STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
Score
Tery_37572-isopropylmalate synthase; PFAM: pyruvate carboxyltransferase; KEGG: pae:PA1217 2-isopropylmalate synthase; Belongs to the alpha-IPM synthase/homocitrate synthase family. (462 aa)    
Predicted Functional Partners:
Tery_1041
TIGRFAM: 3-isopropylmalate dehydratase, small subunit; PFAM: aconitate hydratase-like; KEGG: cme:CMO094C 3-isopropylmalate dehydratase small subunit; Belongs to the LeuD family.
 
 
 0.990
Tery_2728
TIGRFAM: homoaconitate hydratase family protein 3-isopropylmalate dehydratase; PFAM: aconitate hydratase-like; KEGG: cme:CMS078C 3-isopropylmalate dehydratase Pfam: Aconitase; Belongs to the aconitase/IPM isomerase family.
 
 0.986
ilvD
KEGG: ava:Ava_0023 dihydroxy-acid dehydratase; TIGRFAM: dihydroxy-acid dehydratase; PFAM: dihydroxy-acid and 6-phosphogluconate dehydratase; Belongs to the IlvD/Edd family.
 
 
 0.980
Tery_0889
KEGG: sep:SE0318 branched-chain amino acid aminotroansferase-like protein; TIGRFAM: branched-chain amino acid aminotransferase; PFAM: aminotransferase, class IV.
  
 0.971
Tery_3707
Acetyl-coenzyme A carboxylase carboxyl transferase subunit alpha / biotin carboxylase; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA.
  
 
 0.952
Tery_2843
TIGRFAM: acetolactate synthase, large subunit, biosynthetic type; PFAM: thiamine pyrophosphate enzyme-like TPP-binding thiamine pyrophosphate enzyme, central region thiamine pyrophosphate enzyme-like TPP binding region; KEGG: ana:all4613 acetolactate synthase large subunit.
 
 
 0.937
leuA
2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.
  
  
 
0.927
acsA
Acetyl-coenzyme A synthetase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA; Belongs to the ATP-dependent AMP-binding enzyme family.
  
 
 0.927
Tery_0286
TIGRFAM: 2-isopropylmalate synthase/homocitrate synthase family protein; PFAM: pyruvate carboxyltransferase LeuA allosteric (dimerisation) domain; KEGG: ana:alr3522 2-isopropylmalate synthase; Belongs to the alpha-IPM synthase/homocitrate synthase family.
  
  
 
0.926
leuB
3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate.
 
 0.921
Your Current Organism:
Trichodesmium erythraeum
NCBI taxonomy Id: 203124
Other names: T. erythraeum IMS101, Trichodesmium erythraeum IMS101, Trichodesmium erythraeum str. IMS101, Trichodesmium erythraeum strain IMS101, Trichodesmium sp. IMS101
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