| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| BFO_0479 | cbiD | BFO_0479 | BFO_2783 | Putative bifunctional adenosylcobalamin biosynthesis protein CobU; Identified by match to protein family HMM PF02283. | Cobalamin biosynthesis protein CbiD; Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A. | 0.725 |
| BFO_0479 | cbiE | BFO_0479 | BFO_2781 | Putative bifunctional adenosylcobalamin biosynthesis protein CobU; Identified by match to protein family HMM PF02283. | Precorrin-6y C5,15-methyltransferase (decarboxylating), CbiE subunit; Identified by match to protein family HMM TIGR02467; match to protein family HMM TIGR02469. | 0.768 |
| BFO_0479 | cobB | BFO_0479 | BFO_0026 | Putative bifunctional adenosylcobalamin biosynthesis protein CobU; Identified by match to protein family HMM PF02283. | Cobyrinic acid a,c-diamide synthase; Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of cobyrinate, using either L-glutamine or ammonia as the nitrogen source; Belongs to the CobB/CbiA family. | 0.841 |
| BFO_0479 | cobC | BFO_0479 | BFO_0901 | Putative bifunctional adenosylcobalamin biosynthesis protein CobU; Identified by match to protein family HMM PF02283. | Alpha-ribazole phosphatase; Identified by match to protein family HMM PF00300; match to protein family HMM TIGR03162. | 0.798 |
| BFO_0479 | cobD | BFO_0479 | BFO_1843 | Putative bifunctional adenosylcobalamin biosynthesis protein CobU; Identified by match to protein family HMM PF02283. | Cobalamin biosynthesis protein CobD; Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group. | 0.985 |
| BFO_0479 | cobJ | BFO_0479 | BFO_2780 | Putative bifunctional adenosylcobalamin biosynthesis protein CobU; Identified by match to protein family HMM PF02283. | precorrin-3B C(17)-methyltransferase; Identified by match to protein family HMM PF00590; match to protein family HMM PF02570; match to protein family HMM TIGR01466. | 0.815 |
| BFO_0479 | cobM | BFO_0479 | BFO_2782 | Putative bifunctional adenosylcobalamin biosynthesis protein CobU; Identified by match to protein family HMM PF02283. | Precorrin-4 C(11)-methyltransferase; Identified by match to protein family HMM PF00590; match to protein family HMM PF01890; match to protein family HMM TIGR01465; Belongs to the precorrin methyltransferase family. | 0.892 |
| BFO_0479 | cobQ | BFO_0479 | BFO_1844 | Putative bifunctional adenosylcobalamin biosynthesis protein CobU; Identified by match to protein family HMM PF02283. | Cobyric acid synthase CobQ; Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation. Belongs to the CobB/CobQ family. CobQ subfamily. | 0.971 |
| BFO_0479 | cobS | BFO_0479 | BFO_0902 | Putative bifunctional adenosylcobalamin biosynthesis protein CobU; Identified by match to protein family HMM PF02283. | Cobalamin-5-phosphate synthase; Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'- phosphate; Belongs to the CobS family. | 0.987 |
| BFO_0479 | cobT | BFO_0479 | BFO_0903 | Putative bifunctional adenosylcobalamin biosynthesis protein CobU; Identified by match to protein family HMM PF02283. | Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase; Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6-dimethylbenzimidazole (DMB). | 0.974 |
| cbiD | BFO_0479 | BFO_2783 | BFO_0479 | Cobalamin biosynthesis protein CbiD; Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A. | Putative bifunctional adenosylcobalamin biosynthesis protein CobU; Identified by match to protein family HMM PF02283. | 0.725 |
| cbiD | cbiE | BFO_2783 | BFO_2781 | Cobalamin biosynthesis protein CbiD; Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A. | Precorrin-6y C5,15-methyltransferase (decarboxylating), CbiE subunit; Identified by match to protein family HMM TIGR02467; match to protein family HMM TIGR02469. | 0.999 |
| cbiD | cobB | BFO_2783 | BFO_0026 | Cobalamin biosynthesis protein CbiD; Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A. | Cobyrinic acid a,c-diamide synthase; Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of cobyrinate, using either L-glutamine or ammonia as the nitrogen source; Belongs to the CobB/CbiA family. | 0.957 |
| cbiD | cobC | BFO_2783 | BFO_0901 | Cobalamin biosynthesis protein CbiD; Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A. | Alpha-ribazole phosphatase; Identified by match to protein family HMM PF00300; match to protein family HMM TIGR03162. | 0.699 |
| cbiD | cobD | BFO_2783 | BFO_1843 | Cobalamin biosynthesis protein CbiD; Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A. | Cobalamin biosynthesis protein CobD; Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group. | 0.939 |
| cbiD | cobJ | BFO_2783 | BFO_2780 | Cobalamin biosynthesis protein CbiD; Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A. | precorrin-3B C(17)-methyltransferase; Identified by match to protein family HMM PF00590; match to protein family HMM PF02570; match to protein family HMM TIGR01466. | 0.999 |
| cbiD | cobM | BFO_2783 | BFO_2782 | Cobalamin biosynthesis protein CbiD; Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A. | Precorrin-4 C(11)-methyltransferase; Identified by match to protein family HMM PF00590; match to protein family HMM PF01890; match to protein family HMM TIGR01465; Belongs to the precorrin methyltransferase family. | 0.999 |
| cbiD | cobQ | BFO_2783 | BFO_1844 | Cobalamin biosynthesis protein CbiD; Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A. | Cobyric acid synthase CobQ; Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation. Belongs to the CobB/CobQ family. CobQ subfamily. | 0.993 |
| cbiD | cobS | BFO_2783 | BFO_0902 | Cobalamin biosynthesis protein CbiD; Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A. | Cobalamin-5-phosphate synthase; Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'- phosphate; Belongs to the CobS family. | 0.927 |
| cbiD | cobT | BFO_2783 | BFO_0903 | Cobalamin biosynthesis protein CbiD; Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A. | Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase; Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6-dimethylbenzimidazole (DMB). | 0.774 |