| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| BFO_0839 | BFO_0841 | BFO_0839 | BFO_0841 | Peptidase, U32 family; Identified by match to protein family HMM PF01136. | Competence/damage-inducible protein CinA N-terminal domain protein; Identified by match to protein family HMM PF00994; match to protein family HMM PF02464; match to protein family HMM TIGR00177; match to protein family HMM TIGR00199; match to protein family HMM TIGR00200; Belongs to the CinA family. | 0.637 |
| BFO_0839 | metA | BFO_0839 | BFO_0840 | Peptidase, U32 family; Identified by match to protein family HMM PF01136. | Homoserine O-succinyltransferase; Transfers an acetyl group from acetyl-CoA to L-homoserine, forming acetyl-L-homoserine; Belongs to the MetA family. | 0.821 |
| BFO_0841 | BFO_0839 | BFO_0841 | BFO_0839 | Competence/damage-inducible protein CinA N-terminal domain protein; Identified by match to protein family HMM PF00994; match to protein family HMM PF02464; match to protein family HMM TIGR00177; match to protein family HMM TIGR00199; match to protein family HMM TIGR00200; Belongs to the CinA family. | Peptidase, U32 family; Identified by match to protein family HMM PF01136. | 0.637 |
| BFO_0841 | metA | BFO_0841 | BFO_0840 | Competence/damage-inducible protein CinA N-terminal domain protein; Identified by match to protein family HMM PF00994; match to protein family HMM PF02464; match to protein family HMM TIGR00177; match to protein family HMM TIGR00199; match to protein family HMM TIGR00200; Belongs to the CinA family. | Homoserine O-succinyltransferase; Transfers an acetyl group from acetyl-CoA to L-homoserine, forming acetyl-L-homoserine; Belongs to the MetA family. | 0.622 |
| BFO_0841 | metH | BFO_0841 | BFO_0838 | Competence/damage-inducible protein CinA N-terminal domain protein; Identified by match to protein family HMM PF00994; match to protein family HMM PF02464; match to protein family HMM TIGR00177; match to protein family HMM TIGR00199; match to protein family HMM TIGR00200; Belongs to the CinA family. | Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | 0.538 |
| BFO_1742 | BFO_1902 | BFO_1742 | BFO_1902 | L-serine ammonia-lyase; Identified by match to protein family HMM PF03313; match to protein family HMM TIGR00720; Belongs to the iron-sulfur dependent L-serine dehydratase family. | Putative CDP-diacylglycerol-serine O-phosphatidyltransferase; Identified by match to protein family HMM PF01066; Belongs to the CDP-alcohol phosphatidyltransferase class-I family. | 0.900 |
| BFO_1742 | BFO_3153 | BFO_1742 | BFO_3153 | L-serine ammonia-lyase; Identified by match to protein family HMM PF03313; match to protein family HMM TIGR00720; Belongs to the iron-sulfur dependent L-serine dehydratase family. | Homoserine dehydrogenase; Identified by match to protein family HMM PF00696; match to protein family HMM PF00742; match to protein family HMM PF01842; match to protein family HMM PF03447; match to protein family HMM TIGR00657. | 0.835 |
| BFO_1742 | glyA | BFO_1742 | BFO_1924 | L-serine ammonia-lyase; Identified by match to protein family HMM PF03313; match to protein family HMM TIGR00720; Belongs to the iron-sulfur dependent L-serine dehydratase family. | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.960 |
| BFO_1742 | metA | BFO_1742 | BFO_0840 | L-serine ammonia-lyase; Identified by match to protein family HMM PF03313; match to protein family HMM TIGR00720; Belongs to the iron-sulfur dependent L-serine dehydratase family. | Homoserine O-succinyltransferase; Transfers an acetyl group from acetyl-CoA to L-homoserine, forming acetyl-L-homoserine; Belongs to the MetA family. | 0.814 |
| BFO_1742 | trpB | BFO_1742 | BFO_0802 | L-serine ammonia-lyase; Identified by match to protein family HMM PF03313; match to protein family HMM TIGR00720; Belongs to the iron-sulfur dependent L-serine dehydratase family. | Pyridoxal-phosphate dependent TrpB-like enzyme; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. | 0.900 |
| BFO_1902 | BFO_1742 | BFO_1902 | BFO_1742 | Putative CDP-diacylglycerol-serine O-phosphatidyltransferase; Identified by match to protein family HMM PF01066; Belongs to the CDP-alcohol phosphatidyltransferase class-I family. | L-serine ammonia-lyase; Identified by match to protein family HMM PF03313; match to protein family HMM TIGR00720; Belongs to the iron-sulfur dependent L-serine dehydratase family. | 0.900 |
| BFO_1902 | glyA | BFO_1902 | BFO_1924 | Putative CDP-diacylglycerol-serine O-phosphatidyltransferase; Identified by match to protein family HMM PF01066; Belongs to the CDP-alcohol phosphatidyltransferase class-I family. | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.900 |
| BFO_1902 | metA | BFO_1902 | BFO_0840 | Putative CDP-diacylglycerol-serine O-phosphatidyltransferase; Identified by match to protein family HMM PF01066; Belongs to the CDP-alcohol phosphatidyltransferase class-I family. | Homoserine O-succinyltransferase; Transfers an acetyl group from acetyl-CoA to L-homoserine, forming acetyl-L-homoserine; Belongs to the MetA family. | 0.800 |
| BFO_1902 | trpB | BFO_1902 | BFO_0802 | Putative CDP-diacylglycerol-serine O-phosphatidyltransferase; Identified by match to protein family HMM PF01066; Belongs to the CDP-alcohol phosphatidyltransferase class-I family. | Pyridoxal-phosphate dependent TrpB-like enzyme; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. | 0.900 |
| BFO_2558 | BFO_3153 | BFO_2558 | BFO_3153 | Methylenetetrahydrofolate reductase (NAD(P)H); Identified by match to protein family HMM PF02219; Belongs to the methylenetetrahydrofolate reductase family. | Homoserine dehydrogenase; Identified by match to protein family HMM PF00696; match to protein family HMM PF00742; match to protein family HMM PF01842; match to protein family HMM PF03447; match to protein family HMM TIGR00657. | 0.851 |
| BFO_2558 | glyA | BFO_2558 | BFO_1924 | Methylenetetrahydrofolate reductase (NAD(P)H); Identified by match to protein family HMM PF02219; Belongs to the methylenetetrahydrofolate reductase family. | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.943 |
| BFO_2558 | metA | BFO_2558 | BFO_0840 | Methylenetetrahydrofolate reductase (NAD(P)H); Identified by match to protein family HMM PF02219; Belongs to the methylenetetrahydrofolate reductase family. | Homoserine O-succinyltransferase; Transfers an acetyl group from acetyl-CoA to L-homoserine, forming acetyl-L-homoserine; Belongs to the MetA family. | 0.863 |
| BFO_2558 | metH | BFO_2558 | BFO_0838 | Methylenetetrahydrofolate reductase (NAD(P)H); Identified by match to protein family HMM PF02219; Belongs to the methylenetetrahydrofolate reductase family. | Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | 0.998 |
| BFO_3058 | BFO_3153 | BFO_3058 | BFO_3153 | O-acetylhomoserine aminocarboxypropyltransferase/cysteine synthase; Identified by match to protein family HMM PF01053; match to protein family HMM TIGR01326. | Homoserine dehydrogenase; Identified by match to protein family HMM PF00696; match to protein family HMM PF00742; match to protein family HMM PF01842; match to protein family HMM PF03447; match to protein family HMM TIGR00657. | 0.921 |
| BFO_3058 | metA | BFO_3058 | BFO_0840 | O-acetylhomoserine aminocarboxypropyltransferase/cysteine synthase; Identified by match to protein family HMM PF01053; match to protein family HMM TIGR01326. | Homoserine O-succinyltransferase; Transfers an acetyl group from acetyl-CoA to L-homoserine, forming acetyl-L-homoserine; Belongs to the MetA family. | 0.962 |