| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| TWT_592 | dnaK | TWT_592 | TWT_750 | Ribosomal protein acetyltransferase. | Chaperone protein; Acts as a chaperone; Belongs to the heat shock protein 70 family. | 0.587 |
| TWT_592 | guaA | TWT_592 | TWT_079 | Ribosomal protein acetyltransferase. | GMP synthase; Catalyzes the synthesis of GMP from XMP. | 0.702 |
| TWT_592 | tadA | TWT_592 | TWT_751 | Ribosomal protein acetyltransferase. | Unknown; Catalyzes the deamination of adenosine to inosine at the wobble position 34 of tRNA(Arg2); Belongs to the cytidine and deoxycytidylate deaminase family. | 0.529 |
| cbpA | clpB | TWT_748 | TWT_746 | Curved DNA-binding protein. | ATP-dependent protase ATP-binding subunit; Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE. Acts before DnaK, in the processing of protein aggregates. Protein binding stimulates the ATPase activity; ATP hydrolysis unfolds the denatured protein aggregates, which probably helps expose new hydrophobic binding sites on the surface of ClpB-bound aggregates, contributing to the solubilization and refolding of denatured protein aggregates by DnaK (By similarity). Belongs to the ClpA/C [...] | 0.903 |
| cbpA | dnaK | TWT_748 | TWT_750 | Curved DNA-binding protein. | Chaperone protein; Acts as a chaperone; Belongs to the heat shock protein 70 family. | 0.998 |
| cbpA | grpE | TWT_748 | TWT_749 | Curved DNA-binding protein. | HSP-70 cofactor GrpE; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dep [...] | 0.983 |
| cbpA | hspR | TWT_748 | TWT_747 | Curved DNA-binding protein. | Heat shock regulator. | 0.926 |
| cbpA | proC | TWT_748 | TWT_752 | Curved DNA-binding protein. | Pyrroline-5-carboxylate reductase; Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline. | 0.408 |
| cbpA | tadA | TWT_748 | TWT_751 | Curved DNA-binding protein. | Unknown; Catalyzes the deamination of adenosine to inosine at the wobble position 34 of tRNA(Arg2); Belongs to the cytidine and deoxycytidylate deaminase family. | 0.469 |
| clpB | cbpA | TWT_746 | TWT_748 | ATP-dependent protase ATP-binding subunit; Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE. Acts before DnaK, in the processing of protein aggregates. Protein binding stimulates the ATPase activity; ATP hydrolysis unfolds the denatured protein aggregates, which probably helps expose new hydrophobic binding sites on the surface of ClpB-bound aggregates, contributing to the solubilization and refolding of denatured protein aggregates by DnaK (By similarity). Belongs to the ClpA/C [...] | Curved DNA-binding protein. | 0.903 |
| clpB | dnaK | TWT_746 | TWT_750 | ATP-dependent protase ATP-binding subunit; Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE. Acts before DnaK, in the processing of protein aggregates. Protein binding stimulates the ATPase activity; ATP hydrolysis unfolds the denatured protein aggregates, which probably helps expose new hydrophobic binding sites on the surface of ClpB-bound aggregates, contributing to the solubilization and refolding of denatured protein aggregates by DnaK (By similarity). Belongs to the ClpA/C [...] | Chaperone protein; Acts as a chaperone; Belongs to the heat shock protein 70 family. | 0.984 |
| clpB | grpE | TWT_746 | TWT_749 | ATP-dependent protase ATP-binding subunit; Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE. Acts before DnaK, in the processing of protein aggregates. Protein binding stimulates the ATPase activity; ATP hydrolysis unfolds the denatured protein aggregates, which probably helps expose new hydrophobic binding sites on the surface of ClpB-bound aggregates, contributing to the solubilization and refolding of denatured protein aggregates by DnaK (By similarity). Belongs to the ClpA/C [...] | HSP-70 cofactor GrpE; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dep [...] | 0.943 |
| clpB | hspR | TWT_746 | TWT_747 | ATP-dependent protase ATP-binding subunit; Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE. Acts before DnaK, in the processing of protein aggregates. Protein binding stimulates the ATPase activity; ATP hydrolysis unfolds the denatured protein aggregates, which probably helps expose new hydrophobic binding sites on the surface of ClpB-bound aggregates, contributing to the solubilization and refolding of denatured protein aggregates by DnaK (By similarity). Belongs to the ClpA/C [...] | Heat shock regulator. | 0.855 |
| clpB | tadA | TWT_746 | TWT_751 | ATP-dependent protase ATP-binding subunit; Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE. Acts before DnaK, in the processing of protein aggregates. Protein binding stimulates the ATPase activity; ATP hydrolysis unfolds the denatured protein aggregates, which probably helps expose new hydrophobic binding sites on the surface of ClpB-bound aggregates, contributing to the solubilization and refolding of denatured protein aggregates by DnaK (By similarity). Belongs to the ClpA/C [...] | Unknown; Catalyzes the deamination of adenosine to inosine at the wobble position 34 of tRNA(Arg2); Belongs to the cytidine and deoxycytidylate deaminase family. | 0.549 |
| dnaK | TWT_592 | TWT_750 | TWT_592 | Chaperone protein; Acts as a chaperone; Belongs to the heat shock protein 70 family. | Ribosomal protein acetyltransferase. | 0.587 |
| dnaK | cbpA | TWT_750 | TWT_748 | Chaperone protein; Acts as a chaperone; Belongs to the heat shock protein 70 family. | Curved DNA-binding protein. | 0.998 |
| dnaK | clpB | TWT_750 | TWT_746 | Chaperone protein; Acts as a chaperone; Belongs to the heat shock protein 70 family. | ATP-dependent protase ATP-binding subunit; Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE. Acts before DnaK, in the processing of protein aggregates. Protein binding stimulates the ATPase activity; ATP hydrolysis unfolds the denatured protein aggregates, which probably helps expose new hydrophobic binding sites on the surface of ClpB-bound aggregates, contributing to the solubilization and refolding of denatured protein aggregates by DnaK (By similarity). Belongs to the ClpA/C [...] | 0.984 |
| dnaK | grpE | TWT_750 | TWT_749 | Chaperone protein; Acts as a chaperone; Belongs to the heat shock protein 70 family. | HSP-70 cofactor GrpE; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dep [...] | 0.999 |
| dnaK | guaA | TWT_750 | TWT_079 | Chaperone protein; Acts as a chaperone; Belongs to the heat shock protein 70 family. | GMP synthase; Catalyzes the synthesis of GMP from XMP. | 0.521 |
| dnaK | hspR | TWT_750 | TWT_747 | Chaperone protein; Acts as a chaperone; Belongs to the heat shock protein 70 family. | Heat shock regulator. | 0.924 |
