. | Glutamate racemase; Provides the (R)-glutamate required for cell wall biosynthesis. | 0.540 |
Sde_1615 | Sde_1614 | Sde_1615 | Sde_1614 | Conserved hypothetical protein. | Protein of unknown function DUF195. | 0.837 |
Sde_1615 | murI | Sde_1615 | Sde_1613 | Conserved hypothetical protein. | Glutamate racemase; Provides the (R)-glutamate required for cell wall biosynthesis. | 0.540 |
Sde_2683 | glsA | Sde_2683 | Sde_2867 | Glutamate synthase (NADPH) large subunit. | Glutaminase; Belongs to the glutaminase family. | 0.941 |
Sde_2683 | murD | Sde_2683 | Sde_0846 | Glutamate synthase (NADPH) large subunit. | UDP-N-acetylmuramoylalanine--D-glutamate ligase; Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA). Belongs to the MurCDEF family. | 0.556 |
Sde_2683 | murE | Sde_2683 | Sde_0843 | Glutamate synthase (NADPH) large subunit. | UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan. Belongs to the MurCDEF family. MurE subfamily. | 0.492 |
Sde_2683 | murI | Sde_2683 | Sde_1613 | Glutamate synthase (NADPH) large subunit. | Glutamate racemase; Provides the (R)-glutamate required for cell wall biosynthesis. | 0.524 |
Sde_3647 | murI | Sde_3647 | Sde_1613 | Ham1-like protein; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | Glutamate racemase; Provides the (R)-glutamate required for cell wall biosynthesis. | 0.915 |
glsA | Sde_2683 | Sde_2867 | Sde_2683 | Glutaminase; Belongs to the glutaminase family. | Glutamate synthase (NADPH) large subunit. | 0.941 |
glsA | murD | Sde_2867 | Sde_0846 | Glutaminase; Belongs to the glutaminase family. | UDP-N-acetylmuramoylalanine--D-glutamate ligase; Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA). Belongs to the MurCDEF family. | 0.901 |
glsA | murI | Sde_2867 | Sde_1613 | Glutaminase; Belongs to the glutaminase family. | Glutamate racemase; Provides the (R)-glutamate required for cell wall biosynthesis. | 0.924 |
mraY | murC | Sde_0845 | Sde_0849 | Phospho-N-acetylmuramoyl-pentapeptide- transferase; First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan; Belongs to the glycosyltransferase 4 family. MraY subfamily. | UDP-N-acetylmuramate--L-alanine ligase; Cell wall formation; Belongs to the MurCDEF family. | 0.984 |
mraY | murD | Sde_0845 | Sde_0846 | Phospho-N-acetylmuramoyl-pentapeptide- transferase; First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan; Belongs to the glycosyltransferase 4 family. MraY subfamily. | UDP-N-acetylmuramoylalanine--D-glutamate ligase; Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA). Belongs to the MurCDEF family. | 0.996 |
mraY | murE | Sde_0845 | Sde_0843 | Phospho-N-acetylmuramoyl-pentapeptide- transferase; First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan; Belongs to the glycosyltransferase 4 family. MraY subfamily. | UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan. Belongs to the MurCDEF family. MurE subfamily. | 0.979 |
mraY | murF | Sde_0845 | Sde_0844 | Phospho-N-acetylmuramoyl-pentapeptide- transferase; First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan; Belongs to the glycosyltransferase 4 family. MraY subfamily. | UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase; Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein; Belongs to the MurCDEF family. MurF subfamily. | 0.999 |
mraY | murI | Sde_0845 | Sde_1613 | Phospho-N-acetylmuramoyl-pentapeptide- transferase; First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan; Belongs to the glycosyltransferase 4 family. MraY subfamily. | Glutamate racemase; Provides the (R)-glutamate required for cell wall biosynthesis. | 0.528 |
murC | mraY | Sde_0849 | Sde_0845 | UDP-N-acetylmuramate--L-alanine ligase; Cell wall formation; Belongs to the MurCDEF family. | Phospho-N-acetylmuramoyl-pentapeptide- transferase; First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan; Belongs to the glycosyltransferase 4 family. MraY subfamily. | 0.984 |
murC | murD | Sde_0849 | Sde_0846 | UDP-N-acetylmuramate--L-alanine ligase; Cell wall formation; Belongs to the MurCDEF family. | UDP-N-acetylmuramoylalanine--D-glutamate ligase; Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA). Belongs to the MurCDEF family. | 0.999 |
murC | murE | Sde_0849 | Sde_0843 | UDP-N-acetylmuramate--L-alanine ligase; Cell wall formation; Belongs to the MurCDEF family. | UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan. Belongs to the MurCDEF family. MurE subfamily. | 0.996 |